Z
Ziad Mallat
Researcher at University of Cambridge
Publications - 383
Citations - 30053
Ziad Mallat is an academic researcher from University of Cambridge. The author has contributed to research in topics: Inflammation & Immune system. The author has an hindex of 83, co-authored 360 publications receiving 26780 citations. Previous affiliations of Ziad Mallat include Maastricht University Medical Centre & University of Paris.
Papers
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Journal ArticleDOI
Cytokines in atherosclerosis: pathogenic and regulatory pathways.
Alain Tedgui,Ziad Mallat +1 more
TL;DR: Based on the current knowledge of the role of cytokines in atherosclerosis, some novel therapeutic strategies to combat this disease are proposed and the potential of circulating cytokine levels as biomarkers of coronary artery disease is discussed.
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Natural regulatory T cells control the development of atherosclerosis in mice.
Hafid Ait-Oufella,Benoît L. Salomon,Stephane Potteaux,Anna-Karin L. Robertson,Pierre Gourdy,Joffrey Zoll,Régine Merval,Bruno Esposito,José L. Cohen,Sylvain Fisson,Richard A. Flavell,Göran K. Hansson,David Klatzmann,Alain Tedgui,Ziad Mallat +14 more
TL;DR: It is shown that naturally arising CD4+CD25+ regulatory T cells, which actively maintain immunological tolerance to self and nonself antigens, are powerful inhibitors of atherosclerosis in several mouse models.
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Elevated levels of shed membrane microparticles with procoagulant potential in the peripheral circulating blood of patients with acute coronary syndromes.
Ziad Mallat,Benamer H,Bénédicte Hugel,Joelle Benessiano,Phillippe Gabriel Steg,Freyssinet Jm,Alain Tedgui +6 more
TL;DR: High levels of procoagulant endothelial microparticles are present in the circulating blood of patients with ACS and may contribute to the generation and perpetuation of intracoronary thrombi.
Journal ArticleDOI
Protective role of interleukin-10 in atherosclerosis
Ziad Mallat,Sandrine Besnard,Micheline Duriez,Virginie Deleuze,Florence Emmanuel,Michel Bureau,Fabienne Soubrier,Bruno Esposito,Hélène Duez,Catherine Fievet,Bart Staels,Nicolas Duverger,Daniel Scherman,Alain Tedgui +13 more
TL;DR: It is shown that IL-10-deficient C57BL/6J mice fed an atherogenic diet and raised under specific pathogen-free conditions exhibit a significant 3-fold increase in lipid accumulation compared with wild-type mice, which underscores the critical roles ofIL-10 in both atherosclerotic lesion formation and stability.
Journal ArticleDOI
Shed Membrane Microparticles With Procoagulant Potential in Human Atherosclerotic Plaques A Role for Apoptosis in Plaque Thrombogenicity
TL;DR: It is indicated that shed membrane microparticles with procoagulant potential are produced in human atherosclerotic plaques and could be a critical determinant of plaque thrombogenicity after plaque rupture.