Z
Zamir Halpern
Researcher at Tel Aviv Sourasky Medical Center
Publications - 234
Citations - 19123
Zamir Halpern is an academic researcher from Tel Aviv Sourasky Medical Center. The author has contributed to research in topics: Population & Colonoscopy. The author has an hindex of 52, co-authored 230 publications receiving 15302 citations. Previous affiliations of Zamir Halpern include Sheba Medical Center & Tel Aviv University.
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Journal ArticleDOI
Personalized Nutrition by Prediction of Glycemic Responses
David Zeevi,Tal Korem,Niv Zmora,Niv Zmora,David Israeli,Daphna Rothschild,Adina Weinberger,Orly Ben-Yacov,Dar Lador,Tali Avnit-Sagi,Maya Lotan-Pompan,Jotham Suez,Jemal Ali Mahdi,Elad Matot,Gal Malka,Noa Kosower,Michal Rein,Gili Zilberman-Schapira,Lenka Dohnalová,Meirav Pevsner-Fischer,Rony Bikovsky,Zamir Halpern,Eran Elinav,Eran Segal +23 more
TL;DR: A machine-learning algorithm is devised that integrates blood parameters, dietary habits, anthropometrics, physical activity, and gut microbiota measured in an 800-person cohort and shows that it accurately predicts personalized postprandial glycemic response to real-life meals, and a blinded randomized controlled dietary intervention based on this algorithm resulted in significantly lower postpr andial responses and consistent alterations to gut microbiota configuration.
Journal ArticleDOI
Environment dominates over host genetics in shaping human gut microbiota
Daphna Rothschild,Omer Weissbrod,Elad Barkan,Alexander Kurilshikov,Tal Korem,David Zeevi,Paul I. Costea,Anastasia Godneva,Iris N. Kalka,Noam Bar,Smadar Shilo,Dar Lador,Arnau Vich Vila,Niv Zmora,Niv Zmora,Meirav Pevsner-Fischer,David Israeli,Noa Kosower,Gal Malka,Bat Chen Wolf,Tali Avnit-Sagi,Maya Lotan-Pompan,Adina Weinberger,Zamir Halpern,Shai Carmi,Jingyuan Fu,Cisca Wijmenga,Cisca Wijmenga,Alexandra Zhernakova,Eran Elinav,Eran Segal +30 more
TL;DR: Genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment are examined, and it is demonstrated that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition.
Journal ArticleDOI
Artificial sweeteners induce glucose intolerance by altering the gut microbiota
Jotham Suez,Tal Korem,David Zeevi,Gili Zilberman-Schapira,Christoph A. Thaiss,Ori Maza,David Israeli,Niv Zmora,Shlomit Gilad,Adina Weinberger,Yael Kuperman,Alon Harmelin,Ilana Kolodkin-Gal,Hagit Shapiro,Zamir Halpern,Eran Segal,Eran Elinav +16 more
TL;DR: It is demonstrated that consumption of commonly used NAS formulations drives the development of glucose intolerance through induction of compositional and functional alterations to the intestinal microbiota, thereby calling for a reassessment of massive NAS usage.
Journal ArticleDOI
Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features
Niv Zmora,Niv Zmora,Gili Zilberman-Schapira,Jotham Suez,Uria Mor,Mally Dori-Bachash,Stavros Bashiardes,Eran Kotler,Maya Zur,Dana Regev-Lehavi,Rotem Ben-Zeev Brik,Sara Federici,Yotam Cohen,Raquel Linevsky,Daphna Rothschild,Andreas E. Moor,Shani Ben-Moshe,Alon Harmelin,Shalev Itzkovitz,Nitsan Maharshak,Nitsan Maharshak,Oren Shibolet,Oren Shibolet,Hagit Shapiro,Meirav Pevsner-Fischer,Itai Sharon,Zamir Halpern,Zamir Halpern,Eran Segal,Eran Elinav +29 more
TL;DR: The metagenomically characterized the murine and human mucosal-associated gastrointestinal microbiome and found it to only partially correlate with stool microbiome, indicating that empiric probiotics supplementation may be limited in universally and persistently impacting the gut mucosa.
Journal ArticleDOI
Transkingdom Control of Microbiota Diurnal Oscillations Promotes Metabolic Homeostasis
Christoph A. Thaiss,David Zeevi,Maayan Levy,Gili Zilberman-Schapira,Jotham Suez,Anouk C. Tengeler,Lior Abramson,Meirav Katz,Meirav Katz,Tal Korem,Niv Zmora,Yael Kuperman,Inbal E. Biton,Shlomit Gilad,Alon Harmelin,Hagit Shapiro,Zamir Halpern,Eran Segal,Eran Elinav +18 more
TL;DR: Evidence of coordinated metaorganism diurnal rhythmicity is provided and jet-lag-induced dysbiosis in both mice and humans promotes glucose intolerance and obesity that are transferrable to germ-free mice upon fecal transplantation.