Z
Zhishan Wang
Researcher at University of Kentucky
Publications - 51
Citations - 2568
Zhishan Wang is an academic researcher from University of Kentucky. The author has contributed to research in topics: Cancer & Metastasis. The author has an hindex of 25, co-authored 46 publications receiving 2093 citations. Previous affiliations of Zhishan Wang include Michigan State University & Emory University.
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Journal ArticleDOI
Wnt/beta-catenin signaling acts upstream of N-myc, BMP4, and FGF signaling to regulate proximal-distal patterning in the lung.
Weiguo Shu,Susan H. Guttentag,Zhishan Wang,Thomas Andl,Philip L. Ballard,Min Min Lu,Stefano Piccolo,Walter Birchmeier,Jeffrey A. Whitsett,Sarah E. Millar,Edward E. Morrisey +10 more
TL;DR: Wnt/beta-catenin signaling is a critical upstream regulator of proximal-distal patterning in the lung, in part, through regulation of N-myc, BMP4, and FGF signaling.
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Wnt/β-catenin signaling promotes expansion of Isl-1–positive cardiac progenitor cells through regulation of FGF signaling
Ethan D. Cohen,Zhishan Wang,John J. Lepore,Min Min Lu,Makoto Mark Taketo,Douglas J. Epstein,Edward E. Morrisey +6 more
TL;DR: What is believed to be a novel Wnt-FGF signaling axis required for expansion of Isl-1-positive AHF progenitors is revealed and future therapies to increase the number and function of these cells for cardiac regeneration are suggested.
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Wnt7b activates canonical signaling in epithelial and vascular smooth muscle cells through interactions with Fzd1, Fzd10, and LRP5.
TL;DR: Together, these data demonstrate that Wnt7b signals through Fzd1 and -10 and LRP5 and implicate these Wnt coreceptors in the regulation of lung airway and vascular development.
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Huntingtin forms toxic NH2-terminal fragment complexes that are promoted by the age-dependent decrease in proteasome activity
Hui Zhou,Fengli Cao,Zhishan Wang,Zhao-Xue Yu,Huu Phuc Nguyen,Joy Evans,Shihua Li,Xiao-Jiang Li +7 more
TL;DR: It is suggested that decreased proteasome activity contributes to late onset htt toxicity and that restoring the ability to remove NH2-terminal fragments will provide a more effective therapy for HD than inhibiting their production.
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Reversal and prevention of arsenic-induced human bronchial epithelial cell malignant transformation by microRNA-200b
Zhishan Wang,Yong Zhao,Eric Smith,Gregory J. Goodall,Paul A. Drew,Thomas Brabletz,Chengfeng Yang +6 more
TL;DR: Findings establish for the first time a causal role for depletion of miR-200b expression in human cell malignant transformation and tumor formation resulting from arsenic exposure.