Z
Zihua Wang
Researcher at Cold Spring Harbor Laboratory
Publications - 60
Citations - 4801
Zihua Wang is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Drug delivery & Population. The author has an hindex of 20, co-authored 56 publications receiving 3936 citations. Previous affiliations of Zihua Wang include Center for Excellence in Education & National University of Singapore.
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Journal ArticleDOI
The contribution of de novo coding mutations to autism spectrum disorder
Ivan Iossifov,Brian J. O'Roak,Stephen Sanders,Stephen Sanders,Michael Ronemus,Niklas Krumm,Dan Levy,Holly A.F. Stessman,Kali Witherspoon,Laura Vives,Karynne E. Patterson,Joshua D. Smith,Bryan W. Paeper,Deborah A. Nickerson,Jeanselle Dea,Shan Dong,Shan Dong,Luis E. Gonzalez,Jeffrey D. Mandell,Shrikant Mane,Michael T. Murtha,Catherine A.W. Sullivan,Michael F. Walker,Zainulabedin Waqar,Liping Wei,A. Jeremy Willsey,A. Jeremy Willsey,Boris Yamrom,Yoon-ha Lee,Ewa A. Grabowska,Ertugrul Dalkic,Ertugrul Dalkic,Zihua Wang,Steven Marks,Peter Andrews,Anthony Leotta,Jude Kendall,Inessa Hakker,Julie Rosenbaum,Beicong Ma,Linda Rodgers,Jennifer Troge,Giuseppe Narzisi,Seungtai Yoon,Michael C. Schatz,Kenny Ye,W. Richard McCombie,Jay Shendure,Evan E. Eichler,Evan E. Eichler,Matthew W. State,Matthew W. State,Michael Wigler +52 more
TL;DR: It is estimated that LGD mutation in about 400 genes can contribute to the joint class of affected females and males of lower IQ, with an overlapping and similar number of genes vulnerable to contributory missense mutation.
Journal ArticleDOI
De Novo Gene Disruptions in Children on the Autistic Spectrum
Ivan Iossifov,Michael Ronemus,Dan Levy,Zihua Wang,Inessa Hakker,Julie Rosenbaum,Boris Yamrom,Yoon-ha Lee,Giuseppe Narzisi,Anthony Leotta,Jude Kendall,Ewa A. Grabowska,Beicong Ma,Steven Marks,Linda Rodgers,Asya Stepansky,Jennifer Troge,Peter Andrews,Mitchell A. Bekritsky,Kith Pradhan,Elena Ghiban,Melissa Kramer,Jennifer Parla,Ryan Demeter,Lucinda Fulton,Robert S. Fulton,Vincent Magrini,Kenny Ye,Jennifer C. Darnell,Robert B. Darnell,Robert B. Darnell,Elaine R. Mardis,Richard K. Wilson,Michael C. Schatz,Richard W. McCombie,Michael Wigler +35 more
TL;DR: Exome sequencing of 343 families, each with a single child on the autism spectrum and at least one unaffected sibling, reveals de novo small indels and point substitutions, which suggest FMRP-associated genes are especially dosage-sensitive targets of cognitive disorders.
Journal ArticleDOI
Accurate de novo and transmitted indel detection in exome-capture data using microassembly
Giuseppe Narzisi,Jason O'Rawe,Ivan Iossifov,Han Fang,Yoon-ha Lee,Zihua Wang,Yiyang Wu,Gholson J. Lyon,Michael Wigler,Michael C. Schatz +9 more
TL;DR: Scalpel's power to detect long (≥30 bp) transmitted events and enrichment for de novo likely gene-disrupting indels in autistic children and a detailed repeat analysis coupled with a self-tuning k-mer strategy allows Scalpel to outperform other state-of-the-art approaches for indel discovery.
Journal ArticleDOI
Indel variant analysis of short-read sequencing data with Scalpel
Han Fang,Han Fang,Ewa A. Bergmann,Kanika Arora,Vladimir Vacic,Michael C. Zody,Ivan Iossifov,Jason O'Rawe,Jason O'Rawe,Yiyang Wu,Yiyang Wu,Laura T Jimenez Barron,Laura T Jimenez Barron,Julie Rosenbaum,Michael Ronemus,Yoon-ha Lee,Zihua Wang,Esra Dikoglu,Vaidehi Jobanputra,Gholson J. Lyon,Gholson J. Lyon,Michael Wigler,Michael C. Schatz,Michael C. Schatz,Giuseppe Narzisi +24 more
TL;DR: This protocol describes how to use Scalpel to perform highly accurate indel calling from whole-genome and whole-exome sequencing data and provides detailed instructions for an exemplary family-based de novo study.
Journal ArticleDOI
Energy Migration Engineering of Bright Rare-Earth Upconversion Nanoparticles for Excitation by Light-Emitting Diodes
TL;DR: The benefit of the novel LED-excited UCNPs is demonstrated by imaging of breast cancer cells and enabling an economic handheld semiquantitative visual measurement device.