Author
Zafer Asım Kaplancıklı
Other affiliations: RMIT University
Bio: Zafer Asım Kaplancıklı is an academic researcher from Anadolu University. The author has contributed to research in topics: Chemistry & Thiazole. The author has an hindex of 29, co-authored 189 publications receiving 3232 citations. Previous affiliations of Zafer Asım Kaplancıklı include RMIT University.
Topics: Chemistry, Thiazole, Medicine, Antimicrobial, Docking (molecular)
Papers published on a yearly basis
Papers
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TL;DR: New thiazole derivatives of triazoles were synthesized and evaluated for antifungal and antibacterial activity and showed that some of the compounds have very strong antIfungal activity.
206 citations
TL;DR: The synthesis of some triazoles and triazolothiadiazines starting from (5,6,7,8-tetrahydronaphthalen-2-yl)oxyacetic acid is described and some of the newly synthesized compounds were tested for analgesic activity and compounds 5b, 5c, and 5d exhibited promising analgesics activity.
Abstract: The synthesis of some triazoles and triazolothiadiazines starting from (5,6,7,8-tetrahydronaphthalen-2-yl)oxyacetic acid is described. The chemical structure of the compounds were elucidated by analytical, IR, 1H NMR and mass spectral studies. Some of the newly synthesized compounds were tested for analgesic activity and compounds 5b, 5c, and 5d exhibited promising analgesic activity.
173 citations
TL;DR: Several 1-(4-aryl- 2-thiazolyl)-3-(2-thienyl)-5- Daryl-1-thiocarbamoyl-2-pyrazolines with phenacyl bromides in ethanol derivatives showed antimicrobial activities against Escherichia coli and Streptococcus faecalis and Candida albicans were investigated.
147 citations
TL;DR: The new 1,2,4-triazole and 1,6-aryl-7H-1,2-4-Triazolo[3,3,4]thiadiazine derivatives were synthesized as novel antimicrobial agents and their antimicrobial activities against Micrococcus luteus, Bacillus cereus, Proteus vulgaris and Candida glabrata were investigated.
140 citations
TL;DR: Some 2-[(benzazole-2-yl)thioacetylamino]thiazole derivatives (III) were synthesized by reacting 4-methyl-2-(chloroacetyamino)thiazoles derivatives (I) with benzazol- 2-thiole (II) in acetone in the presence of K(2)CO(3).
121 citations
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TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality.
Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …
33,785 citations
Journal Article•
28,685 citations
TL;DR: The Pharmacological Basis of Therapeutics, by Prof. Louis Goodman and Prof. Alfred Gilman, New York: The Macmillan Company, 1941, p.
Abstract: The Pharmacological Basis of Therapeutics A Textbook of Pharmacology, Toxicology and Therapeutics for Physicians and Medical Students. By Prof. Louis Goodman and Prof. Alfred Gilman. Pp. xiii + 1383. (New York: The Macmillan Company, 1941.) 50s. net.
2,686 citations
TL;DR: This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry and is expected to be a comprehensive, authoritative, and critical review of the chal cone template to the chemistry community.
Abstract: Privileged structures have been widely used as an effective template in medicinal chemistry for drug discovery. Chalcone is a common simple scaffold found in many naturally occurring compounds. Many chalcone derivatives have also been prepared due to their convenient synthesis. These natural products and synthetic compounds have shown numerous interesting biological activities with clinical potentials against various diseases. This review aims to highlight the recent evidence of chalcone as a privileged scaffold in medicinal chemistry. Multiple aspects of chalcone will be summarized herein, including the isolation of novel chalcone derivatives, the development of new synthetic methodologies, the evaluation of their biological properties, and the exploration of the mechanisms of action as well as target identification. This review is expected to be a comprehensive, authoritative, and critical review of the chalcone template to the chemistry community.
800 citations
TL;DR: Data indicate that aminoacridines, as a class of compounds, have a statistically significant effect to diminish, slightly, some of the cognitive symptoms of Alzheimer's Disease, and encourage the use of drugs that will reverse multiple neurotransmitter deficits.
724 citations