Z
Ziyuan Ma
Researcher at University of Pennsylvania
Publications - 12
Citations - 417
Ziyuan Ma is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Kidney disease & Genome-wide association study. The author has an hindex of 5, co-authored 12 publications receiving 66 citations.
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Journal ArticleDOI
Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets.
Zhen Miao,Michael S. Balzer,Ziyuan Ma,Hongbo Liu,Junnan Wu,Rojesh Shrestha,Tamás Arányi,Amy Kwan,Ayano Kondo,Marco Pontoglio,Junhyong Kim,Mingyao Li,Klaus H. Kaestner,Katalin Susztak +13 more
TL;DR: In this article, the authors profile open chromatin and gene expression in developing and adult mouse kidneys at single cell resolution and reveal key cell type-specific transcription factors and major gene-regulatory circuits for kidney cells.
Journal ArticleDOI
Mapping the genetic architecture of human traits to cell types in the kidney identifies mechanisms of disease and potential treatments.
Xin Sheng,Yuting Guan,Ziyuan Ma,Junnan Wu,Hongbo Liu,Chengxiang Qiu,Steven Vitale,Zhen Miao,Matthew J. Seasock,Matthew Palmer,Myung K. Shin,Kevin L. Duffin,Steven S. Pullen,Todd L. Edwards,Jacklyn N. Hellwege,Adriana M. Hung,Mingyao Li,Benjamin F. Voight,Thomas M. Coffman,Christopher D. Brown,Katalin Susztak +20 more
TL;DR: In this paper, the authors generated comprehensive maps of expression quantitative trait loci (eQTLs) for 659 microdissected human kidney samples and identified cell-type eQTL by mapping interactions between cell type abundances and genotypes.
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Urinary Single-Cell Profiling Captures the Cellular Diversity of the Kidney.
Amin Abedini,Yuan O. Zhu,Shatakshee Chatterjee,Gabor Halasz,Kishor Devalaraja-Narashimha,Rojesh Shrestha,Michael S. Balzer,Jihwan Park,Tong Zhou,Ziyuan Ma,Katie Marie Sullivan,Hailong Hu,Xin Sheng,Hongbo Liu,Yi Wei,Carine M. Boustany-Kari,Uptal D. Patel,Salem Almaani,Matthew Palmer,Raymond R. Townsend,Shira J. Blady,Jonathan J. Hogan,Morton Lori C,Katalin Susztak +23 more
TL;DR: In this paper, single-cell transcriptomic analysis was performed on 17 urine samples obtained from five subjects at two different occasions, using both spot and 24-hour urine collection, and a pooled urine sample from multiple healthy individuals served as a reference control.
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Transcriptome-wide association analysis identifies DACH1 as a kidney disease risk gene that contributes to fibrosis
Tomohito Doke,Shizheng Huang,Chengxiang Qiu,Hongbo Liu,Yuting Guan,Hailong Hu,Ziyuan Ma,Junnan Wu,Zhen Miao,Xin Sheng,Jianfu Zhou,Aili Cao,Jianhua Li,Lewis Kaufman,Adriana M. Hung,Christopher D. Brown,Richard G. Pestell,Katalin Susztak +17 more
TL;DR: In this paper, the authors identified Dachshund homolog 1 (DACH1), a cell-fate determination factor, as a kidney disease risk gene using transcriptome-wide association studies (TWAS), summary Mendelian randomization and MetaXcan.
Journal ArticleDOI
The key role of NLRP3 and STING in APOL1-associated podocytopathy
Junnan Wu,Archana Raman,Nathan J Coffey,Xin Sheng,Joseph Wahba,Matthew J. Seasock,Ziyuan Ma,Pazit Beckerman,Dorottya Laczkó,Matthew Palmer,Jeffrey B. Kopp,Jay J. Kuo,Steven S. Pullen,Carine M. Boustany-Kari,Andreas Linkermann,Katalin Susztak +15 more
TL;DR: In this article, the authors reported that expression of G2 APOL1 in the podocytes of Nphs1rtTA/TRE-G2APOL1 mice leads to early activation of the cytosolic nucleotide sensor, stimulator of interferon genes (STING), and the NLR family pyrin domain-containing 3 (NLRP3) inflammasome.