Academia Sinica

About: Academia Sinica is a facility organization based out in Taipei, Taiwan. It is known for research contribution in the topics: Population & Galaxy. The organization has 52086 authors who have published 65998 publications receiving 1728114 citations. The organization is also known as: Central Research Academy.

The opportunistic marine pathogen Vibrio parahaemolyticus becomes virulent by acquiring a plasmid that expresses a deadly toxin

Abstract: Acute hepatopancreatic necrosis disease (AHPND) is a severe, newly emergent penaeid shrimp disease caused by Vibrio parahaemolyticus that has already led to tremendous losses in the cultured shrimp industry. Until now, its disease-causing mechanism has remained unclear. Here we show that an AHPND-causing strain of V. parahaemolyticus contains a 70-kbp plasmid (pVA1) with a postsegregational killing system, and that the ability to cause disease is abolished by the natural absence or experimental deletion of the plasmid-encoded homologs of the Photorhabdus insect-related (Pir) toxins PirA and PirB. We determined the crystal structure of the V. parahaemolyticus PirA and PirB (PirA(vp) and PirB(vp)) proteins and found that the overall structural topology of PirA(vp)/PirB(vp) is very similar to that of the Bacillus Cry insecticidal toxin-like proteins, despite the low sequence identity (<10%). This structural similarity suggests that the putative PirAB(vp) heterodimer might emulate the functional domains of the Cry protein, and in particular its pore-forming activity. The gene organization of pVA1 further suggested that pirAB(vp) may be lost or acquired by horizontal gene transfer via transposition or homologous recombination.

Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function

Abstract: Reduced glomerular filtration rate defines chronic kidney disease and is associated with cardiovascular and all-cause mortality. We conducted a meta-analysis of genome-wide association studies for estimated glomerular filtration rate (eGFR), combining data across 133,413 individuals with replication in up to 42,166 individuals. We identify 24 new and confirm 29 previously identified loci. Of these 53 loci, 19 associate with eGFR among individuals with diabetes. Using bioinformatics, we show that identified genes at eGFR loci are enriched for expression in kidney tissues and in pathways relevant for kidney development and transmembrane transporter activity, kidney structure, and regulation of glucose metabolism. Chromatin state mapping and DNase I hypersensitivity analyses across adult tissues demonstrate preferential mapping of associated variants to regulatory regions in kidney but not extra-renal tissues. These findings suggest that genetic determinants of eGFR are mediated largely through direct effects within the kidney and highlight important cell types and biological pathways.

The Heilongjiang Group: A Jurassic accretionary complex in the Jiamusi Massif at the western Pacific margin of northeastern China

Abstract: The tectonic setting of the Eastern Asian continental margin in the Jurassic is highly controversial. In the current study, we have selected the Heilongjiang complex located at the western margin of the Jiamusi Massif in northeastern China for geochronological investigation to address this issue. Field and petrographic investigations indicate that the Heilongjiang complex is composed predominately of granitic gneiss, marble, mafic-ultramafic rocks, blueschist, greenschist, quartzite, muscovite-albite schist and two-mica schist that were tectonically interleaved, indicating they represent a melange. The marble, two-mica schist and granitic gneiss were most probably derived from the Mashan complex, a high-grade gneiss complex in the Jiamusi Massif with which the Heilongjiang Group is intimately associated. The ultramafic rocks, blueschist, greenschist and quartzite (chert) are similar to components in ophiolite. The sensitive high mass-resolution ion microprobe U-Pb zircon age of 265 ± 4 Ma for the granitic gneiss indicates that the protolith granite was emplaced coevally with Permian batholiths in the Jiamusi Massif. 40Ar/39Ar dating of biotite and phengite from the granitic gneiss and mica schist yields a late Early Jurassic metamorphic age between 184 and 174 Ma. Early components of the Jiamusi Massif, including the Mashan complex, probably formed part of an exotic block from Gondwana, affected by late Pan-African orogenesis, and collided with the Asian continental margin during the Early Jurassic. Subduction of oceanic crust between the Jiamusi block and the eastern part of the Central Asian Orogenic Belt resulted in the formation of a huge volume of Jurassic granites in the Zhangguangcai Range. Consequently, the collision of the Jiamusi Massif with the Central Asian Orogenic Belt to the west can be considered as the result of circum-Pacific accretion, unrelated to the Central Asian Orogenic Belt. The widespread development of Jurassic accretionary complexes along the Asian continental margin supports such an interpretation.

The Geometry of grasping

Abstract: A form closure (or complete restraint) of a solid object is a finite set of wrenches (force-moment combinations) applied on the object, with the property that any other wrench acting on the object can be balanced by a positive combination of the original ones. Intuitively, form closure is a way of defining the notion of a "firm grip" of the object (when friction is not taken into account). It has been pointed out by Reuleaux (1875) and Somoff (1897), and more recently by Lakshmin arayana (1978), that the form closure of a two-dimensional object requires at least four wrenches, and that form closure of a three-dimensional object requires at least seven wrenches. It was also conjectured that these numbers can be achieved by wrenches realizable as forces normal to the surface of the object (such wrenches are called fingers). In this paper we prove this conjecture. In particular we show that form closure of any two-dimensional bounded object with piecewise smooth boundary (except a circle) can be achieved by ...