Z
Zhendong Cao
Researcher at University of Pennsylvania
Publications - 16
Citations - 813
Zhendong Cao is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Chromatin & DNA repair. The author has an hindex of 9, co-authored 14 publications receiving 363 citations. Previous affiliations of Zhendong Cao include Peking University & National University of Singapore.
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Journal ArticleDOI
YY1 and CTCF orchestrate a 3D chromatin looping switch during early neural lineage commitment.
Jonathan A. Beagan,Michael Tran Duong,Katelyn R. Titus,Linda Zhou,Zhendong Cao,Jingjing Ma,Caroline V. Lachanski,Daniel R. Gillis,Jennifer E. Phillips-Cremins +8 more
TL;DR: The results support a model in which YY1 acts as an architectural protein to connect developmentally regulated looping interactions; the location of YY 1-mediated interactions may be demarcated in development by a preexisting topological framework created by constitutive CTCF- mediated interactions.
Journal ArticleDOI
H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
Yichao Cai,Ying Zhang,Yan Ping Loh,Jia Qi Tng,Mei Chee Lim,Zhendong Cao,Zhendong Cao,Anandhkumar Raju,Erez Lieberman Aiden,Shang Li,Lakshmanan Manikandan,Vinay Tergaonkar,Greg Tucker-Kellogg,Melissa J. Fullwood,Melissa J. Fullwood,Melissa J. Fullwood +15 more
TL;DR: In this paper, the authors investigate the hypothesis that H3K27me3-rich regions of the genome, defined from clusters of H 3K 27me3 peaks, may be used to identify silencers that can regulate gene expression via proximity or looping.
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In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer.
Zeyu Chen,Eri Arai,Omar Khan,Zhen Zhang,Shin Foong Ngiow,Yuan He,Hua Huang,Sasikanth Manne,Zhendong Cao,Amy E. Baxter,Zhangying Cai,Elizabeth Freilich,Mohammed Alkhatim A. Ali,Josephine R. Giles,Jennifer E. Wu,Allison R. Greenplate,Mohamed A. Hakeem,Qingzhou Chen,Makoto Kurachi,Kito Nzingha,Viktoriya Ekshyyan,Divij Mathew,Zhuoyu Wen,Nancy A. Speck,Alexis Battle,Shelley L. Berger,E. John Wherry,Junwei Shi +27 more
TL;DR: In this paper, the authors developed an in-vivo T-cell CRISPR screening platform and identified a key mechanism restraining TEFF biology through the ETS family TF, Fli1.
Posted ContentDOI
H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions
Yichao Cai,Ying Zhang,Yan Ping Loh,Jia Qi Tng,Mei Chee Lim,Zhendong Cao,Anandhkumar Raju,Shang Li,Lakshmanan Manikandan,Vinay Tergaonkar,Greg Tucker-Kellogg,Melissa J. Fullwood +11 more
TL;DR: H3K 27me3-rich regions of the genome defined from clusters of H3K27me3 peaks may be used to identify silencers that can regulate gene expression via proximity or looping and their mechanisms of functioning via looping are characterized.
Journal ArticleDOI
ALC1 links chromatin accessibility to PARP inhibitor response in homologous recombination-deficient cells
Priyanka Verma,Yeqiao Zhou,Zhendong Cao,Peter V. Deraska,Moniher Deb,Eri Arai,Weihua Li,Yue Shao,Laura N. Puentes,Yiwen Li,Sonali Patankar,Robert H. Mach,Robert B. Faryabi,Junwei Shi,Roger A. Greenberg +14 more
TL;DR: Using a CRISPR-based screen, this article identified the PAR-binding chromatin remodeller ALC1/CHD1L as a key determinant of PARPi toxicity in HR-deficient cells.