Yun-Beom Choi

TL;DR: It is reported that NO.-mediated neurotoxicity is engendered, at least in part, by reaction with superoxide anion (O.-2), apparently leading to formation of peroxynitrite (ONOO−), and not by NO.

TL;DR: It is shown that the NMDA receptor (NMDAR)-associated ion channel was modulated not only by exogenous NO but also by endogenous NO, and endogenous S-nitrosylation can regulate ion channel activity.

TL;DR: The basis for these molecular cysteine switches is reviewed, drawing on the NMDA receptor as an exemplary protein, and a molecular model for the action of S-nitrosylation based on recently derived crystal structures is proposed.

TL;DR: Sucher et al. as mentioned in this paper showed that the pharmacological properties of recombinant NMDA receptors are not comparable to those of native NMDA receptor subunits, and they also pointed out that it is difficult to reconcile disparate effects obtained with recombinant versus native N-methyl-D-aspartate receptors.

TL;DR: Two neighboring histidine residues on NR2A represent the critical determinant (termed the "short spacer") for high-affinity, voltage-independent Zn2+ inhibition using the Xenopus oocyte expression system and site-directed mutagenesis to suggest that the mechanism of high-Affinity Zn 2+ inhibition on the NMDAR involves enhancement of proton inhibition.