Y
Yun Shen
Researcher at Shanghai Jiao Tong University
Publications - 3
Citations - 36
Yun Shen is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: RANKL & Osteolysis. The author has an hindex of 2, co-authored 3 publications receiving 27 citations.
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Journal ArticleDOI
Nano-sized Al 2 O 3 particle-induced autophagy reduces osteolysis in aseptic loosening of total hip arthroplasty by negative feedback regulation of RANKL expression in fibroblasts
De Li,Chenglong Wang,Zhuokai Li,Hui Wang,Jiye He,Junfeng Zhu,Yue-Hui Zhang,Chao Shen,Fei Xiao,Yuan Gao,Xiang Zhang,Yang Li,Peng Wang,Jianping Peng,Guiquan Cai,Bin Zuo,Yuehua Yang,Yun Shen,Weidong Song,Xiaoling Zhang,Lei Shen,Xiaodong Chen +21 more
TL;DR: Investigating the relationship between RANKL levels in patients experiencing aseptic loosening after total hip arthroplasty and hip osteoarthritis and the effects of Al2O3 particles on autophagy levels and RankL expression in synovial tissues in vivo confirmed the findings of in vitro and in vivo.
Journal ArticleDOI
The inhibition of RANKL expression in fibroblasts attenuate CoCr particles induced aseptic prosthesis loosening via the MyD88-independent TLR signaling pathway
De Li,Hui Wang,Zhuokai Li,Chenglong Wang,Fei Xiao,Yuan Gao,Xiang Zhang,Peng Wang,Jianping Peng,Guiquan Cai,Bin Zuo,Yun Shen,Jin Qi,Niandong Qian,Lianfu Deng,Weidong Song,Xiaoling Zhang,Lei Shen,Xiaodong Chen +18 more
TL;DR: It is suggested that osteoclastogenesis is promoted by the CoCr-Ps-induced expression of RANKL in fibroblasts and that MyD88 is a potential target in the treatment of wear Ps-induced osteolysis.
Journal ArticleDOI
Identification of novel biomarkers and candidate small molecule drugs in rheumatoid arthritis and osteoarthritis based on bioinformatics analysis of high-throughput data.
TL;DR: New insights into the underlying pathogenesis of RA and OA are suggested, which may improve the diagnosis and treatment of these intractable chronic diseases.