Showing papers by "Aarhus University published in 1968"
TL;DR: An up-to-date, critical assessment of psychiatric lithium therapy and prophylactic action against endogenous affective disorder, including manic-depressive disorder and recurrent endogenous depressions is presented.
461 citations
235 citations
151 citations
TL;DR: Repeated measurements of motor conduction velocity in 14 primarily untreated diabetics showed a clear improvement in nerve-function during insulin treatment, and similar results could not be produced by measuring the threshold for vibration sense.
Abstract: Repeated measurements of motor conduction velocity in 14 primarily untreated diabetics showed a clear improvement in nerve-function during insulin treatment — Similar results could not he produced by measuring the threshold for vibration sense
149 citations
TL;DR: Apart from its effect on sugar permeability, Li + seems to induce a progressive decrease in glucose catabolism, and it is possible that this is the result of a gradual reduction in the energy demand for active cation transport.
140 citations
TL;DR: The finding suggests that the enzyme is not primarily under the control of the adrenals, and might indicate an effect of sodium on activity levels of the (Na+ + K+-activated enzyme in rat kidney).
121 citations
TL;DR: In this paper, the moment directions of the electronic transitions of fluoranthene in the range 3700 A - 2100 A were found by means of the stretched film technique, and the moment direction of the transition was determined in terms of the length of the film.
109 citations
TL;DR: Phytohaemagglutinin induced early changes in the catabolism of glucose by normal human lymphocytes suspended in a bicarbonate buffer but was almost completely inhibited by puromycin, which abolished phytohaamagglUTinin-induced stimulation of glycolysis.
Abstract: 1. Phytohaemagglutinin induced early changes in the catabolism of glucose by normal human lymphocytes suspended in a bicarbonate buffer. During 4hr. incubation glucose utilization was almost doubled. 2. The rates of several reactions in the metabolism of glucose were estimated. Total pyruvate formation, lactate production and fatty acid synthesis were stimulated to the same degree as was glucose utilization. The pentose cycle and the glycogen synthesis were also stimulated but less than was glucose utilization. The pentose cycle was found to account for 1.4% and 0.9% of the total glucose utilization without and with phytohaemagglutinin respectively. In these cells rates of triose phosphate iso-merization were at least six to seven times the rate of glucose phosphorylation. On an average 55-60% of the total carbon dioxide evolved was derived from decarboxylation of pyruvate, 25-30% from the tricarboxylic acid cycle and about 15% from the pentose cycle. Observed ratios of (14)C specific yields in glycogen from [1-(14)C]- and [6-(14)C]-glucose could possibly be explained by assuming the existence of two separate glucose 6-phosphate pools. 3. During 4hr. incubation in bicarbonate buffer (14)C from [U-(14)C]serine was incorporated into perchloric acid-insoluble material. This incorporation was stimulated by phytohaemagglutinin but was almost completely inhibited by puromycin. Puromycin also abolished phytohaemagglutinin-induced stimulation of glycolysis.
109 citations
TL;DR: A characteristic pattern was observed, consisting of the development of coarse, irregular dots along the pupillary border, showing confluence and culminating in a glow which lasted for the entire period of observation (50 sec), interpreted as the expression of an abnormal capillary permeability of the vascular arcades of the annulus minor.
Abstract: Fluorescence angiographie studies have been carried out on a series of non-diabetics, young recent diabetics and long-term diabetic patients with retinopathy — The time of appearance was 9–21 sec, the arterial phase lasted 3–5 sec, not significantly different in the three groups of patients — In the non-diabetics and the young patients with recent juvenile diabetes, tiny fluorescent dots along the pupillary seam were observed for a short interval of time — In long-term diabetic patients a characteristic pattern was observed, consisting of the development of coarse, irregular dots along the pupillary border, showing confluence and culminating in a glow which lasted for the entire period of observation (50 sec) This pattern is interpreted as the expression of an abnormal capillary permeability of the vascular arcades of the annulus minor — The abnormal pattern of confluence and glow was observed in long-term diabetic patients before the development of visible rubeosis iridis — The rubeosis vessels filled after the appearance of the confluent dots and emptied into the veins
54 citations
TL;DR: It is concluded that Na + is not essential for the uptake of glucose in diaphragm muscle and hyperosmolarity, whether induced by the addition of NaCl, LiCl, mannitol or choline chloride, gave an increase in glucose uptake.
52 citations
TL;DR: The mass spectra of 22 benzimidazoles are reported and discussed in this paper, where the basic fragmentation patterns have been substantiated by deuterium labelling, exact mass measurements and appropriate metastable ions.
TL;DR: In this paper, the effect of different solvents on the chelated enethiol system is described and discussed, and the thermochromism exhibited by the β-thioketothiolesters has been studied by NMR and is attributed to a shift in the thioketo-enethiol equilibrium.
TL;DR: In this paper, a new expression for the square of the transition moment appearing in the intensity formulas for vibration-rotational transitions of symmetric top molecules was derived, in agreement with the classical expressions, but has the advantage in one simple formula to cover all cases of infrared and Raman bands.
TL;DR: The mass spectra of a series of nitrones are reported and discussed in this paper, where the majority of fragment ions owe their genesis to skeletal-reorganization of the molecular ion.
TL;DR: Determinations of the base composition in the seven human T strains are reported, and knowledge of the DNA base composition might be a valuable approach to a rational classification of these organisms.
Abstract: THE T strain mycoplasmas constitute a unique group with some properties distinct from those of the classical mycoplasmas1,2. Recently it has become possible to separate seven serologically different strains within the group of the human T strains3. The subcommittee on the taxonomy of mycoplasmatales4 has not yet finished its discussion of the taxonomy of these mycoplasmas, but awaits further experimental data. Knowledge of the DNA base composition might be a valuable approach to a rational classification of these organisms, and we report here determinations of the base composition in the seven human T strains.
TL;DR: In this article, the synthesis and properties of α-thioacyllactones and their absolute configurations determined by NMR spectroscopy are discussed and the influence of different solvents on chemical shifts and coupling constants are also described and discussed.
TL;DR: In this article, it was proposed that these salts result from an intramolecular reaction of initially formed alkylation products, in which case the initial alkyl product undergoes an intramerolecular condensation with subsequent hydrogen chloride elimination.
TL;DR: In this article, Implanted dopant ions are used to form the resistive layer in position sensitive p-n junction particle detectors and position resolution of 0.2 mm fwhm and linearity of ± 0.3 mm are obtained.
TL;DR: In this article, an examination of five strains of Dahlia coccinea for polyacetylenes reveals a close chemical similarity between the five morphological types, especially in the tubers.
TL;DR: The advantages and problems associated with the use of ion implantation for the fabrication of position-sensitive particle detectors are discussed in this article, where it is found that it is desirable to use equal pulse shaping in the energy and the position signal measuring systems.
Abstract: The advantages and problems associated with the use of ion implantation for the fabrication of position-sensitive particle detectors are discussed. Analysis of the noise and pulse risetime properties of such devices shows the desirability of using a high sheet resistance in the distributing resistive layer for optimum position resolution while restricting the RC of the detector to values approximately equal to the clipping times used in the measuring circuits in order to obtain good position linearity. From both detector noise and pulse rise-time considerations it is found desirable to use equal pulse shaping in the energy and the position signal measuring systems. Detectors were made by implantation of 60 keV boron and phosphorus ions into 4000 ohm-cm n-type silicon. Representative results are shown for a 4×32 mm2 one dimensional detector which shows integral and differential position nonlinearity of less than one percent and position resolution of less than 0.2 mm. Extension to one dimensional detectors up to 50 mm and to 10×10mm two dimensional detectors is discussed.
TL;DR: It is suggested, that the activating effect of Mg2+ on the D to I transformation is due to an activation of an endogenous ATP-ase and adenylate kinase, and that diabetic leucocytes possess transferase-D phosphatase activity in contrast to normal cells.
Abstract: 1. In normal leucocytes, glycogen-transferase was only found in the glucose-6-phosphate dependent D-form. An increase in activity was observed within 30 min after glucose feeding, and is assumed to be mediated through the action of released insulin. A late secondary increase in activity occurred simultaneously with an increase in serum growth hormone. — 2. In most diabetic leucocytes, glycogen-transferase was found in both the I- (independent of glucose-6-phosphate) and D-form. The I+D activity was low in uncontrolled diabetes and increased in response to insulin treatment. The I-activity was low immediately upon isolation of the leucocytes, but increased during incubation of the enzyme, especially in the presence of Mg2+; indicating that diabetic leucocytes possess transferase-D phosphatase activity in contrast to normal cells. The D to I transformation of the enzyme was greatly increased by insulin treatment. — 3. K
m
for UDPG and K
a
for glucose-6-phosphate did not vary between normal and diabetic leucocytes. — 4. The D to I interconversion of the incubated enzyme from diabetic cells was found to depend on the concentration of ATP and ADP in the incubation medium. It is suggested, that the activating effect of Mg2+ on the D to I transformation is due to an activation of an endogenous ATP-ase and adenylate kinase.
TL;DR: In this paper, the 1183 keV transition depopulating the 2+ beta-vibrational state in 178Hf was found to be E2 + M1 with (17 ± 10)% E2.
TL;DR: The electron capture of 57 h 153Tb has been studied with isotope-separated sources by means of direct and coincidence spectrometry with a six-gap beta-ray spectrometer and Ge(Li) gamma-ray detectors.
TL;DR: In this paper, the electron-capture decay of 10.2 d 188 Pt has been investigated with Ge(Li), Si(Li) and NaI(Tl) detectors, a six-gap magnetic spectrometer and coincidence techniques.
TL;DR: In this paper, the temperature dependence of the perturbed angular correlation of the 198-110 keV γ cascade in 169 Tm implanted in iron foil is consistent with a time-dependent magnetic interaction with a relaxation time constant τ S = 2 ps.
TL;DR: In this article, it is shown from basic thermodynamics that temperature and entropy are invariant in special relativity, and that it is preferable to use only quantities like energy and entropy, for which conservation laws apply.