Zhenming Shen

TL;DR: Using low-coverage whole-genome sequencing of 5,303 Chinese women with recurrent MDD selected to reduce phenotypic heterogeneity, and 5,337 controls screened to exclude MDD, two loci contributing to risk of MDD on chromosome 10 are identified: one near the SIRT1 gene and the other in an intron of the LHPP gene.

TL;DR: Three subtypes were most consistently identified in analyses: severe, atypical and non-suicidal, which may represent a pathoplastic variant reflecting Chinese cultural influences.

TL;DR: Prior cross-cultural studies, factor analyses of MD in Western populations and empirical findings in this sample showing risk factor profiles similar to those seen inWestern populations suggest that the results are likely to be broadly representative of the human depressive syndrome.

TL;DR: CSA is strongly associated with recurrent MD and this association increases with greater severity of CSA, and among the depressed women, those with CSA had an earlier age of onset, longer depressive episodes.

TL;DR: Significantly more episodes of MDD occur among those with lower educational attainment (rather than longer episodes of disease), consistent with the hypothesis that the lower socioeconomic position increases the likelihood of developing MDD.