Yuzuru Tanaka

Bio: Yuzuru Tanaka is an academic researcher from Hokkaido University. The author has contributed to research in topics: Web page & Web application. The author has an hindex of 22, co-authored 149 publications receiving 3302 citations. Previous affiliations of Yuzuru Tanaka include Lion Corporation & University of Alberta.

The functional significance of microRNA-145 in prostate cancer.

Abstract: MicroRNAs (miRNAs) are small noncoding RNAs that have important roles in numerous cellular processes. Recent studies have shown aberrant expression of miRNAs in prostate cancer tissues and cell lines. On the basis of miRNA microarray data, we found that miR-145 is significantly downregulated in prostate cancer. We investigated the expression and functional significance of miR-145 in prostate cancer. The expression of miR-145 was low in all the prostate cell lines tested (PC3, LNCaP and DU145) compared with the normal cell line, PWR-1E, and in cancerous regions of human prostate tissue when compared with the matched adjacent normal. Overexpression of miR-145 in PC3-transfected cells resulted in increased apoptosis and an increase in cells in the G2/M phase, as detected by flow cytometry. Investigation of the mechanisms of inactivation of miR-145 through epigenetic pathways revealed significant DNA methylation of the miR-145 promoter region in prostate cancer cell lines. Microarray analyses of miR-145-overexpressing PC3 cells showed upregulation of the pro-apoptotic gene TNFSF10, which was confirmed by real-time PCR and western analysis. One of the genes significantly upregulated by miR-145 overexpression is the proapoptotic gene TNFSF10. Therefore, modulation of miR-145 may be an important therapeutic approach for the management of prostate cancer.

In vitro and in vivo evaluation of ellagic acid on melanogenesis inhibition.

Abstract: The efficacy of ellagic acid (EA), one of the naturally occurring polyphenols, in inhibiting melanogenesis was examined in vitro and in vivo. When mushroom-derived tyrosinase, a metaloprotein containing copper, was incubated with EA, enzymatic activity tended to decrease with decreasing copper concentration. Enzyme activity partially recovered when copper was added to the inactivated enzyme. Tyrosinase activity in the B16 melanoma cells was observed to recover in a dose-dependent manner when copper ions were added to the medium containing EA. Based on these results, EA is thought to react specifically with the copper located at the active centre of the tyrosinase molecule. Furthermore, when EA was applied for 6 weeks to brownish guinea-pigs, which have melanocytes in their skin, at the same time as irradiating for 2 weeks with ultra-violet light, skin pigmentation was clearly suppressed and the skin to which EA had been applied showed features similar to that of non-irradiated skin. These areas were irradiated again when the application of EA had been completed, and skin pigmentation occurred at the former site of EA application. In similar studies with hydroquinone, re-pigmentation did not occur on the sites at which hydroquinone (1%) had been applied. Based on the results reported here, EA is thought to suppress melanogenesis by reacting with activated melanocytes and without injuring cells.

Clip, connect, clone: combining application elements to build custom interfaces for information access

Abstract: Many applications provide a form-like interface for requesting information: the user fills in some fields, submits the form, and the application presents corresponding results. Such a procedure becomes burdensome if (1) the user must submit many different requests, for example in pursuing a trial-and-error search, (2) results from one application are to be used as inputs for another, requiring the user to transfer them by hand, or (3) the user wants to compare results, but only the results from one request can be seen at a time. We describe how users can reduce this burden by creating custom interfaces using three mechanisms: clipping of input and result elements from existing applications to form cells on a spreadsheet; connecting these cells using formulas, thus enabling result transfer between applications; and cloning cells so that multiple requests can be handled side by side. We demonstrate a prototype of these mechanisms, initially specialised for handling Web applications, and show how it lets users build new interfaces to suit their individual needs.

Query by image and video content: the QBIC system

Abstract: Research on ways to extend and improve query methods for image databases is widespread. We have developed the QBIC (Query by Image Content) system to explore content-based retrieval methods. QBIC allows queries on large image and video databases based on example images, user-constructed sketches and drawings, selected color and texture patterns, camera and object motion, and other graphical information. Two key properties of QBIC are (1) its use of image and video content-computable properties of color, texture, shape and motion of images, videos and their objects-in the queries, and (2) its graphical query language, in which queries are posed by drawing, selecting and other graphical means. This article describes the QBIC system and demonstrates its query capabilities. QBIC technology is part of several IBM products. >

Near-optimal hashing algorithms for approximate nearest neighbor in high dimensions

Abstract: In this article, we give an overview of efficient algorithms for the approximate and exact nearest neighbor problem. The goal is to preprocess a dataset of objects (e.g., images) so that later, given a new query object, one can quickly return the dataset object that is most similar to the query. The problem is of significant interest in a wide variety of areas.

GIS-based land-use suitability analysis: a critical overview

Abstract: There are three main objectives of this monograph: (i) to provide an introduction to geographical information technology along with an historical perspective on the evolving role of Geographic Information Systems (GIS) in planning, (ii) to overview relevant methods and techniques for GIS-based land-use suitability mapping and modeling, and (iii) to identify the trends, challenges and prospects of GIS-based land-use suitability analysis. The monograph focuses on two perspectives of GIS-based land-use suitability analysis: the techno-positivist perspective and the socio-political, public participation perspectives. It is organized into six chapters. After an introductory setting chapter, which defines the scope of land-use suitability analysis, an overview of relevant GIS technology is provided in Chapter 2 . Chapter 3 offers an historical account of the development of GIS. It also discusses the development of GIS in the context of evolving perspectives of planning. Chapter 4 gives an overview of the methods for GIS-based land-use suitability modeling. The overview provides a background against which selected case studies are discussed in Chapter 5 . The concluding chapter summarized the main points of the monographs and discusses problems and prospects for GIS-based land-use suitability analysis.