Yuval B. Simons

TL;DR: This work solves the model for the phenotypic distribution and allelic dynamics at steady state and derive robust, closed-form solutions for summary statistics of the genetic architecture of a focal trait that arises under stabilizing selection in a multidimensional trait space.

TL;DR: In this paper, the authors use population genetic models to show that recent human demography has probably had little impact on the average burden of deleterious mutations, and they further show that rare alleles are unlikely to contribute a large fraction of the heritable variation, and therefore the impact of recent growth is likely to be modest.

TL;DR: It is shown that for many diseases, rare alleles are unlikely to contribute a large fraction of the heritable variation, and therefore the impact of recent growth is likely to be modest, however, for those diseases that have a direct impact on fitness, strongly deleterious rare mutations probably do have an important role, and recent growth will have increased their impact.

TL;DR: The results suggest that the distribution of genetic variance among the loci discovered in GWAS take a simple form that depends on one evolutionary parameter, and provide a simple interpretation for missing heritability and why it varies among traits.

TL;DR: It is argued that when statistics more directly related to load are used, the results of different studies and data sets consistently reveal little or no difference in the load of non-synonymous mutations among human populations.