Zongyi Hu

TL;DR: A genome-wide small interfering RNA (siRNA) screen using an infectious HCV cell culture system was completed and candidate genes found included known or previously identified factors, and also implicate many additional host cell proteins in HCV infection.

TL;DR: An association in vivo of HBX with the 26S proteasome complex is demonstrated by coimmunoprecipitation and colocalization upon sucrose gradient centrifugation and blocked the transactivation by HBX.

TL;DR: It is suggested that HCV-LP immunization inducesHCV-specific cellular immune responses that can control HCV challenge in the chimpanzee model.

TL;DR: The study suggests that ribavirin, acting by way of a novel innate mechanism, potentiates the anti‐HCV effect of IFN.

TL;DR: Chlorcyclizine HCl (CCZ), an over-the-counter drug for allergy symptoms, is identified and characterized as an anti-HCV drug in vitro and in vivo, and represents a promising candidate for drug repurposing and further development as an effective and accessible agent for treatment of HCV infection.