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Zoya A. Syzova

Bio: Zoya A. Syzova is an academic researcher from University of Kharkiv. The author has contributed to research in topics: Quenching (fluorescence) & Electron transfer. The author has an hindex of 3, co-authored 3 publications receiving 73 citations.

Papers
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Journal ArticleDOI
TL;DR: 2,6-bis(1H-benzimidazol-2-yl)pyridine (BBP), which is almost non-fluorescent in aqueous solutions, reveals a strong emission enhancement in a hydrophobic environment of a phospholipid bilayer, making it interesting for fluorescence probing of water content in a lipid membrane.

40 citations

Journal ArticleDOI
TL;DR: In this paper, the 2-(benzimidazol-2-yl) derivative of 3-hydroxychromone was synthesized and studied by X-ray structure analysis, 1H NMR and fluorescence spectroscopy.

22 citations

Journal ArticleDOI
TL;DR: Bichromophoric 3-diethylamino-7-phenyl-7H-benzo-[4,5]-imidazo-[1,2-c]-chromeno-[3,2e]-pyrimidines were synthesized by the condensation of 7-diagramnino-3-(2-benzimidazolyl)-iminochromene with several aromatic aldehydes as discussed by the authors.
Abstract: Bichromophoric 3-diethylamino-7-phenyl-7H-benzo-[4,5]-imidazo-[1,2-c]-chromeno-[3,2-e]-pyrimidines were synthesized by the condensation of 7-diethylamino-3-(2-benzimidazolyl)-iminochromene with several aromatic aldehydes. Fluorescence properties of these compounds were studied in solvents of various polarity and acidity. The excited state intramolecular electron transfer was shown as the reason for the fluorescence quenching of the studied dyes with electron donor substituents in the minor chromophoric moiety. Prospects for the usage of these compounds as fluorescence probes sensitive to polarity and pH of their surrounding were elucidated.

16 citations


Cited by
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Journal ArticleDOI
TL;DR: A selection of methods for performing enhanced sampling in molecular dynamics simulations are reviewed and methods based on collective variable biasing are considered.
Abstract: We review a selection of methods for performing enhanced sampling in molecular dynamics simulations. We consider methods based on collective variable biasing and on tempering, and offer both historical and contemporary perspectives. In collective-variable biasing, we first discuss methods stemming from thermodynamic integration that use mean force biasing, including the adaptive biasing force algorithm and temperature acceleration. We then turn to methods that use bias potentials, including umbrella sampling and metadynamics. We next consider parallel tempering and replica-exchange methods. We conclude with a brief presentation of some combination methods.

340 citations

Journal ArticleDOI
27 Dec 2013-Entropy
TL;DR: In this article, a selection of methods for performing enhanced sampling in molecular dynamics simulations is presented, based on collective variable biasing (CVB) and collective variable sampling (CVB).
Abstract: We review a selection of methods for performing enhanced sampling in 1 molecular dynamics simulations. We consider methods based on collective variable biasing 2

296 citations

Journal ArticleDOI
TL;DR: A new family of coumarin-based pH indicators was synthesized, sensitive to pH in either weakly acidic or weakly basic solution, which possess moderate to high brightness, excellent photostability and compatibility with light-emitting diodes.
Abstract: A new family of coumarin-based pH indicators was synthesized. They are sensitive to pH in either weakly acidic or weakly basic solution. The indicators possess moderate to high brightness, excellent photostability and compatibility with light-emitting diodes. The indicators were covalently immobilized on the surface of amino-modified polymer microbeads which in turn were incorporated into a hydrogel matrix to obtain novel pH-sensitive materials. When a mixture of two different microbeads is used, the membranes are capable of optical pH sensing over a very wide range comparable to the dynamic range of the glass electrode (pH 1-11).

97 citations

Journal ArticleDOI
TL;DR: This work judiciously designed an organic white light-emitting dye and used it as a robust platform to engineer a new fluorescent sensor for monitoring H2S with turn-on fluorescence signals in blue, green, and red emission channels in both solution and living cells.

78 citations

Journal ArticleDOI
TL;DR: This article reviews the application of molecular dynamics to the study of fluorescent membrane probes, focusing on recent work with complex design fluorophores and ordered bilayer systems.
Abstract: Due to their sensitivity and versatility, the use of fluorescence techniques in membrane biophysics is widespread. Because membrane lipids are non-fluorescent, extrinsic membrane probes are widely used. However, the behaviour of these probes when inserted in the bilayer is often poorly understood, and it can be hard to distinguish between legitimate membrane properties and perturbation resulting from probe incorporation. Atomistic molecular dynamics simulations present a convenient way to address these issues and have been increasingly used in recent years in this context. This article reviews the application of molecular dynamics to the study of fluorescent membrane probes, focusing on recent work with complex design fluorophores and ordered bilayer systems.

59 citations