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Zengfen Pang

Bio: Zengfen Pang is an academic researcher. The author has contributed to research in topics: Medicine & Rehabilitation. The author has an hindex of 1, co-authored 1 publications receiving 410 citations.

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Journal ArticleDOI
TL;DR: The expression levels of seven diabetes-relatedMiRNAs in serum were significantly elevated in n-T2D compared with pre-diabetes and/or s-NGT, and the latter two groups featured similar expression patterns of these miRNAs, suggesting that during the pathogenesis of T2D, the peripheral diabetes- related miRNas have not changed significantly from s- NGT at pre- diabetic stage.
Abstract: To explore the clinical significance of seven diabetes-related serum microRNAs (miR-9, miR-29a, miR-30d, miR34a, miR-124a, miR146a and miR375) during the pathogenesis of type 2 diabetes (T2D), 56 subjects were recruited to this study: 18 cases of newly diagnosed T2D (n-T2D) patients, 19 cases of pre-diabetes individuals (impaired glucose tolerance [IGT] and/or impaired fasting glucose [IFG]) and 19 cases of T2D-susceptible individuals with normal glucose tolerance (s-NGT). Serum miRNAs were determined by real-time RT-PCR. Expression levels of single miRNAs and the expression signatures of miRNAs as a panel were analysed among the three groups. In n-T2D, all 7 miRNAs were significantly up-regulated compared with s-NGT and five were significantly up-regulated compared with pre-diabetes, while miRNA expression was not significantly different between s-NGT and pre-diabetes. By Canonical discriminant analysis, 70.6% of n-T2D subjects (12/17) were recognized by canonical discriminant function, while s-NGT and pre-diabetes subjects could not be discriminated from each other. Similar results were found in Hierarchical Clustering analysis based on the expression levels of all seven miRNAs. In different statistical analysis, miR-34a always showed the most significant differences. We conclude that the expression levels of seven diabetes-related miRNAs in serum were significantly elevated in n-T2D compared with pre-diabetes and/or s-NGT, and the latter two groups featured similar expression patterns of these miRNAs, suggesting that during the pathogenesis of T2D, the peripheral diabetes-related miRNAs have not changed significantly from s-NGT at pre-diabetic stage.

459 citations

Journal ArticleDOI
TL;DR: Hospital-community-family nutrition management combined with early exercise nursing can improve the postoperative nutrition status of patients undergoing gastric cancer surgery and advance the time of postoperative exhaust and defecation.
Abstract: Objective The study aimed to analyze the effect of hospital-community-family (HCH) nutrition management combined with early exercise nursing on nutrition status and postoperative rehabilitation of patients after gastric cancer surgery. Methods A total of 80 patients with gastric cancer admitted from January 2019 to June 2021 were selected and divided by the odd-even grouping method into two groups, i.e., 40 cases in the control group adopting routine nursing combined with early exercise nursing and 40 cases in the study group adopting HCH nutrition management; the nutrition status and postoperative rehabilitation of the two groups were compared. Results The times of feeding, bowel sound, anal exhaust, and defecation in the study group after surgery were shorter than those in the control group, with a difference of statistical significance (P < 0.05). 3 months after discharge, the scores of Patient-Generated Subjective Global Assessment (PG-SAG) in the study group were lower than those in the control group, while the body mass index (BMI), prealbumin, albumin, hemoglobin, and the score of the Gastrointestinal Quality of Life Index (GIQLI) were higher than those of the control group (P < 0.05). Conclusion Hospital-community-family nutrition management combined with early exercise nursing can improve the postoperative nutrition status of patients undergoing gastric cancer surgery and advance the time of postoperative exhaust and defecation.

2 citations

Journal ArticleDOI
TL;DR: By comparing patient postoperative adverse reactions, satisfaction, and readmission rates, the ERAS care group was significantly better than the traditional care group, and it can be seen that a good nursing quality evaluation index system can truly and objectively reflect the level of nursing quality and promote the hospital to further improve the medical quality.
Abstract: Objective To study the index system of enhanced recovery after surgery (ERAS) nursing evaluation, as a basis for the quality evaluation of hepatobiliary care, continue to improve the quality of hepatobiliary care. Methods The 300 cases of hepatobiliary surgical diseases treated in our hospital from January 2019 to December 2020 were randomly selected as the subjects of this study. Through clinical trials, two groups of subjects were used, one for the ERAS care group and the traditional care group. Through the questionnaire survey and access to the relevant research data, statistical data analysis was performed using the SPSS 22.0 software. Metrics were analyzed as descriptive by mean, standard deviation, and coefficient of variation. The Visual Analogue Score (VAS) Hepatobiliary Surgery Nursing Service evaluation form, service evaluation form, postoperative incidence of adverse reaction rate, patient satisfaction, and readmission rate questionnaire were established from the aspects of structural quality and process quality. An index system of hepatobiliary surgery nursing quality evaluation based on the ERAS concept was constructed. Results This study compared the degree of VAS pain through postoperative care. The ERAS care group scored significantly lower than in the traditional care group. Nursing patients based on ERAS are very satisfied with the quality of care services. By comparing patient postoperative adverse reactions, satisfaction, and readmission rates, the ERAS care group was significantly better than the traditional care group. It can be seen that a good nursing quality evaluation index system can truly and objectively reflect the level of nursing quality and promote the hospital to further improve the medical quality. Conclusion The research on the construction of nursing quality evaluation index system of hepatobiliary surgery based on ERAS concept provides a more scientific evaluation standard for nursing quality evaluation of hepatobiliary surgery ERAS, creates conditions for digital and intelligent management of nursing quality, and provides a basis for formulating a unified nursing quality evaluation index system of hepatobiliary surgery. It is of practical significance to improve the nursing quality of ERAS in hepatobiliary surgery.

1 citations

Journal ArticleDOI
TL;DR: Patients with open lower limbs who received RNI can help patients reduce postoperative anxiety and stress, promote postoperative rehabilitation and improve their quality of life.
Abstract: Objective The study aims to analyze the efficacy of rehabilitation nursing interventions on patients with open lower limb fractures. Methods From June 2020, patients who received RNI (observation group) were included and compared with patients who received routine nursing interventions (control group). The efficacy of different nursing modes was compared with several indicators. Results One hundred patients were included in this study, 50 in each group. The baseline characteristics were not significantly different between the groups. Regarding the emotional scores, the Self-Rating Anxiety Scale (SAS) score (26.98 vs 43.47), and Distress Management Screening Measure (DMSM) score (8.01 vs 12.85) in the observation group were significantly lower than those in the control group, both P < 0.05. Regarding the postoperative related indexes, the postoperative pain score (10.13 vs 15.53), fracture healing time (6.32 vs 10.86 weeks), and postoperative complications rate (0 vs 12%) in the observation group were all significantly lower than those in the control group, all P < 0.05. Regarding the quality of life scores, the WHOQOL-100 score (94.12 vs 83.13) and PSQI score (6.43 vs 10.36) were both significantly better in the observation group, with both P < 0.05. Conclusion Patients with open lower limbs who received RNI can help patients reduce postoperative anxiety and stress, promote postoperative rehabilitation and improve their quality of life.

1 citations

Journal ArticleDOI
TL;DR: In this article , the authors investigated the influence of long-term night shift nurses on the composition of the intestinal microbial community by double-end sequencing based on bacterial 16S rDNA V3+V4 and fungal 18S r DNA V3−V4.
Abstract: Objective To investigate the influence of long-term night shift nurses on the composition. Methods The feces of 30 night shift nurses (test group) and 30 day shift nurses (control group) over 1 year were collected, and double-end sequencing based on bacterial 16S rDNA V3 + V4 and fungal 18S rDNA V3 + V4 was used to determine the differences by OTU clustering, diversity, flora abundance, and differential analysis. The results of 60 samples were sequenced for a total of 3, 052. There were 418 high-quality sequences, each sample produced an average of 50, 874 high-quality sequences. The OTU cluster analysis revealed that the number of OTUs was 365. The number of day-shift shift OTUs was 362. There was no significant difference (p < 0.05). There was no significant statistical difference in the Chao, Ace, Shan'non, and Simpson index between the 2 groups (P > 0.05). Differential analysis of gut microflora between 2 groups showed that at the phylum level, the relative abundance of firmicutes in long-term night shift nurses was higher than in day shift nurses. However, the relative abundance of bacteroidetes was lower than that of white shift nurses (all p < 0.05). At the genus level, long-term night shift nurses' Bacteroides, Faecacterium, and Bifidobacterial were lower than that of white shift nurses (p < 0.05). However, the relative abundance of Prevotella and Megomonas was higher than that of white shift nurses (all p < 0.05). Conclusion There are differences between night shift nurses, which lead to a decrease in intestinal probiotic flora and increased conditional pathogenic flora. Nursing managers should improve the intestinal flora change of night shift nurses through reasonable scheduling and dietary regulation.

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Daniel D Murray1, Kazuo Suzuki1, Matthew Law1, Jonel Trebicka2  +1486 moreInstitutions (9)
14 Oct 2015-PLOS ONE
TL;DR: No associations with mortality were found with any circulating miRNAs studied and these results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection.
Abstract: Introduction The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to the non-HIV-1 infected population and this appears to be related to end-organ diseases collectively referred to as Serious Non-AIDS Events (SNAEs). Circulating miRNAs are reported as promising biomarkers for a number of human disease conditions including those that constitute SNAEs. Our study sought to investigate the potential of selected miRNAs in predicting mortality in HIV-1 infected ART treated individuals. Materials and Methods A set of miRNAs was chosen based on published associations with human disease conditions that constitute SNAEs. This case: control study compared 126 cases (individuals who died whilst on therapy), and 247 matched controls (individuals who remained alive). Cases and controls were ART treated participants of two pivotal HIV-1 trials. The relative abundance of each miRNA in serum was measured, by RTqPCR. Associations with mortality (all-cause, cardiovascular and malignancy) were assessed by logistic regression analysis. Correlations between miRNAs and CD4+ T cell count, hs-CRP, IL-6 and D-dimer were also assessed. Results None of the selected miRNAs was associated with all-cause, cardiovascular or malignancy mortality. The levels of three miRNAs (miRs -21, -122 and -200a) correlated with IL-6 while miR-21 also correlated with D-dimer. Additionally, the abundance of miRs -31, -150 and -223, correlated with baseline CD4+ T cell count while the same three miRNAs plus miR-145 correlated with nadir CD4+ T cell count. Discussion No associations with mortality were found with any circulating miRNA studied. These results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection.

3,094 citations

Journal ArticleDOI
TL;DR: Dysregulation of miRNAs may contribute to metabolic abnormalities, suggesting that mi RNAs may potentially serve as therapeutic targets for ameliorating cardiometabolic disorders.
Abstract: MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example, miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in concert with their host genes, the sterol-regulatory element-binding protein (SREBP) transcription factors. Other metabolic miRNAs, such as miR-103 and miR-107, regulate insulin and glucose homeostasis, whereas miRNAs such as miR-34a are emerging as key regulators of hepatic lipid homeostasis. The discovery of circulating miRNAs has highlighted their potential as both endocrine signalling molecules and disease markers. Dysregulation of miRNAs may contribute to metabolic abnormalities, suggesting that miRNAs may potentially serve as therapeutic targets for ameliorating cardiometabolic disorders.

998 citations

Journal ArticleDOI
TL;DR: The results suggest that circulating miRNAs may serve as biomarkers to differentiate between hepatocyte injury and inflammation and the exosome versus protein association of mi RNAs may provide further specificity to mechanisms of liver pathology.

569 citations

Journal ArticleDOI
TL;DR: In this paper, microRNAs (miRNAs) are used as biomarkers for early detection of the disease and identification of individuals at risk of developing complications, which would greatly improve the care of these patients.
Abstract: Diabetes mellitus is characterized by insulin secretion from pancreatic β cells that is insufficient to maintain blood glucose homeostasis. Autoimmune destruction of β cells results in type 1 diabetes mellitus, whereas conditions that reduce insulin sensitivity and negatively affect β-cell activities result in type 2 diabetes mellitus. Without proper management, patients with diabetes mellitus develop serious complications that reduce their quality of life and life expectancy. Biomarkers for early detection of the disease and identification of individuals at risk of developing complications would greatly improve the care of these patients. Small non-coding RNAs called microRNAs (miRNAs) control gene expression and participate in many physiopathological processes. Hundreds of miRNAs are actively or passively released in the circulation and can be used to evaluate health status and disease progression. Both type 1 diabetes mellitus and type 2 diabetes mellitus are associated with distinct modifications in the profile of miRNAs in the blood, which are sometimes detectable several years before the disease manifests. Moreover, circulating levels of certain miRNAs seem to be predictive of long-term complications. Technical and scientific obstacles still exist that need to be overcome, but circulating miRNAs might soon become part of the diagnostic arsenal to identify individuals at risk of developing diabetes mellitus and its devastating complications.

476 citations

Journal ArticleDOI
TL;DR: The findings that led to these conclusions are reviewed and how this sets the stage for new lines of investigation in which extracellular miRNAs are recognized as important mediators of intercellular communication and potential candidates for therapy of disease.

408 citations