Zhencheng Chen

Bio: Zhencheng Chen is an academic researcher from Guilin University of Electronic Technology. The author has contributed to research in topics: Medicine & Electrochemical gas sensor. The author has an hindex of 13, co-authored 44 publications receiving 656 citations. Previous affiliations of Zhencheng Chen include Central South University.

Hypertension Assessment via ECG and PPG Signals: An Evaluation Using MIMIC Database.

Abstract: Cardiovascular diseases (CVDs) have become the biggest threat to human health, and they are accelerated by hypertension The best way to avoid the many complications of CVDs is to manage and prevent hypertension at an early stage However, there are no symptoms at all for most types of hypertension, especially for prehypertension The awareness and control rates of hypertension are extremely low In this study, a novel hypertension management method based on arterial wave propagation theory and photoplethysmography (PPG) morphological theory was researched to explore the physiological changes in different blood pressure (BP) levels Pulse Arrival Time (PAT) and photoplethysmogram (PPG) features were extracted from electrocardiogram (ECG) and PPG signals to represent the arterial wave propagation theory and PPG morphological theory, respectively Three feature sets, one containing PAT only, one containing PPG features only, and one containing both PAT and PPG features, were used to classify the different BP categories, defined as normotension, prehypertension, and hypertension PPG features were shown to classify BP categories more accurately than PAT Furthermore, PAT and PPG combined features improved the BP classification performance The F1 scores to classify normotension versus prehypertension reached 8434%, the scores for normotension versus hypertension reached 9484%, and the scores for normotension plus prehypertension versus hypertension reached 8849% This indicates that the simultaneous collection of ECG and PPG signals could detect hypertension

A disposable paper-based microfluidic immunosensor based on reduced graphene oxide-tetraethylene pentamine/Au nanocomposite decorated carbon screen-printed electrodes

Abstract: A novel, disposable and sensitive microfluidic paper-based electrochemical immunosensor (μ-PEI) was developed by using gold nanoparticles (Au NPs) decorated reduced graphene oxide-tetraethylene pentamine (rGO-TEPA/Au nanocomposite) as electrode materials The rGO-TEPA greatly amplified the current response due to its excellent conductivity and large surface area Au NPs was decorated on the surface of rGO-TEPA to increase the biocompatibility and retained good stability for rGO-TEPA/Au nanocomposite, which was used as an effective sensor platform for anchoring the capturing antibodies (Ab 1 ) and accelerating the electron transfer to the screen-printed electrodes (SPEs) The simple and disposable paper-based microfluidic channel patterned on the rGO-TEPA/Au nanocomposite modified SPEs (SPEs/rGO-TEPA/Au) was designed for combination of immunochromatography and immunofiltration simultaneously With the combination of portable SPEs/rGO-TEPA/Au and simple paper-based microfluidic devices, horseradish peroxidase (HRP) and labeled signal antibodies (Ab 2 ) co-immobilized gold nanorods (HRP-GNRs-Ab 2 ) was explored as the tracers for square wave voltammetry (SWV) detection Using Alpha-Fetoprotein (AFP) as a model analyte, the proposed μ-PEI exhibited a satisfactory performance like simple fabrication, high stability, selectivity, wide linear range (001 ng mL −1 –1000 ng mL −1 ) with a low detection limit (0005 ng mL −1 ) Furthermore, human serum were applied to the obtained μ-PEI and determined with satisfactory results

Hydrogen Bonding in the Electronic Excited State

Abstract: Because of its fundamental importance in many branches of science, hydrogen bonding is a subject of intense contemporary research interest. The physical and chemical properties of hydrogen bonds in the ground state have been widely studied both experimentally and theoretically by chemists, physicists, and biologists. However, hydrogen bonding in the electronic excited state, which plays an important role in many photophysical processes and photochemical reactions, has scarcely been investigated.Upon electronic excitation of hydrogen-bonded systems by light, the hydrogen donor and acceptor molecules must reorganize in the electronic excited state because of the significant charge distribution difference between the different electronic states. The electronic excited-state hydrogen-bonding dynamics, which are predominantly determined by the vibrational motions of the hydrogen donor and acceptor groups, generally occur on ultrafast time scales of hundreds of femtoseconds. As a result, state-of-the-art femtos...

Lateral flow assays

Abstract: Lateral flow assays (LFAs) are the technology behind low-cost, simple, rapid and portable detection devices popular in biomedicine, agriculture, food and environmental sciences. This review presents an overview of the principle of the method and the critical components of the assay, focusing on lateral flow immunoassays. This type of assay has recently attracted considerable interest because of its potential to provide instantaneous diagnosis directly to patients. The range and interpretation of results and parameters used for evaluation of the assay will also be discussed. The main advantages and disadvantages of LFAs will be summarized and relevant future improvements to testing devices and strategies will be proposed. Finally, the major recent advances and future diagnostic applications in the LFA field will be explored.

Lateral flow assays: Principles, designs and labels

Abstract: Lateral flow assays (LFAs) have attracted interest due to their friendly user formats, short assay times, little interferences, low costs, and being easy by operated by non-specialized personnel. This technique is based on biochemical interaction of antigen-antibody or probe DNA-target DNA hybridization. A lateral flow assay (LFA) is composed of four parts: a sample pad, which is the area on which sample is dropped; conjugate pad, on which labeled tags combined with biorecognition elements; reaction membrane containing test line and control line for target DNA-probe DNA hybridization or antigen-antibody interaction; and absorbent pad, which reserves waste. For the construction of LFAs gold nanoparticles, colored latex beads, carbon nanoparticles, quantum dots, and enzymes are used as a label for increasing the sensitivity. In this work, the principle of LFAs, biorecognition elements, analytical performances, limits of detection (LODs), linear ranges of developed LFAs in different fields are summarized. Future perspectives in this area are also discussed.