Z
Zhu Guo
Researcher at National Center for Immunization and Respiratory Diseases
Publications - 33
Citations - 2426
Zhu Guo is an academic researcher from National Center for Immunization and Respiratory Diseases. The author has contributed to research in topics: Virus & Neuraminidase. The author has an hindex of 18, co-authored 31 publications receiving 2166 citations. Previous affiliations of Zhu Guo include Centers for Disease Control and Prevention.
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Journal ArticleDOI
New world bats harbor diverse influenza A viruses.
Suxiang Tong,Xueyong Zhu,Yan Li,Mang Shi,Jing Zhang,Melissa Bourgeois,Hua Yang,Xianfeng Chen,Sergio Recuenco,Jorge Gomez,Li-Mei Chen,Adam Johnson,Ying Tao,C. Dreyfus,Wenli Yu,Ryan McBride,Paul J. Carney,Amy T. Gilbert,Jessie Chang,Zhu Guo,Charles T. Davis,James C. Paulson,James Stevens,Charles E. Rupprecht,Charles E. Rupprecht,Edward C. Holmes,Edward C. Holmes,Ian A. Wilson,Ruben O. Donis +28 more
TL;DR: Using consensus degenerate RT-PCR, a novel influenza A virus is identified in a flat-faced fruit bat from Peru, indicating that bats constitute a potentially important and likely ancient reservoir for a diverse pool of influenza viruses.
Journal ArticleDOI
NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I.
Zhu Guo,Li-Mei Chen,Hui Zeng,Jorge A. Gomez,Julie Plowden,Takashi Fujita,Jacqueline M. Katz,Ruben O. Donis,Suryaprakash Sambhara +8 more
TL;DR: It is demonstrated that RIG-I is required for induction of IFN-I in an IAV-infected human lung epithelial cell line and further information is provided on the mechanism by which IAV NS1 antagonizes the host antiviral response.
Journal ArticleDOI
Crystal structures of two subtype N10 neuraminidase-like proteins from bat influenza A viruses reveal a diverged putative active site
Xueyong Zhu,Hua Yang,Zhu Guo,Wenli Yu,Paul J. Carney,Yan Li,Li-Mei Chen,James C. Paulson,Ruben O. Donis,Suxiang Tong,James Stevens,Ian A. Wilson +11 more
TL;DR: Structural features and the fact that the recombinant N10 protein exhibits no, or extremely low, NA activity suggest that it may have a different function than the NA proteins of other influenza viruses.
Journal ArticleDOI
Influenza virus exploits tunneling nanotubes for cell-to-cell spread
Amrita Kumar,Jin Hyang Kim,Priya Ranjan,Maureen G. Metcalfe,Weiping Cao,Margarita Mishina,Shivaprakash Gangappa,Zhu Guo,Edward S. Boyden,Sherif R. Zaki,Ian A. York,Adolfo García-Sastre,Michael W. Shaw,Suryaprakash Sambhara +13 more
TL;DR: Evidence is presented that lung epithelial cells are connected by TNTs, and in spite of the presence of neutralizing antibodies and an antiviral agent, Oseltamivir, influenza virus can exploit these networks to transfer viral proteins and genome from the infected to naïve cell, resulting in productive viral replication in the naïve cells.
Journal ArticleDOI
The development of vaccine viruses against pandemic A(H1N1) influenza
James S. Robertson,Carolyn Nicolson,Ruth Harvey,Rachel E. Johnson,Diane Major,Kate Guilfoyle,Sarah Roseby,R.W. Newman,Rebecca Collin,Chantal Wallis,Othmar G. Engelhardt,John Wood,Jianhua Le,Ramanunninair Manojkumar,Barbara A. Pokorny,Jeanmarie Silverman,Rene Devis,Doris Bucher,Erin E. Verity,Catherine Agius,Sarina Camuglia,Chi Ong,Steven Rockman,Anne Curtis,Peter Schoofs,Olga Zoueva,Hang Xie,Xing Li,Zhengshi Lin,Zhiping Ye,Li-Mei Chen,Eduardo O’Neill,Amanda Balish,Aleksandr S. Lipatov,Zhu Guo,Irina Isakova,Charles T. Davis,Pierre Rivailler,Kortney M. Gustin,Jessica A. Belser,Taronna R. Maines,Terrence M. Tumpey,Xiyan Xu,Jacqueline M. Katz,Alexander Klimov,Nancy J. Cox,Ruben O. Donis +46 more
TL;DR: The development and the characteristics of current pandemic H1N1 candidate vaccine viruses are described and the classical reassortment approach and the more recent reverse genetics approach are described.