Zohreh Taheri

Bio: Zohreh Taheri is an academic researcher from Tarbiat Modares University. The author has contributed to research in topics: Sulfonyl & Nitrile. The author has an hindex of 5, co-authored 14 publications receiving 43 citations.

A Convenient Synthesis of Tetrasubstituted Pyrazoles from Nitrile Imines and 2-(Thioxothiazolidin-5-ylidene)acetates

Abstract: Alkyl 2-(3-alkyl-4-oxo-2-thioxothiazolidin-5-ylidene)acetates react with hydrazonoyl chlorides in the presence of triethylamine to ­afford tetrasubstituted pyrazole derivatives. Formally, this transformation is regarded as a 1,3-dipolar cycloaddition of the exocyclic carbon–carbon double bond of the thioxothiazolidine derivatives with nitrile imines generated in situ. This efficient method provides fast access to a range of structurally diverse pyrazoles. The structure of a typical product is confirmed by X-ray crystallography.

A convenient synthesis of spiroindolo[2,1-b]quinazoline-6,2′-[1,3,4]oxadiazoles from tryptanthrin and nitrile imines

Abstract: A convenient method for the synthesis of functionalized spiroindolo[2,1-b]quinazoline-6,2′-[1,3,4]oxadiazoles from indolo[2,1-b]quinazoline-6,12-diones and 13 hydrazonoyl chlorides in refluxing MeCN is described. These transformations are highlighted by inert atmosphere and lack of activator or metal promoters.

Synthesis of thia- and thioxo-tetraazaspiro[4.4]nonenones from nitrile imines and arylidenethiohydantoins.

Abstract: 5-Arylidene-1-methyl-2-thiohydantoins undergo [3+2]-cycloaddition reaction with nitrile imines, generated in situ from hydrazonyl chlorides, at C=C and C=S dipolarophiles in the thiohydantoin moiety to afford thioxo-tetraazaspiro[4.4]nonenones and thia-tetraazaspiro[4.4]nonenones in moderate to good yields. The stereochemistry of these spiroheterocycles has been confirmed by X-ray diffraction studies.

Sulfonyl Ketenimines as Key Intermediates in One-Pot Synthesis of N-Sulfonyl-2-alkaneimidoyl Selenocyanates

Abstract: Sulfonyl-ketenimine intermediates, generated by the addition of Cu acetylides to sulfonyl azides, are trapped by KSeCN to afford N-sulfonyl-2-alkaneimidoyl selenocyanates in moderate-to-good yields.

Copper-Catalyzed Tandem Synthesis of Pentasubstituted Pyridines from Sulfonoketenimides and 2-Aminoprop-1-ene-1,1,3-tricarbonitrile

Abstract: Fully substituted pyridines were synthesized in moderate to good yields in a one-pot process by the copper-catalyzed sequential reaction of sulfonyl azides with terminal alkynes and 2-aminoprop-1-ene-1,1,3-tricarbonitrile at room temperature.

Malononitrile dimer as a privileged reactant in design and skeletal diverse synthesis of heterocyclic motifs

Abstract: Malononitrile dimer as a precursor reactant has been extensively applied in the diversity-oriented synthesis of various heterocyclic motifs, bis-heterocyclic compounds, fused heterocycle derivatives, bicyclic bridged heterocyclic scaffolds, and highly substituted carbocyclic compounds. These remarkable products were synthesized via various types of reactions, such as cycloaddition, cyclocondensation, cascade/domino/tandem reactions along with multi-component reactions. In addition, the flexibility and high reactivity of malononitrile dimer as a multi-functional reagent and its potential to the preparation of novel beneficial scaffolds as well as biologically active molecules signify it as a suitable building block in total synthesis, medicinal chemistry, and dyes. In the present review, the advances in the chemistry of malononitrile dimer as a potent reagent in organic synthesis have been reported in the past to now.

Heterocyclization reactions using malononitrile dimer (2-aminopropene-1,1,3-tricarbonitrile)

Abstract: In this work, we provide the first generalized and critical analysis of data on the chemistry of malononitrile dimer (2-aminopropene-1,1,3-tricarbonitrile) – a multifunctional reagent that is widely used for the preparation of diverse heterocyclic systems. The majority of references are from the last 20–25 years.

Theoretical model study of adsorbed antimalarial-graphene dimers: doping effects, photophysical parameters, intermolecular interactions, edge adsorption, and SERS.

Abstract: Future diagnostics and therapy applications are in part riding on the discovery and implementation of new optical techniques and strategies (which often derive from dyads) for example, prediction of features in surface-enhanced Raman spectroscopy requires the study of chromophore-chromophore interactions involve intermolecular forces, drug delivery, and photo mechanisms which are of great interest. New matches between chromophore systems (i.e. FRET), and π-delocalized surfaces are important to study. We explore low-molecular weight drug molecules and their interaction with the reporter material/surface of graphene. Bonding, charge transfer and orbital interactions for 2-amino-5-(1-methyl-5-nitro-2-imidazolyl)-1,3,4-thiadiazole (megazol or AMIT) on graphene were carried out. The graphene model substrate was monotonically/monatomically substituted (doped) with one neutral heteroatom (N/O/S/B) in place of one carbon center; chemical adsorption of AMIT is due to charge transfer from doped graphene to AMIT (DFT). Our AMIT-nanocluster studies show that the nanoclusters will act as a sensor component for the detection of drugs due to SERS. Our findings identified that the greater the energy of the charge transfer, the stronger the calculated chemical adsorption. Additionally, charge transfer is highest for the N-doped systems and least for pristine graphene, resulting in a stronger adsorption energy for N-doped graphene. Mulliken charge analysis of structures confirms enhancement found in QD-AMIT systems.Communicated by Ramaswamy H. Sarma.