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Yvette I. Sheline
Researcher at University of Pennsylvania
Publications - 157
Citations - 25788
Yvette I. Sheline is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Major depressive disorder & Depression (differential diagnoses). The author has an hindex of 60, co-authored 141 publications receiving 23038 citations. Previous affiliations of Yvette I. Sheline include Washington University in St. Louis.
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Journal ArticleDOI
Molecular, Structural, and Functional Characterization of Alzheimer's Disease: Evidence for a Relationship between Default Activity, Amyloid, and Memory
Randy L. Buckner,Abraham Z. Snyder,Benjamin J. Shannon,Gina N. LaRossa,Rimmon Sachs,Anthony F. Fotenos,Yvette I. Sheline,William E. Klunk,Chester A. Mathis,John C. Morris,Mark A. Mintun +10 more
TL;DR: One possibility is that lifetime cerebral metabolism associated with regionally specific default activity predisposes cortical regions to AD-related changes, including amyloid deposition, metabolic disruption, and atrophy, which may be part of a network with the medial temporal lobe whose disruption contributes to memory impairment.
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Hippocampal atrophy in recurrent major depression
Yvette I. Sheline,Po W. Wang,Po W. Wang,Mokhtar H. Gado,John G. Csernansky,Michael W. Vannier +5 more
TL;DR: The results suggest that depression is associated with hippocampal atrophy, perhaps due to a progressive process mediated by glucocorticoid neurotoxicity.
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Depression Duration But Not Age Predicts Hippocampal Volume Loss in Medically Healthy Women with Recurrent Major Depression
TL;DR: There was no significant correlation between hippocampal volume and age in either post-depressive or control subjects, whereas there was a significant correlation with total lifetime duration of depression, which suggests that repeated stress during recurrent depressive episodes may result in cumulative hippocampal injury as reflected in volume loss.
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The default mode network and self-referential processes in depression
Yvette I. Sheline,M Deanna,Joseph L. Price,Melissa M. Rundle,S. Neil Vaishnavi,Abraham Z. Snyder,Mark A. Mintun,Suzhi Wang,Rebecca S. Coalson,Marcus E. Raichle +9 more
TL;DR: Depression is characterized by both stimulus-induced heightened activity and a failure to normally down-regulate activity broadly within the DMN, and these findings provide a brain network framework within which to consider the pathophysiology of depression.
Journal ArticleDOI
Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study
Yvette I. Sheline,M Deanna,Julie M. Donnelly,John M. Ollinger,Abraham Z. Snyder,Mark A. Mintun +5 more
TL;DR: Depressed patients have left amygdala hyperarousal, even when processing stimuli outside conscious awareness, and increased amygdala activation normalizes with antidepressant treatment.