Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science.
Emily A. Holmes,Emily A. Holmes,Rory C. O'Connor,V. Hugh Perry,Irene Tracey,Simon Wessely,Louise Arseneault,Clive Ballard,Helen Christensen,Roxane Cohen Silver,Ian P. Everall,Tamsin Ford,Ann John,Thomas Kabir,Kate King,Ira Madan,Susan Michie,Andrew K. Przybylski,Roz Shafran,Angela Sweeney,Carol M. Worthman,Lucy Yardley,Katherine Cowan,Claire Cope,Matthew Hotopf,Edward T. Bullmore +25 more
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TLDR
There is an urgent need for research to address how mental health consequences for vulnerable groups can be mitigated under pandemic conditions, and on the impact of repeated media consumption and health messaging around COVID-19.About:
This article is published in The Lancet Psychiatry.The article was published on 2020-04-15 and is currently open access. It has received 3909 citations till now. The article focuses on the topics: Mental health & Psychological intervention.read more
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Prevalence of depression, anxiety, and insomnia among healthcare workers during the COVID-19 pandemic: A systematic review and meta-analysis.
Sofia Pappa,Vasiliki Ntella,Timoleon Giannakas,Vassilis G. Giannakoulis,Eleni Papoutsi,Paraskevi Katsaounou +5 more
TL;DR: Early evidence suggests that a considerable proportion of HCWs experience mood and sleep disturbances during this outbreak, stressing the need to establish ways to mitigate mental health risks and adjust interventions under pandemic conditions.
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Prevalence of stress, anxiety, depression among the general population during the COVID-19 pandemic: a systematic review and meta-analysis.
Nader Salari,Amin Hosseinian-Far,Rostam Jalali,Aliakbar Vaisi-Raygani,Shna Rasoulpoor,Masoud Mohammadi,Shabnam Rasoulpoor,Behnam Khaledi-Paveh +7 more
TL;DR: This systematic review and meta-analysis of existing research works and findings in relation to the prevalence of stress, anxiety and depression in the general population during the COVID-19 pandemic found that it is essential to preserve the mental health of individuals and to develop psychological interventions that can improve themental health of vulnerable groups during the pandemic.
Journal ArticleDOI
Mental health before and during the COVID-19 pandemic: a longitudinal probability sample survey of the UK population.
Matthias Pierce,Holly Hope,Tamsin Ford,Stephani L. Hatch,Matthew Hotopf,Ann John,Evangelos Kontopantelis,Roger T. Webb,Simon Wessely,Sally McManus,Kathryn M. Abel +10 more
TL;DR: Mental health in the UK had deteriorated compared with pre-COVID-19 trends by late April, 2020, and policies emphasising the needs of women, young people and those with preschool aged children are likely to play an important part in preventing future mental illness.
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Effects of COVID-19 on College Students' Mental Health in the United States: Interview Survey Study.
TL;DR: Due to the long-lasting pandemic situation and onerous measures such as lockdown and stay-at-home orders, the COVID-19 pandemic brings negative impacts on higher education.
References
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Stress, appraisal, and coping
Richard S. Lazarus,Susan Folkman +1 more
TL;DR: In this paper, the authors present a detailed theory of psychological stress, building on the concepts of cognitive appraisal and coping, which have become major themes of theory and investigation in psychology.
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann,Hannah Kleine-Weber,Simon Schroeder,Nadine Krüger,Tanja Herrler,Sandra Erichsen,Tobias S. Schiergens,Georg Herrler,Nai Huei Wu,Andreas Nitsche,Marcel A. Müller,Christian Drosten,Christian Drosten,Stefan Pöhlmann +13 more
TL;DR: It is demonstrated that SARS-CoV-2 uses the SARS -CoV receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming, and it is shown that the sera from convalescent SARS patients cross-neutralized Sars-2-S-driven entry.
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The psychological impact of quarantine and how to reduce it: rapid review of the evidence.
Samantha K Brooks,Rebecca K. Webster,Louise E. Smith,Lisa Woodland,Simon Wessely,Neil Greenberg,Gideon James Rubin +6 more
TL;DR: A review of the psychological impact of quarantine using three electronic databases is presented in this article, where the authors report negative psychological effects including post-traumatic stress symptoms, confusion, and anger.
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Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Roujian Lu,Xiang Zhao,Juan Li,Peihua Niu,Bo Yang,Honglong Wu,Wenling Wang,Hao Song,Baoying Huang,Na Zhu,Yuhai Bi,Xuejun Ma,Faxian Zhan,Liang Wang,Tao Hu,Hong Zhou,Zhenhong Hu,Weimin Zhou,Li Zhao,Jing Chen,Yao Meng,Ji Wang,Yang Lin,Jianying Yuan,Zhihao Xie,Jinmin Ma,William J. Liu,Dayan Wang,Wenbo Xu,Edward C. Holmes,George F. Gao,George F. Gao,Guizhen Wu,Weijun Chen,Weifeng Shi,Wenjie Tan,Wenjie Tan +36 more
TL;DR: The phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans.
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Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.