Y
Yun Yen
Researcher at City of Hope National Medical Center
Publications - 3
Citations - 2408
Yun Yen is an academic researcher from City of Hope National Medical Center. The author has contributed to research in topics: RNA interference & Gene silencing. The author has an hindex of 2, co-authored 3 publications receiving 2277 citations.
Papers
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Journal ArticleDOI
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
Mark E. Davis,Jonathan E. Zuckerman,Chung Hang Jonathan Choi,David Seligson,Anthony W. Tolcher,Christopher A. Alabi,Christopher A. Alabi,Yun Yen,Jeremy D. Heidel,Antoni Ribas +9 more
TL;DR: Evidence is provided of inducing an RNAi mechanism of action in a human from the delivered siRNA and the presence of an mRNA fragment that demonstrates that siRNA-mediated mRNA cleavage occurs specifically at the site predicted for anRNAi mechanism from a patient who received the highest dose of the nanoparticles.
Journal ArticleDOI
Systemic delivery of siRNA nanoparticles targeting RRM2 suppresses head and neck tumor growth
Mohammad Aminur Rahman,A.R.M. Ruhul Amin,Xu Wang,Jonathan E. Zuckerman,Chung Hang Jonathan Choi,Bingsen Zhou,Dongsheng Wang,Sreenivas Nannapaneni,Lydia Koenig,Zhengjia Chen,Zhuo Georgia Chen,Yun Yen,Mark E. Davis,Dong M. Shin +13 more
TL;DR: A four-dose schedule of siRNA nanoparticle delivering RRM2 siRNA targeted to HNSCC tumors significantly reduced tumor progression by suppressing cell proliferation and inducing apoptosis, and show promise for the use of RRM 2 siRNA-based therapy for HNS CC and possibly NSCLC.
Patent
Traitement du cancer
Yun Yen,Thomas Schluep,John Ryan +2 more
TL;DR: In this article, the presente invention a pour objet des methodes concernant des compositions which comprennent un inhibiteur de la CDP- topoisomerase.