Institution
Aalborg Hospital
Healthcare•Aalborg, Nordjylland, Denmark•
About: Aalborg Hospital is a healthcare organization based out in Aalborg, Nordjylland, Denmark. It is known for research contribution in the topics: Population & Cohort study. The organization has 1992 authors who have published 2431 publications receiving 86851 citations.
Topics: Population, Cohort study, Polyunsaturated fatty acid, Pregnancy, Cancer
Papers published on a yearly basis
Papers
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TL;DR: Irbesartan is renoprotective independently of its blood-pressure-lowering effect in patients with type 2 diabetes and microalbuminuria, and serious adverse events were less frequent among the patients treated with the drug.
Abstract: Background Microalbuminuria and hypertension are risk factors for diabetic nephropathy. Blockade of the renin–angiotensin system slows the progression to diabetic nephropathy in patients with type 1 diabetes, but similar data are lacking for hypertensive patients with type 2 diabetes. We evaluated the renoprotective effect of the angiotensin-II–receptor antagonist irbesartan in hypertensive patients with type 2 diabetes and microalbuminuria. Methods A total of 590 hypertensive patients with type 2 diabetes and microalbuminuria were enrolled in this multinational, randomized, double-blind, placebo-controlled study of irbesartan, at a dose of either 150 mg daily or 300 mg daily, and were followed for two years. The primary outcome was the time to the onset of diabetic nephropathy, defined by persistent albuminuria in overnight specimens, with a urinary albumin excretion rate that was greater than 200 μg per minute and at least 30 percent higher than the base-line level. Results The base-line characteristics...
2,853 citations
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TL;DR: Unlike arachidonic acid, eicosapentaenoic acid (C20:5omega-3, E.P.A.) does not induce platelet aggregation in human platelet-rich plasma (P.R.X.A.P.), probably because of the formation of thromboxane A3 (T.G.I3) which does not have platelet aggregating properties.
1,632 citations
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TL;DR: In this trial, prophylactic ICD implantation in patients with symptomatic systolic heart failure not caused by coronary artery disease was not associated with a significantly lower long-term rate of death from any cause than was usual clinical care.
Abstract: BackgroundThe benefit of an implantable cardioverter–defibrillator (ICD) in patients with symptomatic systolic heart failure caused by coronary artery disease has been well documented. However, the evidence for a benefit of prophylactic ICDs in patients with systolic heart failure that is not due to coronary artery disease has been based primarily on subgroup analyses. The management of heart failure has improved since the landmark ICD trials, and many patients now receive cardiac resynchronization therapy (CRT). MethodsIn a randomized, controlled trial, 556 patients with symptomatic systolic heart failure (left ventricular ejection fraction, ≤35%) not caused by coronary artery disease were assigned to receive an ICD, and 560 patients were assigned to receive usual clinical care (control group). In both groups, 58% of the patients received CRT. The primary outcome of the trial was death from any cause. The secondary outcomes were sudden cardiac death and cardiovascular death. ResultsAfter a median follow-...
1,239 citations
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TL;DR: Partial dietary substitution of arachidonic acid by eicosapentaenoic acid may reduce the incidence of thrombotic disorders, including myocardial infarction, among Eskimos.
938 citations
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TL;DR: OA patients showed a significant facilitation of temporal summation from both the knee and TA and had significantly less DNIC as compared with controls, and the importance of central sensitization as an important manifestation in knee OA is highlighted.
Abstract: Pain is the dominant symptom in osteoarthritis (OA) and sensitization may contribute to the pain severity. This study investigated the role of sensitization in patients with painful knee OA by measuring (1) pressure pain thresholds (PPTs); (2) spreading sensitization; (3) temporal summation to repeated pressure pain stimulation; (4) pain responses after intramuscular hypertonic saline; and (5) pressure pain modulation by heterotopic descending noxious inhibitory control (DNIC). Forty-eight patients with different degrees of knee OA and twenty-four age- and sex-matched control subjects participated. The patients were separated into strong/severe (VAS>or=6) and mild/moderate pain (VAS<6) groups. PPTs were measured from the peripatellar region, tibialis anterior (TA) and extensor carpi radialis longus muscles before, during and after DNIC. Temporal summation to pressure was measured at the most painful site in the peripatellar region and over TA. Patients with severely painful OA pain have significantly lower PPT than controls. For all locations (knee, leg, and arm) significantly negative correlations between VAS and PPT were found (more pain, more sensitization). OA patients showed a significant facilitation of temporal summation from both the knee and TA and had significantly less DNIC as compared with controls. No correlations were found between standard radiological findings and clinical/experimental pain parameters. However, patients with lesions in the lateral tibiofemoral knee compartment had higher pain ratings compared with those with intercondylar and medial lesions. This study highlights the importance of central sensitization as an important manifestation in knee OA.
833 citations
Authors
Showing all 2008 results
Name | H-index | Papers | Citations |
---|---|---|---|
Kim Overvad | 139 | 1196 | 86018 |
Preben Bo Mortensen | 121 | 650 | 60052 |
Henrik Toft Sørensen | 120 | 1591 | 74943 |
Lars Arendt-Nielsen | 118 | 1410 | 59474 |
Christian Torp-Pedersen | 110 | 1164 | 58121 |
Henrik Clausen | 109 | 520 | 49820 |
Søren Nielsen | 105 | 806 | 45995 |
Hans-Christoph Steinhausen | 80 | 508 | 30308 |
Peter Laurberg | 78 | 388 | 23140 |
Lawrence F. Marshall | 75 | 166 | 27072 |
Leif Thuesen | 74 | 317 | 23208 |
Henrik Nielsen | 70 | 277 | 63053 |
Peter Vestergaard | 70 | 405 | 17318 |
Lars Pedersen | 70 | 418 | 22420 |
Yuan-Cheng Fung | 69 | 218 | 30827 |