Z
Zoltán A. Tökés
Researcher at University of Southern California
Publications - 45
Citations - 2428
Zoltán A. Tökés is an academic researcher from University of Southern California. The author has contributed to research in topics: Glycoprotein & Liposome. The author has an hindex of 24, co-authored 45 publications receiving 2364 citations. Previous affiliations of Zoltán A. Tökés include Children's Hospital Los Angeles.
Papers
More filters
Journal ArticleDOI
Matrix metalloproteinase-9 (MMP-9) is synthesized in neurons of the human hippocampus and is capable of degrading the amyloid-beta peptide (1-40).
TL;DR: These results establish that neurons have the capacity to synthesize MMP-9, which, on activation, may degrade extracellular substrates such as β-amyloid.
Journal ArticleDOI
Synthesis, Biological Evaluation, and Quantitative Structure−Activity Relationship Analysis of New Schiff Bases of Hydroxysemicarbazide as Potential Antitumor Agents†
Shijun Ren,Rubin Wang,Kenichi Komatsu,Patricia Bonaz-Krause,Yegor Zyrianov,Charles E. McKenna,Csaba Csipke,Zoltán A. Tökés,Eric J. Lien +8 more
TL;DR: Quantitative structure-activity relationship (QSAR) analysis showed that, besides the essential pharmacophore (-NHCONHOH), hydrophobicity, molecular size/polarizability, and the presence of an oxygen-containing group at the ortho position (I) were important determinants for the antitumor activities.
Journal ArticleDOI
Use of anionic liposomes for the reduction of chronic doxorubicin-induced cardiotoxicity
Eric A. Forssen,Zoltán A. Tökés +1 more
TL;DR: It is concluded that anionic liposomes can function as efficacious carriers of doxorubicin and possess improved therapeutic action as reflected by their ability to reduce cardiac toxicity, overcome growth inhibition, and increase antileukemic activity.
Journal ArticleDOI
Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition.
TL;DR: In this paper, the authors investigated the biochemical changes that permit the dehiscence of the sinusoidal endothelial cells from the space of Disse and showed that matrix metalloproteinase inhibitors may be a therapeutically viable strategy for prevention.
Journal ArticleDOI
Matrix metalloproteinases in the neocortex and spinal cord of amyotrophic lateral sclerosis patients.
Giselle P. Lim,Jon R. Backstrom,Michael Cullen,Carol A. Miller,Roscoe Atkinson,Zoltán A. Tökés +5 more
TL;DR: The abnormally high amount of MMP‐9 and its possible release at the synapse may destroy the structural integrity of the surrounding matrix, thereby contributing to the pathogenesis of ALS.