An inverse approach to the accurate modelling of 3D-printed sandwich panels with lattice core using beams of variable cross-section

In this paper, a topology optimization framework for continuous composite fiber three-dimensional (3D) printing is presented. The problem of compliance minimization with respect to the design parameters of density and orientation is formulated and solved numerically using the proposed filtration procedure, ensuring a smooth fiber orientation change and fast convergence. The optimization algorithm is based on the gradient method and implemented using Abaqus finite-element analysis software. It allows optimization of parts within complex computer-aided design models and considers different types of nonlinearities in the finite-element model. The efficiency of the proposed method is evaluated on examples of two-dimensional (2D) and 3D cantilevers, which reveals the general similarity of the resulting shapes in 2D and 3D. Nevertheless, spatially oriented trusses are clearly defined in the result part of the 3D problem. The pedal support of a race car is optimized using the developed framework with an optimization domain based on the geometry of the conventional metallic structure. The resulting topology and fiber orientation are postprocessed using special software for printing trajectory generation and produced by a continuous composite fiber 3D printer.

Optimization of parts manufactured using continuous fiber three-dimensional printing technology

Manufacturable insight into modelling and design considerations in fibre-steered composite laminates: state of the art and perspective

A parametric divergence-free vector field method for the optimization of composite structures with curvilinear fibers

Topology optimization with discrete geometric components made of composite materials

Optimization of variable stiffness laminates with gap-overlap and curvature constraints

Preparation and characterization of a novel intelligent starch/gelatin binary film containing purple sweet potato anthocyanins for Flammulina velutipes mushroom freshness monitoring.

In this study, the hepatoprotective effect of alkali extract (NE) of water bamboo shoot (WBS) against acute alcoholic liver injury (ALI) in mice was evaluated, and its underlying mechanisms were explored. Animal experiment demonstrated that NE exhibited hepatoprotective effect on alcoholic intake-induced ALI via significantly enhancing the hepatic activities of alcohol dehydrogenase (ADH), acetaldehyde dehydrogenase (ALDH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT), whereas significantly attenuated hepatic levels of malondialdehyde (MDA), interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). The potential molecular mechanism and bioactive compounds of NE against ALI were explored by bioinformatics analysis and isosinensetin was found to be the major bioactive compounds in NE against ALI. The western blot analysis showed that NE inhibited phosphorylation of p65 and IκBα to suppress the NF-κB pathway. Overall our result indicated that WBS possesses potential hepatoprotective effects against ALI. 

https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/fft2.217

Hepatoprotective effect of water bamboo shoot (
 Zizania latifolia
 ) extracts against acute alcoholic liver injury in a mice model and screening of bioactive phytochemicals

Zihao Zong

Papers

Optimization of variable stiffness laminates with gap-overlap and curvature constraints

Preparation and characterization of a novel intelligent starch/gelatin binary film containing purple sweet potato anthocyanins for Flammulina velutipes mushroom freshness monitoring.

Hepatoprotective effect of water bamboo shoot ( Zizania latifolia ) extracts against acute alcoholic liver injury in a mice model and screening of bioactive phytochemicals

Purification and characterization of cutinase from Botrytis cinerea and effect on blueberry cuticle