Z
Ziedulla Abdullaev
Researcher at National Institutes of Health
Publications - 53
Citations - 6624
Ziedulla Abdullaev is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 19, co-authored 25 publications receiving 5884 citations. Previous affiliations of Ziedulla Abdullaev include Government of the United States of America & University Hospital of Lausanne.
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Journal ArticleDOI
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD
Alan E. Renton,Elisa Majounie,Adrian James Waite,Javier Simón-Sánchez,Javier Simón-Sánchez,Sara Rollinson,J. Raphael Gibbs,J. Raphael Gibbs,Jennifer C. Schymick,Hannu Laaksovirta,John C. van Swieten,John C. van Swieten,Liisa Myllykangas,Hannu Kalimo,Anders Paetau,Yevgeniya Abramzon,Anne M. Remes,Alice Kaganovich,Sonja W. Scholz,Sonja W. Scholz,Sonja W. Scholz,Jamie Duckworth,Jinhui Ding,Daniel W. Harmer,Dena G. Hernandez,Dena G. Hernandez,Janel O. Johnson,Janel O. Johnson,Kin Y. Mok,Mina Ryten,Danyah Trabzuni,Rita Guerreiro,Richard W. Orrell,James Neal,Alexandra Murray,J. P. Pearson,Iris E. Jansen,David Sondervan,Harro Seelaar,Derek J. Blake,Kate Young,Nicola Halliwell,Janis Bennion Callister,Greg Toulson,Anna Richardson,Alexander Gerhard,Julie S. Snowden,David M. A. Mann,David Neary,Mike A. Nalls,Terhi Peuralinna,Lilja Jansson,Veli-Matti Isoviita,Anna-Lotta Kaivorinne,Maarit Hölttä-Vuori,Elina Ikonen,Raimo Sulkava,Michael Benatar,Joanne Wuu,Adriano Chiò,Gabriella Restagno,Giuseppe Borghero,Mario Sabatelli,David Heckerman,Ekaterina Rogaeva,Lorne Zinman,Jeffrey D. Rothstein,Michael Sendtner,Carsten Drepper,Evan E. Eichler,Can Alkan,Ziedulla Abdullaev,Svetlana Pack,Amalia Dutra,Evgenia Pak,John Hardy,Andrew B. Singleton,Nigel Williams,Peter Heutink,Stuart Pickering-Brown,Huw R. Morris,Huw R. Morris,Huw R. Morris,Pentti J. Tienari,Bryan J. Traynor,Bryan J. Traynor +85 more
TL;DR: The chromosome 9p21 amyotrophic lateral sclerosis-frontotemporal dementia (ALS-FTD) locus contains one of the last major unidentified autosomal-dominant genes underlying these common neurodegenerative diseases, and a large hexanucleotide repeat expansion in the first intron of C9ORF72 is shown.
Journal ArticleDOI
Analysis of the Vertebrate Insulator Protein CTCF-Binding Sites in the Human Genome
Tae Hoon Kim,Ziedulla Abdullaev,Andrew D. Smith,Keith A. Ching,Dmitri Loukinov,Roland Green,Michael Q. Zhang,Victor V. Lobanenkov,Bing Ren +8 more
TL;DR: 13,804 CTCF-binding sites in potential insulators of the human genome are described, discovered experimentally in primary human fibroblasts and fit to a consensus motif highly conserved and suitable for predicting possible insulators driven by CTCf in other vertebrate genomes.
Journal ArticleDOI
Conditional Expression of the CTCF-Paralogous Transcriptional Factor BORIS in Normal Cells Results in Demethylation and Derepression of MAGE-A1 and Reactivation of Other Cancer-Testis Genes
Sergei Vatolin,Ziedulla Abdullaev,Svetlana Pack,Patrick T. Flanagan,Mary C. Custer,Dmitri Loukinov,Elena M. Pugacheva,Julie A. Hong,Herbert C. Morse,David S. Schrump,John I. Risinger,J. Carl Barrett,Victor V. Lobanenkov +12 more
TL;DR: It is suggested that BORIS is likely tethering epigenetic machinery to a novel class of CTCF/BORIS 11ZF target sequences that mediate induction of cancer-testis genes.
Journal ArticleDOI
Reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter coincides with derepression of this cancer-testis gene in lung cancer cells.
Julie A. Hong,Yang Kang,Ziedulla Abdullaev,Patrick T. Flanagan,Svetlana Pack,Maria R. Fischette,Mina T. Adnani,Dmitri Loukinov,Sergei Vatolin,John I. Risinger,Mary C. Custer,G. Aaron Chen,Ming Zhao,Dao M. Nguyen,J. Carl Barrett,Victor V. Lobanenkov,David S. Schrump +16 more
TL;DR: Rec reciprocal binding of CTCF and BORIS to the NY-ESO-1 promoter mediates epigenetic regulation of this CT gene in lung cancer cells, and suggest that induction of BORis may be a novel strategy to augment immunogenicity of pulmonary carcinomas.
Journal ArticleDOI
Dual role of DNA methylation inside and outside of CTCF-binding regions in the transcriptional regulation of the telomerase hTERT gene
Stéphanie Renaud,Dmitri Loukinov,Ziedulla Abdullaev,Isabelle Guilleret,Fred T. Bosman,Victor V. Lobanenkov,Jean Benhattar +6 more
TL;DR: HTERT methylation prevents binding of the CTCF repressor, but partial hypomethylation of the core promoter is necessary for hTERT expression.