Y
Yung Wai Loke
Researcher at University of Cambridge
Publications - 109
Citations - 9138
Yung Wai Loke is an academic researcher from University of Cambridge. The author has contributed to research in topics: Trophoblast & Decidua. The author has an hindex of 53, co-authored 109 publications receiving 8855 citations.
Papers
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Journal ArticleDOI
HLA-E is expressed on trophoblast and interacts with CD94/NKG2 receptors on decidual NK cells.
Ashley King,David S.J. Allan,Mark Bowen,Simon J. Powis,Sarah Joseph,Sanjay Verma,Susan E. Hiby,Andrew J. McMichael,Yung Wai Loke,Veronique M. Braud +9 more
TL;DR: It is demonstrated that trophoblast cells express HLA‐E on their cell surface in addition to the previously reported expression of HLA'S and HLA•C, and it is shown that the vast majority of decidual NK cells bind to HLAE tetrameric complexes and this binding is inhibited by mAb to CD94.
Journal ArticleDOI
Angiogenic growth factor messenger ribonucleic acids in uterine natural killer cells.
Xiao Feng Li,D. Stephen Charnock-Jones,Eko Zhang,Susan E. Hiby,Shazia Malik,Kate Day,Diane Licence,J. Mark Bowen,Lucy Gardner,Ashley King,Yung Wai Loke,Stephen K. Smith +11 more
TL;DR: It is reported that in addition to vascular endothelial growth factor A (VEGF-A), human endometrium expresses messenger ribonucleic acids (mRNAs) encoding VEGF-C, placenta growth factor (PlGF), the angiopoietin 1 and Ang2, and the receptors VEGFR-3, Tie 1, and Tie 2.
Journal ArticleDOI
Immunocytochemical characterization of the unusual large granular lymphocytes in human endometrium throughout the menstrual cycle.
TL;DR: The findings suggest that the recruitment of these large granular lymphocytes to the uterus is under hormonal control and is not a local response to the presence of invading trophoblast.
Book
Human implantation : cell biology and immunology
Yung Wai Loke,Ashley King +1 more
TL;DR: This work has shown that trophoblast expression of major histocompatibility complex class 1 antigens in the early pregnant uterus is regulated by the maternal-fetal interaction, and the clinical implications of defective implantation Index are significant.
Journal ArticleDOI
CD3- leukocytes present in the human uterus during early placentation: phenotypic and morphologic characterization of the CD56++ population.
TL;DR: It is proposed that the CD56bright+ uterine leukocytes represent a distinctive, hormonally regulated subset possibly adapted to control human placentation.