Z
Zheng Xu
Researcher at Hong Kong University of Science and Technology
Publications - 1
Citations - 133
Zheng Xu is an academic researcher from Hong Kong University of Science and Technology. The author has contributed to research in topics: TFEB & Autophagy. The author has an hindex of 1, co-authored 1 publications receiving 90 citations.
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A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition
Ju-Xian Song,Yueru Sun,Ivana Peluso,Yu Zeng,Xing Yu,Jia-Hong Lu,Zheng Xu,Mingzhong Wang,Liang-Feng Liu,Yingyu Huang,Lei-Lei Chen,Siva Sundara Kumar Durairajan,Hongjie Zhang,Bo Zhou,Hong Qi Zhang,Aiping Lu,Andrea Ballabio,Diego L. Medina,Zhihong Guo,Min Li +19 more
TL;DR: Curcumin derivative C1 is identified as a novel MTOR-independent activator of TFEB, which enhances autophagy and lysosome biogenesis in vitro and in vivo and is a potential therapeutic agent for the treatment of neurodegenerative diseases.