Y
Yumi Nakaike
Researcher at Tokyo University of Science
Publications - 7
Citations - 134
Yumi Nakaike is an academic researcher from Tokyo University of Science. The author has contributed to research in topics: Deoxygenation & Catalysis. The author has an hindex of 4, co-authored 7 publications receiving 123 citations.
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InBr3‐Catalyzed Deoxygenation of Carboxylic Acids with a Hydrosilane: Reductive Conversion of Aliphatic or Aromatic Carboxylic Acids to Primary Alcohols or Diphenylmethanes
TL;DR: In this paper, a simple and practical procedure for the direct reduction of aliphatic carboxylic acids with a variety of functional groups to a primary alcohol using the mild reducing reagent tetramethyldisiloxane (TMDS), in the presence of a catalytic amount of InBr3 has been developed.
Journal ArticleDOI
InBr3-catalyzed reduction of ketones with a hydrosilane: deoxygenation of aromatic ketones and selective synthesis of secondary alcohols and symmetrical ethers from aliphatic ketones
TL;DR: In this paper, an InBr3-Et3SiH reducing system was developed to selectively convert aliphatic ketones to a variety of secondary alcohols in moderate to good yields.
Journal ArticleDOI
3-(3-Phenoxybenzyl)amino-β-carboline: a novel antitumor drug targeting α-tubulin.
Reiko Ikeda,Masaki Kurosawa,Takazumi Okabayashi,Ayako Takei,Masamichi Yoshiwara,Tadashi Kumakura,Norio Sakai,Osamu Funatsu,Akinori Morita,Masahiko Ikekita,Yumi Nakaike,Takeo Konakahara +11 more
TL;DR: Flow cytometry showed that 2h-treated cell was induced SubG1 cell population after G2/M cell cycle arrest, and using affinity chromatography and peptide mass fingerprinting, it was found that interacting protein with this compound was α-tubulin protein.
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Me3SiCl-promoted intramolecular cyclization of aromatic compounds tethered with N,O-acetals leading to the facile preparation of 1,4-benzodiazepine skeletons
TL;DR: The Me 3 SiCl-promoted intramolecular aminomethylation of a novel type of N, O -acetals, which were prepared via a facile three-step synthesis from N -alkyl-2-oxazolidinones that leads to the production of pharmaceutically useful 1,4-benzodiazepine skeletons with a variety of functional groups is described as discussed by the authors.
Journal ArticleDOI
InBr3-Catalyzed Deoxygenation of Carboxylic Acids with a Hydrosilane: Reductive Conversion of Aliphatic or Aromatic Carboxylic Acids to Primary Alcohols or Diphenylmethanes.
TL;DR: In this paper, a variety of carboxylic acids is converted to primary alcohols applying InBr3 as a catalyst and tetramethyldisoxane as a reducing agent.