Showing papers presented at "International Conference on Bioinformatics in 2000"
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01 Dec 2000
TL;DR: It is demonstrated that handling unordered categorical covariates with numerous levels and accompanying interactions can be done effectively using classification trees and recently devised bump‐hunting methods.
Abstract: We illustrate data analytic concerns that arise in the context of relating “genotype”, as represented by amino acid sequence, to phenotypes (outcomes). The present application examines whether peptides that bind to a particular major histocompatibility complex (MHC) class I molecule have characteristic amino acid sequences. However, the concerns identified and addressed are considerably more general. It is recognized that simple rules for predicting binding based solely on preferences for specific amino acids in certain (anchor) positions of the peptide’s amino acid sequence are generally inadequate and that binding is potentially influenced by all sequence positions as well as between-position interactions. The desire to elucidate these more complex prediction rules has spawned various modeling attempts, the shortcomings of which provide motivation for the methods adopted here. Because of (i) this need to model between-position interactions, (ii) amino acids constituting a highly (20) multilevel unordered categorical covariate, and (iii) there frequently being numerous such covariates (i.e. positions) comprising the sequence standard regression/classification techniques are problematic due to the proliferation of indicator variables required for encoding the sequence position covariates and attendant interactions. These difficulties have led to analyses based on (continuous) properties (e.g. molecular weights) of the amino acids. However, there is potential information loss in such an approach if the properties used are incomplete and/or do not capture the mechanism underlying association with the phenotype. Here we demonstrate that handling unordered categorical covariates with numerous levels and accompanying interactions can be done effectively using classification trees and recently devised bump-hunting methods. We further tackle the question of whether observed associations are attributable to amino acid properties as well as addressing the assessment and implications of between-position covariation.
60 citations
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01 Jan 2000
36 citations
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[...]
01 Jan 2000
TL;DR: Aprender los fundamentos de la gestión de proyectos Aprender cómo se gestionan proyreectos de localización, e.g., con traducción automática.
Abstract: Aprender los fundamentos de la gestión de proyectos Aprender cómo se gestionan proyectos de localización Aprender cómo se gestionan proyectos con traducción automática Aprender a aplicar técnicas de SEO (Search Engine Optimisation) y SEM (Search Engine Management) Aprender técnicas avanzadas de hojas de cálculo Aprender cuestiones relativas a la fiscalidad para traductores y a la creación de empresas Conocer estrategias de inserción laboral Aprender estrategias para trabajar como traductor autónomo
27 citations
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01 Jan 2000
5 citations
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01 Jan 2000
4 citations
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01 Mar 2000
TL;DR: CAD systems for PC platforms are studied, analyzing its basic functionalities and fundamental characteristics, and mid-range 3D applications, specifically in mechanical CAD environements are focused on.
Abstract: At present, thanks to the increase of hardware performance, there is
a wide range of CAD systems for personal computers, from small 2D
applications to sophisticated and complete 3D systems. CAD systems
for PC platforms are studied in this report, analyzing its basic
functionalities and fundamental characteristics. We focus on
mid-range 3D applications, specifically in mechanical CAD
environements. Actual CAD systems are classified according to
different criteria, and mid-range systems are characterized. The
design methodology is described, distinguishing between the
classical approach and the parametric feature-based design. The
structure of these systems is studied, briefly describing the
typical modules they are made of. Problems with standard CAD file
formats are discussed, and the specific interface widgets are
presented. Finally, the conclusions are presented. Besides
bibliographic references, a list of web sites concerning CAD systems
is also included.