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Zhen Li

Bio: Zhen Li is an academic researcher from Wuhan University. The author has contributed to research in topics: Medicine & Computer science. The author has an hindex of 127, co-authored 1712 publications receiving 71351 citations. Previous affiliations of Zhen Li include Tsinghua University & Hong Kong University of Science and Technology.


Papers
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Journal ArticleDOI
TL;DR: In this article, the Suzuki coupling copolymerization reaction was used to develop more "H" shape nonlinear optical polymers, which exhibited good film-forming ability, thermal stability, and large optical nonlinearities.

22 citations

Posted Content
TL;DR: This paper presents an effective video saliency detector that consists of a spatial refinement network and a spatiotemporal module and proposes a novel method for generating pixel-level pseudo-labels from sparsely annotated frames.
Abstract: Deep learning-based video salient object detection has recently achieved great success with its performance significantly outperforming any other unsupervised methods. However, existing data-driven approaches heavily rely on a large quantity of pixel-wise annotated video frames to deliver such promising results. In this paper, we address the semi-supervised video salient object detection task using pseudo-labels. Specifically, we present an effective video saliency detector that consists of a spatial refinement network and a spatiotemporal module. Based on the same refinement network and motion information in terms of optical flow, we further propose a novel method for generating pixel-level pseudo-labels from sparsely annotated frames. By utilizing the generated pseudo-labels together with a part of manual annotations, our video saliency detector learns spatial and temporal cues for both contrast inference and coherence enhancement, thus producing accurate saliency maps. Experimental results demonstrate that our proposed semi-supervised method even greatly outperforms all the state-of-the-art fully supervised methods across three public benchmarks of VOS, DAVIS, and FBMS.

22 citations

Journal ArticleDOI
TL;DR: The hexagonal WO3 hierarchical nanostructures with and without seeds were synthesized by a seed-assisted hydrothermal process in this paper, where the reduced activation energy barrier and the 6-fold symmetry intrinsically of WO 3 crystallites triggered the hexagonal shape.

22 citations

Journal ArticleDOI
TL;DR: In this paper , a Mo doping approach is adopted to enhance the HER and OER bifunctionality of NiFe-LDH, and the MoNiFeSx@FeNi3 obtained after sulfidation exhibits further improved catalytic performance and good stability.

22 citations


Cited by
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Journal ArticleDOI

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08 Dec 2001-BMJ
TL;DR: There is, I think, something ethereal about i —the square root of minus one, which seems an odd beast at that time—an intruder hovering on the edge of reality.
Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

33,785 citations

01 May 1993
TL;DR: Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems.
Abstract: Three parallel algorithms for classical molecular dynamics are presented. The first assigns each processor a fixed subset of atoms; the second assigns each a fixed subset of inter-atomic forces to compute; the third assigns each a fixed spatial region. The algorithms are suitable for molecular dynamics models which can be difficult to parallelize efficiently—those with short-range forces where the neighbors of each atom change rapidly. They can be implemented on any distributed-memory parallel machine which allows for message-passing of data between independently executing processors. The algorithms are tested on a standard Lennard-Jones benchmark problem for system sizes ranging from 500 to 100,000,000 atoms on several parallel supercomputers--the nCUBE 2, Intel iPSC/860 and Paragon, and Cray T3D. Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems. For large problems, the spatial algorithm achieves parallel efficiencies of 90% and a 1840-node Intel Paragon performs up to 165 faster than a single Cray C9O processor. Trade-offs between the three algorithms and guidelines for adapting them to more complex molecular dynamics simulations are also discussed.

29,323 citations

Journal ArticleDOI
15 Jul 2021-Nature
TL;DR: For example, AlphaFold as mentioned in this paper predicts protein structures with an accuracy competitive with experimental structures in the majority of cases using a novel deep learning architecture. But the accuracy is limited by the fact that no homologous structure is available.
Abstract: Proteins are essential to life, and understanding their structure can facilitate a mechanistic understanding of their function. Through an enormous experimental effort1–4, the structures of around 100,000 unique proteins have been determined5, but this represents a small fraction of the billions of known protein sequences6,7. Structural coverage is bottlenecked by the months to years of painstaking effort required to determine a single protein structure. Accurate computational approaches are needed to address this gap and to enable large-scale structural bioinformatics. Predicting the three-dimensional structure that a protein will adopt based solely on its amino acid sequence—the structure prediction component of the ‘protein folding problem’8—has been an important open research problem for more than 50 years9. Despite recent progress10–14, existing methods fall far short of atomic accuracy, especially when no homologous structure is available. Here we provide the first computational method that can regularly predict protein structures with atomic accuracy even in cases in which no similar structure is known. We validated an entirely redesigned version of our neural network-based model, AlphaFold, in the challenging 14th Critical Assessment of protein Structure Prediction (CASP14)15, demonstrating accuracy competitive with experimental structures in a majority of cases and greatly outperforming other methods. Underpinning the latest version of AlphaFold is a novel machine learning approach that incorporates physical and biological knowledge about protein structure, leveraging multi-sequence alignments, into the design of the deep learning algorithm. AlphaFold predicts protein structures with an accuracy competitive with experimental structures in the majority of cases using a novel deep learning architecture.

10,601 citations