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Yutaka Agatsuma

Bio: Yutaka Agatsuma is an academic researcher from Ochanomizu University. The author has contributed to research in topic(s): Leishmaniasis & Cedrela. The author has an hindex of 2, co-authored 3 publication(s) receiving 81 citation(s).
Topics: Leishmaniasis, Cedrela, Toona, Leishmania
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Journal ArticleDOI
TL;DR: From a literature search for reports on the chemical constituents of these plants, most constituents were found to be quinone derivatives or other compounds with unsaturated carbonyl groups.
Abstract: Seventy-five Myanmar timber extracts belonging to 27 families were examined for their leishmanicidal activities. Some timber extracts had significant leishmanicidal activity, especially extracts of Millettia pendula, which exhibited the most potent activity (MLC 3.1 μg/ml, MIC 1.6 μg/ml). Other timber extracts showing potent activity included those from Cedrela serrata, Cedrela toona, Cordia fragrantissima, Calophyllum kunstleri, Dalbergia cultrate, Grevillea robusta, Haplophragma adenophyllum, Michelia champaca, and Tectona grandis. From a literature search for reports on the chemical constituents of these plants, most constituents were found to be quinone derivatives or other compounds with unsaturated carbonyl groups.

68 citations


Journal ArticleDOI
TL;DR: A methanol extract of the wood of Diospyros burmanica, collected in Burma (Myanmar), was found to exhibit significant activity against Leishmania major, leading to the isolation of three novel bisnaphthoquinone analogues, burmanin A, B, and C, together with nine known compounds.
Abstract: A methanol extract of the wood of Diospyros burmanica, collected in Burma (Myanmar), was found to exhibit significant activity against Leishmania major. Subsequent chromatographically resolved fractionation led to the isolation of three novel bisnaphthoquinone analogues, burmanin A, B, and C (1–3), together with nine known compounds (4–12). The structure of 1 was confirmed by X-ray crystallography, and those of 2 and 3 by spectroscopic techniques, including 1D and 2D NMR. The inhibitory activities of the isolates were evaluated against the promastigote forms of Leishmania major and the murine macrophage-like cell line, RAW264.7.

12 citations


Journal ArticleDOI
TL;DR: A new compound (1) and 4-(S)-methoxydalbergione (2) showed effective leishmanicidal activities and the cytotoxicity of compounds 1 and 2 was also weaker than that of the other compounds.
Abstract: Leishmaniasis is a protozoan tropical infection that is estimated to be more than 0.3 million new cases occur annually worldwide. A novel phenolic compound, cultratin A (1), was isolated as a leish...

1 citations


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Journal ArticleDOI
Nisha Singh1, Bhuwan B. Mishra1, Surabhi Bajpai1, Rakesh K. Singh1  +1 moreInstitutions (1)
TL;DR: Current drug regimens, putative drug targets, numerous natural products that have shown promising antileishmanial activity along with some key issues and strategies for future research to control leishmaniasis worldwide are described.
Abstract: The growing incidence of parasitic resistance against generic pentavalent antimonials, specifically for visceral disease in Indian subcontinent, is a serious issue in Leishmania control. Notwithstanding the two treatment alternatives, that is amphotericin B and miltefosine are being effectively used but their high cost and therapeutic complications limit their use in endemic areas. In the absence of a vaccine candidate, identification, and characterization of novel drugs and targets is a major requirement of leishmanial research. This review describes current drug regimens, putative drug targets, numerous natural products that have shown promising antileishmanial activity alongwith some key issues and strategies for future research to control leishmaniasis worldwide.

140 citations


Book
19 Jun 2006
TL;DR: This chapter discusses medicinal Plants in the Family Annonaceae, focusing on the phytochemical properties of Fissistima lanuginosum, which is a synthesis of the fruit of fissistigma manubriatum and phytochemistry.
Abstract: Introduction Medicinal Plants Classified in the Family Annonaceae General Concept Fissistima lanuginosum (Hk f et Th) Merr Fissistigma manubriatum (Hk f et Th) Phaeanthus ebracteolatus (Prels) Merr References Medicinal Plants Classified in the Family Myristicaceae General Concept Knema glaucescens Jack Knema Globularia (Lamk) Warb Myristica argentea Warb Myristica elliptica Wall Ex Hook F Thoms References Medicinal Plants Classified in the Family Lauraceae General Concept Cinnamomun sintoc Bl Beilschmiedia pahangensis Gamb Bielschmiedia tonkinensis Ridl Cryptocarya griffithiana Wight Cryptocarya tomentosa Bl Litsea umbellata (Lour) Merr References Medicinal Plants Classified in the Family Piperaceae General Concept Piper Abbreviatum Opi Piper betle L Piper officinarum DC Piper sarmentosum Roxb References Medicinal Plants Classified in the Family Aristolochiaceae General Concept Aristolochia philippinensis Warb References Medicinal Plants Classified in the Family Nympheaceae General Concept Nelumbo nucifera Gaertn Nymphea Pubescens Willd Nymphea stellata Willd References Medicinal Plants Classified in the Family Menispermaceae General Concept Arcangelica flava (L) Merr Limacia oblonga Hook f & Thoms Stephania Japonica (Thunb) Miers References Medicinal Plants Classified in the Family Polygonaceae General Concept Polygonum chinense L Polygonum Minus Huds Polygonum tomentosum Willd References Medicinal Plants Classified in the Family Myrsinaceae General Concept Aegiceras corniculatum Blco Aridisia corolata Roxb Ardisia elliptica Thunb Ardisia fuliginosa Bl Ardisia humilis Vahl Ardisia lanceolata Roxb Ardisia odontophylla Wall Ardisia oxyphylla Wall Ardisia pyramidalis (Cav) Pers Ardisia ridleyi King & Gamble Ardisia squamulosa Presl Maesa cumingii Mez Maesa denticullata Mez Maesa laxa Mez Maesa perlarius (Lour) Merr Maesa ramentacea (Roxb) ADC Maesa tetrandra A DC References Medicinal Plants Classified in the Family Ebenaceae General Concept Diospyros lanceifolia Roxb Diospyros malabarica (Desr) Kostel Diospyros multiflora Blco Diospyros pilosanthera Blco Diospyros sumatrana Miq Diospyros rufa King & Gamble Diospyros toposioides King & Gamble References Medicinal Plants Classified in the Family Bombacaceae General Concept Ceiba pentandra (L) Gaertn Neesia Altissima Bl References Medicinal Plants Classified in the Family Elaeocarpaceae General Concept Elaeocarpus floribundus Bl Elaeocarpus obtusus Bl sensu King References Medicinal Plants Classified in the Family Capparaceae General Concept Capparis micrantha DC Crateva religiosa Forts References Medicinal Plants Classified in the Family Flacourtiaceae General Concept Flacourtia jangomas (Lour) Raeusch Homalium tomentosum (Vent) Benth Hydnocarpus kurzii ssp Australis Sleumer References Medicinal Plants Classified in the Family Passifloraceae General Concept Adenia cordifolia Engl Passiflora foetida L Passiflora quadrangularis L Passiflora laurifolia L References Medicinal Plants Classified in the Family Cucurbitaceae General Concept Gymnopetalum cochinchinense (Lour) Kurz Hodgsonia macrocarpa (Bl) Cogn Trichosanthes quinquangulata A Grey Trichosanthes tricuspidata Lour Trichosanthes villosa Bl Trichosanthes wawrae Cogn References Medicinal Plants Classified in the Family Connaraceae General Concept Connarus ferrugineus Jack References Medicinal Plants Classified in the Family Anisophylleaceae General Concept Anisophyllea disticha Hook f Reference Medicinal Plants Classified in the Family Rosaceae General Concept Eriobotrya japonica (Thunb) Lindl Prunus arborea (Bl) Kalkman Rubus moluccanum L References Medicinal Plants Classified in the Family Thymeleaceae General Concept Gonystylus confusus Airy Shaw Gonystylus macrophyllus (Miq) Airy Shaw References Medicinal Plants Classified in the Family Melastomataceae General Concept Blastus cogniauxii Stapf Diplectra divaricata (Willd) O Ktze Dissochaeta annulata Hook f Dissochaeta bracteata (Jack) Bl Dissochaeta punctulata Hook f ex Triana Medinilla hasseltiI Bl Medinilla radicans (Bl) Bl Melastoma polyanthum Bl Melasatoma sanguineum Sims Memecylon dichotomum CB Clarke Neodissochaeta gracilis (Jack) Bakh f Osbeckia chinensis L Pternandra coerulescens Jack References Medicinal Plants Classified in the Family Rhizophoraceae General Concept Bruguiera sexangula (Lour) Poir Carallia brachiata (Lour) Merr Carallia suffruticosa King Ceriops tagal (Pers) CB Rob Gynotroches axillaris Bl Rhizophora apiculata Bl Rhizophora mucronata Lamk References Medicinal Plants Classified in the Family Olacaceae General Concept Ochanostachys amentacea Mast Ximenia americana L Strombosia philippinensis (Baill) Rolfe References Medicinal Plants Classified in the Family Icacinaceae General Concept Gonocaryum gracile Miq References Medicinal Plants Classified in the Family Euphorbiaceae General Concept Antidesma ghaemsembilla Gaertn Euphorbia thymifolia L Macaranga tanarius Muell-Arg References Medicinal Plants Classified in the Family Sapindaceae General Concept Dodonaea viscosa (L) Jacq Lepisanthes tetraphylla (Vahl) Radlk Nephelium juglandifolium Bl Pometia pinnata Forst References Medicinal Plants Classified in the Family Anacardiaceae General Concept Dracontomelon dao (Blanco) Merr & Rolfe Gluta rhengas L Melanochyla auriculata Hook f Pentaspadon officinalis Holmes References Medicinal Plants Classified in the Family Simaroubaceae General Concept Eurycoma apiculata Benn Quassia indica (Gaertn) Nootebom References Medicinal Plants Classified in the Family Meliaceae General Concept Aglaia odorata Lour Aphanamixis grandifolia Bl Aphanamixis rohituka (Roxb) Pierre Chisocheton penduliflorus Planch ex Hiern Dysoxylum alliaceum Bl Dysoxylum cauliflorum Hiern Sandoricum koejape (Burm f) Merr Toona sureni (Bl) Merr Trichilia connaroide (Wight & Arn) Bentvelzen Xylocarpus granatum Koenig Xylocarpus moluccensis (Lamk) Roem References Medicinal Plants Classified in the Family Rutaceae General Concept Aegle marmelos Correa Atalantia monophylla DC Atalantia roxburghiana Hook f Citrus hystrix DC Citrus mitis Blco Clausena excavata Burm f Clausena lansium (Lour) Skeells Euodia elleryana F Muell Lunasia amara Blco Micromelum minutum (Forst f) W & A Paramignya andamanica Tanaka Toddalia asiatica (L) Lamk Zanthoxylum avicennae (Lamk) DC Zanthoxylum myriacanthum Wall ex Hk f References Medicinal Plants Classified in the Family Loganiaceae General Concept Fagraea auriculata Jack Fagraea blumei GDon Fagraea obovata (non Wall) King Neuburgia corynocarpa (A Gray) Leenh References Medicinal Plants Classified in the Family Gentianaceae General Concept Nymphoides indica (Thwaites) Kuntze Swertia javanica Bl References Medicinal Plants Classified in the Family Apocynaceae General Concept Alstonia angustifolia Wall ex A Dc Alstonia macrophylla Wall ex G Don Alstonia spectabilis Alstonia spatulata Bl Carissa carandas L Epigynum maingayi Hook f Ervatamia sphaerocarpa Bl Holarrhena curtisii King & Gamble Kibatalia arborea (Bl) GDon Kopsia larutensis King & Gamble Willughbeia edulis Ridl Wrightia pubescens R Br References Medicinal Plants Classified in the Family Asclepiadaceae General Concept Hoya coriacea Bl Hoya coronaria Bl Hoya diversifolia Bl Streptocaulon cumingii (Turcz) F-Vill Telosma cordata (Burmf) Merr References Medicinal Plants Classified in the Family Solanaceae General Concept Capsicum minimum Roxb Solanum ferox var laniocarpum Solanum mammosum L Solanum nigrum L Solanum verbascifolium L References Medicinal Plants Classified in the Family Verbenaceae General Concept Callicarpa arborea Roxb Clerodendrum dDeflexum Wall Clerodendrum inerm (L) Gaertn Duranta plumieri Jacq Gmelina elliptica Sm Peronema canescens Jack Sphenodesme pentandra Jack Sphenodesme trifolia Wight Teijmanniodendron pteropodium (Miq) Bakh References Index

135 citations


Journal ArticleDOI
TL;DR: This review highlights the potential that remains untapped in natural products as drug leads for NTDs, and covers natural products from plant, marine, and microbial sources including natural-product-inspired semi-synthetic derivatives which have been evaluated against the various causative agents of N TDs.
Abstract: Endemic in 149 tropical and subtropical countries, neglected tropical diseases (NTDs) affect more than 1 billion people annually, including 875 million children in developing economies. These diseases are also responsible for over 500,000 deaths per year and are characterized by long-term disability and severe pain. The impact of the combined NTDs closely rivals that of malaria and tuberculosis. Current treatment options are associated with various limitations including widespread drug resistance, severe adverse effects, lengthy treatment duration, unfavorable toxicity profiles, and complicated drug administration procedures. Natural products have been a valuable source of drug regimens that form the cornerstone of modern pharmaceutical care. In this review, we highlight the potential that remains untapped in natural products as drug leads for NTDs. We cover natural products from plant, marine, and microbial sources including natural-product-inspired semi-synthetic derivatives which have been evaluated against the various causative agents of NTDs. Our coverage is limited to four major NTDs which include human African trypanosomiasis (sleeping sickness), leishmaniasis, schistosomiasis and lymphatic filariasis.

107 citations


Journal ArticleDOI
TL;DR: The plant species screened in this research was recorded by several indigenous medicinal practitioners as antiparasitic, anticancer and/or related activities to the human major organ system.
Abstract: Aim of study This study screened for anthelmintic and/or antitumour bioactive compounds from Thai indigenous plants and evaluated effectiveness against three different worm species and two cancer cell lines. Materials and methods Methylene chloride and methanol extracts of 32 plant species were screened for in vitro anthelmintic activity against three species of worms, the nematode Caenorhabditis elegans, the digeneans Paramphistomum epiclitum and Schistosoma mansoni (cercariae). Cytotoxicity of the extracts was evaluated against two cancer cell lines: human amelanotic melanoma (C32) and human cervical carcinoma (HeLa) by the SRB assay. Anthelmintic and anticancer activities were evaluated by the inhibiting concentration at 50% death (IC50) and the selectivity index (SI) relative to human fibroblasts. Results and conclusions None of the extracts were active against Paramphistomum epiclitum. Plumbagin, a pure compound from Plumbago indica, had the strongest activity against Caenorhabditis elegans. The methylene chloride extract of Piper chaba fruits had the strongest activity against schistosome cercariae. Strong cytotoxicity was shown by the methylene chloride extract of Michelia champaca bark and the methanol extract of Curcuma longa rhizome against C32 and HeLa, respectively. These extracts had higher SI (>100) than positive controls in relation to either the worms or the cell lines. The methanol extract of Bouea burmanica had a slightly lower activity towards C32 cells than did Michelia champaca but had a much higher SI (>27,000). Ethnopharmacological relevance The plant species screened in this research was recorded by several indigenous medicinal practitioners as antiparasitic, anticancer and/or related activities to the human major organ system.

91 citations


Journal ArticleDOI
TL;DR: Results showed that (−) mammea A/BB is a potent growth inhibitor of L. amazonensis and caused important changes in the parasite’s ultrastructure, which provided new perspectives on the development of novel drugs with leishmanicidal activity obtained from natural products.
Abstract: Infections by protozoans of the genus Leishmania are a major worldwide health problem, with high endemicity in developing countries. The drugs of choice for the treatment of leishmaniasis are the pentavalent antimonials, which show renal and cardiac toxicity. As part of a search for new drugs against leishmaniasis, we evaluated the in vitro leishmanicidal activity of the (−) mammea A/BB. The compound (−) mammea A/BB is a coumarin-type mammea purified from a dichloromethane crude extract of leaves of Calophyllum brasiliense Cambess (Clusiaceae). The isolated compound was characterized using spectral analyses by UV, infrared, nuclear magnetic resonance of 1H, 13C, distortionless enhancement by polarization transfer, correlation spectroscopy, heteronuclear multiple bond correlation, and heteronuclear multiple quantum coherence. The compound (−) mammea A/BB showed significant activity against promastigote and amastigote forms of L. amazonensis, with IC50 (50% inhibition concentration of cell growth) at a concentration of 3.0 and 0.88 μg/ml and IC90 (90% inhibition concentration of cell growth) of 5.0 and 2.3 μg/ml, respectively. The coumarin (−) mammea A/BB showed no cytotoxicity against J774G8 macrophages in culture, when it was tested at high concentrations that inhibited promastigote forms. Electron microscopy studies revealed considerable ultrastructural changes when promastigote forms of L. amazonensis were treated with 3.0 μg/ml of the coumarin (−) mammea A/BB for 72 h. We observed significant changes such as mitochondrial swelling with concentric membranes in the mitochondrial matrix and intense exocytic activity in the region of the flagellar pocket. Other alterations included the appearance of binucleate cells and multiple cytoplasmic vacuolization. These results showed that (−) mammea A/BB is a potent growth inhibitor of L. amazonensis and caused important changes in the parasite’s ultrastructure. This study provided new perspectives on the development of novel drugs with leishmanicidal activity obtained from natural products.

85 citations


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Author's H-index: 2

No. of papers from the Author in previous years
YearPapers
20211
20121
20041