Zhishan Guo

Bio: Zhishan Guo is an academic researcher from University of Central Florida. The author has contributed to research in topics: Scheduling (computing) & Mixed criticality. The author has an hindex of 21, co-authored 107 publications receiving 1425 citations. Previous affiliations of Zhishan Guo include Tsinghua University & Missouri University of Science and Technology.

Analyses of allele-specific gene expression in highly divergent mouse crosses identifies pervasive allelic imbalance

Abstract: Complex human traits are influenced by variation in regulatory DNA through mechanisms that are not fully understood. Because regulatory elements are conserved between humans and mice, a thorough annotation of cis regulatory variants in mice could aid in further characterizing these mechanisms. Here we provide a detailed portrait of mouse gene expression across multiple tissues in a three-way diallel. Greater than 80% of mouse genes have cis regulatory variation. Effects from these variants influence complex traits and usually extend to the human ortholog. Further, we estimate that at least one in every thousand SNPs creates a cis regulatory effect. We also observe two types of parent-of-origin effects, including classical imprinting and a new global allelic imbalance in expression favoring the paternal allele. We conclude that, as with humans, pervasive regulatory variation influences complex genetic traits in mice and provide a new resource toward understanding the genetic control of transcription in mammals.

A One-Layer Recurrent Neural Network for Pseudoconvex Optimization Subject to Linear Equality Constraints

Abstract: In this paper, a one-layer recurrent neural network is presented for solving pseudoconvex optimization problems subject to linear equality constraints. The global convergence of the neural network can be guaranteed even though the objective function is pseudoconvex. The finite-time state convergence to the feasible region defined by the equality constraints is also proved. In addition, global exponential convergence is proved when the objective function is strongly pseudoconvex on the feasible region. Simulation results on illustrative examples and application on chemical process data reconciliation are provided to demonstrate the effectiveness and characteristics of the neural network.

Flexible and robust co-regularized multi-domain graph clustering

Abstract: Multi-view graph clustering aims to enhance clustering performance by integrating heterogeneous information collected in different domains. Each domain provides a different view of the data instances. Leveraging cross-domain information has been demonstrated an effective way to achieve better clustering results. Despite the previous success, existing multi-view graph clustering methods usually assume that different views are available for the same set of instances. Thus instances in different domains can be treated as having strict one-to-one relationship. In many real-life applications, however, data instances in one domain may correspond to multiple instances in another domain. Moreover, relationships between instances in different domains may be associated with weights based on prior (partial) knowledge. In this paper, we propose a flexible and robust framework, CGC (Co-regularized Graph Clustering), based on non-negative matrix factorization (NMF), to tackle these challenges. CGC has several advantages over the existing methods. First, it supports many-to-many cross-domain instance relationship. Second, it incorporates weight on cross-domain relationship. Third, it allows partial cross-domain mapping so that graphs in different domains may have different sizes. Finally, it provides users with the extent to which the cross-domain instance relationship violates the in-domain clustering structure, and thus enables users to re-evaluate the consistency of the relationship. Extensive experimental results on UCI benchmark data sets, newsgroup data sets and biological interaction networks demonstrate the effectiveness of our approach.

Animal models of human disease: zebrafish swim into view.

Abstract: Despite the pre-eminence of the mouse in modelling human disease, several aspects of murine biology limit its routine use in large-scale genetic and therapeutic screening. Many researchers who are interested in an embryologically and genetically tractable disease model have now turned to zebrafish. Zebrafish biology allows ready access to all developmental stages, and the optical clarity of embryos and larvae allow real-time imaging of developing pathologies. Sophisticated mutagenesis and screening strategies on a large scale, and with an economy that is not possible in other vertebrate systems, have generated zebrafish models of a wide variety of human diseases. This Review surveys the achievements and potential of zebrafish for modelling human diseases and for drug discovery and development.

Proceedings of the National Academy of Sciences

Abstract: where A represents the magnetic vector potential, is an integral of the hydromagnetic equations. This -integral made it possible to formulate a variational principle for the force-free magnetic fields. The integral expresses the fact that motions cannot transform a given field in an entirely arbitrary different field, if the conductivity of the medium isconsidered infinite. In this paper we shall show that the full set of hydromagnetic equations admit five more integrals, besides the energy integral, if dissipative processes are absent. These integrals, as we shall presently verify, are I2 =fbHvdV, (2)

SET-Valued Analysis

Abstract: “Multivalued Analysis” is the theory of set-valued maps (called multifonctions) and has important applications in many different areas. Multivalued analysis is a remarkable mixture of many different parts of mathematics such as point-set topology, measure theory and nonlinear functional analysis. It is also closely related to “Nonsmooth Analysis” (Chapter 5) and in fact one of the main motivations behind the development of the theory, was in order to provide necessary analytical tools for the study of problems in nonsmooth analysis. It is not a coincidence that the development of the two fields coincide chronologically and follow parallel paths. Today multivalued analysis is a mature mathematical field with its own methods, techniques and applications that range from social and economic sciences to biological sciences and engineering. There is no doubt that a modern treatise on “Nonlinear Functional Analysis” can not afford the luxury of ignoring multivalued analysis. The omission of the theory of multifunctions will drastically limit the possible applications.

Nonlinear Fractional Programming

Abstract: In this chapter we deal with the following nonlinear fractional programming problem: $$P:\mathop{{\max }}\limits_{{x \in s}} q(x) = (f(x) + \alpha )/((x) + \beta )$$ where f, g: R n → R, α, β ∈ R, S ⊆ R n . To simplify things, and without restricting the generality of the problem, it is usually assumed that, g(x) + β + 0 for all x ∈ S,S is non-empty and that the objective function has a finite optimal value.

Safeware: System Safety and Computers

Abstract: Will Tracz, our esteemed editor and Used-Program salesman, has written an entertaining, non-technical book dealing with the practice (and lack of) of software reuse. Its a collection of essays, mostly rehashed (reused?) and updated from various columns and papers published over the years.. Its a short (a bit over 200 pages) easy reading and enjoyable book (I read most of it in one sitting). Some of the essays discuss what was printed in the past and a discussion of the current status of the points.