Z
Zhixiang Wang
Researcher at University of Alberta
Publications - 89
Citations - 5050
Zhixiang Wang is an academic researcher from University of Alberta. The author has contributed to research in topics: Epidermal growth factor & Receptor tyrosine kinase. The author has an hindex of 32, co-authored 81 publications receiving 4130 citations. Previous affiliations of Zhixiang Wang include University of Toronto & McMaster University.
Papers
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Journal ArticleDOI
Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways.
Ping Wee,Zhixiang Wang +1 more
TL;DR: The molecular mechanisms that regulate EGFR signal transduction are reviewed, including the EGFR structure and its mutations, ligand binding and EGFR dimerization, as well as the signaling pathways that lead to G1 cell cycle progression.
Journal ArticleDOI
Endosomal Signaling of Epidermal Growth Factor Receptor Stimulates Signal Transduction Pathways Leading to Cell Survival
TL;DR: Establishment of a system to specifically activate epidermal growth factor (EGF) receptor (EGFR) when it endocytoses into endosomes is reported, providing original evidence demonstrating that the endosome can serve as a nucleation site for the formation of signaling complexes.
Book ChapterDOI
ErbB Receptors and Cancer
TL;DR: The ErbB receptor family, also known as the EGF receptor family or type I receptorfamily, includes the epidermal growth factor (EGF) receptor (EGFR), which has been the primary choices as targets for developing cancer therapies.
Journal ArticleDOI
Endocytosis Deficiency of Epidermal Growth Factor (EGF) Receptor–ErbB2 Heterodimers in Response to EGF Stimulation
TL;DR: The results indicate that ErbB2 and the EGFR-ErbBB2 heterodimers are impaired in EGF-induced endocytosis, which is due to the sequence of its intracellular domain.
Journal ArticleDOI
Grb2 and Shc Adapter Proteins Play Distinct Roles in Neu (ErbB-2)-Induced Mammary Tumorigenesis: Implications for Human Breast Cancer
David Dankort,Bart M. Maslikowski,Neil Warner,Nubufumi Kanno,Harold Kim,Zhixiang Wang,Michael Moran,Robert G. Oshima,Robert D. Cardiff,William J. Muller +9 more
TL;DR: It is argued that Grb2 and Shc play important and distinct roles in ErbB-2/Neu-induced mammary tumorigenesis and metastasis.