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Yuting Guan
Researcher at University of Pennsylvania
Publications - 27
Citations - 1530
Yuting Guan is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Gene. The author has an hindex of 13, co-authored 19 publications receiving 1164 citations. Previous affiliations of Yuting Guan include East China Normal University.
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Journal ArticleDOI
Heritable gene targeting in the mouse and rat using a CRISPR-Cas system
Dali Li,Zhongwei Qiu,Yanjiao Shao,Yuting Chen,Yuting Guan,Meizhen Liu,Yongmei Li,Na Gao,Liren Wang,Xiaoling Lu,Yongxiang Zhao,Mingyao Liu,Mingyao Liu +12 more
TL;DR: A CRISPR-Cas system is used to induce genomic DNA fragment deletion in mice by coinjecting two single-guide RNAs (sgRNAs) targeting the Uhrf2 locus with Cas9 mRNA by means of a single microinjection.
Journal ArticleDOI
CRISPR/Cas-mediated genome editing in the rat via direct injection of one-cell embryos
Yanjiao Shao,Yuting Guan,Liren Wang,Zhongwei Qiu,Meizhen Liu,Yuting Chen,Lijuan Wu,Yongmei Li,Xueyun Ma,Mingyao Liu,Mingyao Liu,Dali Li +11 more
TL;DR: This protocol provides guidelines for the selection of genomic targets, synthesis of guide RNAs, design and construction of homologous recombination template vectors, embryo microinjection, and detection of mutations and insertions in founders or their progeny.
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CRISPR/Cas9‐mediated somatic correction of a novel coagulator factor IX gene mutation ameliorates hemophilia in mouse
Yuting Guan,Yanlin Ma,Yanlin Ma,Qi Li,Zhenliang Sun,Lie Ma,Lijuan Wu,Liren Wang,Li Zeng,Yanjiao Shao,Yuting Chen,Ning Ma,Wenqing Lu,Kewen Hu,Honghui Han,Yanhong Yu,Yuanhua Huang,Mingyao Liu,Mingyao Liu,Dali Li +19 more
TL;DR: The studies suggest that CRISPR/Cas‐mediated in situ genome editing could be a feasible therapeutic strategy for human hereditary diseases, although an efficient and clinically relevant delivery system is required for further clinical studies.
Journal ArticleDOI
Large genomic fragment deletion and functional gene cassette knock-in via Cas9 protein mediated genome editing in one-cell rodent embryos
Liren Wang,Yanjiao Shao,Yuting Guan,Liang Li,Lijuan Wu,Fangrui Chen,Meizhen Liu,Huaqing Chen,Yanlin Ma,Xueyun Ma,Mingyao Liu,Mingyao Liu,Dali Li +12 more
TL;DR: Through the injection of Cas9 protein instead of mRNA into embryos, the CRISPR-Cas RNA-guided system is used for novel genetically modified mouse and rat models and fewer off-target effects of Cas 9 are observed and point mutation knock-in efficiency is increased.
Journal ArticleDOI
Kidney cytosine methylation changes improve renal function decline estimation in patients with diabetic kidney disease.
Caroline Gluck,Caroline Gluck,Chengxiang Qiu,Sang Youb Han,Matthew Palmer,Jihwan Park,Yi-An Ko,Yuting Guan,Xin Sheng,Robert L. Hanson,Jing Huang,Yong Chen,Ae Seo Deok Park,María Concepción Izquierdo,Ioannis Mantzaris,Amit Verma,James Pullman,Hongzhe Li,Katalin Susztak +18 more
TL;DR: This work shows that kidney methylation differences can be detected in patients with diabetic kidney disease and improve kidney function decline models indicating that they are potentially functionally important.