Z
Zoe Arvanitakis
Researcher at Rush University Medical Center
Publications - 117
Citations - 14105
Zoe Arvanitakis is an academic researcher from Rush University Medical Center. The author has contributed to research in topics: Dementia & Alzheimer's disease. The author has an hindex of 44, co-authored 104 publications receiving 11373 citations. Previous affiliations of Zoe Arvanitakis include Mayo Clinic & University of Manitoba.
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Journal ArticleDOI
Mixed brain pathologies account for most dementia cases in community-dwelling older persons
TL;DR: The majority of community-dwelling older persons have brain pathology, and those with dementia most often have multiple brain pathologies, which greatly increases the odds of dementia.
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Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
Konrad Talbot,Hoau-Yan Wang,Hala Kazi,Li-Ying Han,Kalindi Bakshi,Andres Stucky,Robert L. Fuino,Krista R. Kawaguchi,Andrew J. Samoyedny,Robert S. Wilson,Zoe Arvanitakis,Julie A. Schneider,Bryan A. Wolf,David A. Bennett,John Q. Trojanowski,Steven E. Arnold +15 more
TL;DR: Brain insulin resistance appears to be an early and common feature of AD, a phenomenon accompanied by IGF-1 resistance and closely associated with IRS-1 dysfunction potentially triggered by Aβ oligomers and yet promoting cognitive decline independent of classic AD pathology.
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Diabetes mellitus and risk of Alzheimer disease and decline in cognitive function.
TL;DR: Diabetes mellitus may be associated with an increased risk of developing AD and may affect cognitive systems differentially, and this study evaluated the association of diabetes mellitus with risk of AD and change in different cognitive systems.
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Neuropathology of older persons without cognitive impairment from two community-based studies
David A. Bennett,Julie A. Schneider,Zoe Arvanitakis,Jeremiah F. Kelly,Neelum T. Aggarwal,Raj C. Shah,Robert S. Wilson +6 more
TL;DR: Alzheimer disease pathology can be found in the brains of older persons without dementia or mild cognitive impairment and is related to subtle changes in episodic memory.
Journal ArticleDOI
Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums
Steven E. Arnold,Zoe Arvanitakis,Shannon L. Macauley-Rambach,Aaron M. Koenig,Hoau Yan Wang,Rexford S. Ahima,Suzanne Craft,Sam Gandy,Christoph Buettner,Luke E. Stoeckel,David M. Holtzman,David M. Nathan +11 more
TL;DR: Key observations and experimental data on insulin signalling in the brain are reviewed and the concept of 'brain insulin resistance' is defined and the growing, although still inconsistent, literature concerning cognitive impairment and neuropathological abnormalities in T2DM, obesity and insulin resistance is reviewed.