Yun Sheng Yip

TL;DR: 3D hybrid scaffold enhances cell proliferation and induces cancer cells to undergo EMT, as demonstrated by significant up-regulation of EMT associated transcriptional factors including Snail1, Zeb1, and Twist2; and mesenchymal markers whereas epithelial marker, E-Cadherin was downregulated.

TL;DR: In this article, the authors highlight the current knowledge on the implications of PPARs in the tumor microenvironment, and conclude that PPAR-based anticancer treatment potentially relies on innovative strategies to modulate PPAR activity in a cell type-specific manner.

TL;DR: In this paper, a short bioinspired octapeptide, GV8, can self-assemble under mild conditions into biodegradable supramolecular physical hydrogels with high storage modulus and good biocompatibility.

TL;DR: It is suggested that FoxA2 in skeletal muscle helps maintain homeostasis, acting as a gatekeeper to maintain key inflammation parameters at the desired level upon injury, and it is conceivable that certain myositis disorders or other forms of painful musculoskeletal diseases may benefit from approaches that increaseFoxA2 activity in skeletal Muscle.

TL;DR: In this paper , an unbiased kinase inhibitor screen revealed an Angptl4-mediated kinome signaling network involving S6K, JAK, and CDK, among others, that modulates the expression of ifi202b.