Z
Zhaochen Luo
Researcher at Huazhong Agricultural University
Publications - 21
Citations - 274
Zhaochen Luo is an academic researcher from Huazhong Agricultural University. The author has contributed to research in topics: Rabies virus & Rabies. The author has an hindex of 8, co-authored 19 publications receiving 170 citations.
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Journal ArticleDOI
Critical Role of K1685 and K1829 in the Large Protein of Rabies Virus in Viral Pathogenicity and Immune Evasion.
Dayong Tian,Zhaochen Luo,Ming Zhou,Mingming Li,Lan Yu,Chong Wang,Jiaolong Yuan,Fang Li,Bin Tian,Baokun Sui,Huanchun Chen,Zhen F. Fu,Ling Zhao +12 more
TL;DR: The results suggest that K1685 and K1829 in the L protein play important roles in pathogenicity and immune evasion during RABV infection.
Journal ArticleDOI
Lab-Attenuated Rabies Virus Causes Abortive Infection and Induces Cytokine Expression in Astrocytes by Activating Mitochondrial Antiviral-Signaling Protein Signaling Pathway
Bin Tian,Ming Zhou,Yu Yang,Lan Yu,Zhaochen Luo,Dayong Tian,Wang Ke,Min Cui,Huanchun Chen,Zhen F. Fu,Zhen F. Fu,Ling Zhao +11 more
TL;DR: It is demonstrated that lab-attenuated RABV causes abortive infection in astrocytes, the most abundant glial cells in the CNS, and it is suggested that astroCytes play a critical role in limiting the replication of lab-hatted RABVs in the central nervous system.
Journal ArticleDOI
A novel antiviral lncRNA, EDAL, shields a T309 O -GlcNAcylation site to promote EZH2 lysosomal degradation
Baokun Sui,Dong Chen,Wei Liu,Qiong Wu,Bin Tian,Yingying Li,Jing Hou,Shiyong Liu,Juan Xie,Hao Jiang,Zhaochen Luo,Lei Lv,Fei Huang,Ruiming Li,Chengguang Zhang,Yuling Tian,Min Cui,Ming Zhou,Huanchun Chen,Zhen F. Fu,Zhen F. Fu,Yi Zhang,Ling Zhao +22 more
TL;DR: Findings show that a neuronal lncRNA can exert an effective antiviral function via blocking a specific O-GlcNAcylation that determines EZH2 lysosomal degradation, rather than the traditional interferon-dependent pathway.
Journal ArticleDOI
λ-Carrageenan P32 Is a Potent Inhibitor of Rabies Virus Infection.
Zhaochen Luo,Dayong Tian,Ming Zhou,Wenjie Xiao,Yachun Zhang,Mingming Li,Baokun Sui,Wang Wei,Guan Huashi,Huanchun Chen,Zhen F. Fu,Ling Zhao +11 more
TL;DR: The results indicate that λ-CG P32 is a promising agent that can inhibit RABV infection mainly by inhibiting viral internalization and glycoprotein-mediated cell fusion and can be used for the development of novel anti-RABV drugs.
Journal ArticleDOI
Overexpression of Interleukin-7 Extends the Humoral Immune Response Induced by Rabies Vaccination.
Yingying Li,Ming Zhou,Zhaochen Luo,Yachun Zhang,Min Cui,Huanchun Chen,Zhen F. Fu,Zhen F. Fu,Ling Zhao +8 more
TL;DR: The results suggest that the expression of IL-7 is beneficial for induction of potent and long-lasting humoral immune responses following rabies vaccination, and overexpressing IL- 7 improved the induction of long- lasting primary and secondary antibody responses post-RABV immunization.