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Institution

Academia Sinica

FacilityTaipei, Taiwan
About: Academia Sinica is a facility organization based out in Taipei, Taiwan. It is known for research contribution in the topics: Population & Galaxy. The organization has 52086 authors who have published 65998 publications receiving 1728114 citations. The organization is also known as: Central Research Academy.


Papers
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Journal ArticleDOI
TL;DR: The results support the notion that the metastatic behavior of lung cancer cells can be characterized with this in vitro system, and that the properties of these progressively invasive cancer Cells can be clonally studied.
Abstract: To better understand the mechanism(s) underlying lung cancer invasion and metastasis, a Transwell invasion chamber was used to select progressively more invasive cancer cell populations from a clonal cell line of human lung adenocarcinoma, CL1. Five sublines with progressive invasiveness, designated CL1-1, CL1-2, CL1-3, CL1-4, and CL1-5, were obtained through this in vitro selection process. Their invasive abilities through basement membrane matrix showed a 4- to 6-fold increase over that of the parental cells. Moreover, the sublines manifested an increase in their colony-forming ability on soft agar, tumorigenicity, and metastatic potency in severe combined immunodeficiency (SCID) mice. Examining the phenotypes of the cell lines revealed increased expression of 92 kD gelatinase and an increase in the cell population stained with anti-keratin-8 and -18 antibodies. Clonal isolation of anti-keratin-18-antibody-positive and -negative cell populations demonstrated a correlated enhancement of the invasiveness of these cells and their expression of keratin-18. These results support the notion that the metastatic behavior of lung cancer cells can be characterized with this in vitro system, and that the properties of these progressively invasive cancer cells can be clonally studied.

405 citations

Journal ArticleDOI
TL;DR: Inhibition of Trichoderma reesei cellulase by sugars, δ‐gluconolactone, and cellobiose and solvents and Solvents was studied using cellulose azure.
Abstract: Inhibition of Trichoderma reesei cellulase by sugars (glucose, delta-gluconolactone, and cellobiose) and solvents (ethanol, butanol, and acetone) was studied using cellulose azure. Glucose, cellobiose, ethanol, and butanol were noncompetitive inhibitors, delta-gluconolactone was a mixed inhibitor, and acetone was a noncompetitive activator. Converting cellobiose to glucose reduces the effective inhibitor binding constant by 6 times and converting cellobiose to ethanol reduces it by 16 times.

405 citations

Journal ArticleDOI
TL;DR: In this paper, the cosmological constraints from 2D weak gravitational lensing by the large-scale structure in the Canada-France-Hawaii Telescope Lensing Survey (CFHTLenS) are presented.
Abstract: We present cosmological constraints from 2D weak gravitational lensing by the large-scale structure in the Canada–France–Hawaii Telescope Lensing Survey (CFHTLenS) which spans 154 deg^2 in five optical bands. Using accurate photometric redshifts and measured shapes for 4.2 million galaxies between redshifts of 0.2 and 1.3, we compute the 2D cosmic shear correlation function over angular scales ranging between 0.8 and 350 arcmin. Using non-linear models of the dark-matter power spectrum, we constrain cosmological parameters by exploring the parameter space with Population Monte Carlo sampling. The best constraints from lensing alone are obtained for the small-scale density-fluctuations amplitude σ_8 scaled with the total matter density Ωm. For a flat Λcold dark matter (ΛCDM) model we obtain σ_8(Ω_m/0.27)0.6 = 0.79 ± 0.03. We combine the CFHTLenS data with 7-year Wilkinson Microwave Anisotropy Probe (WMAP7), baryonic acoustic oscillations (BAO): SDSS-III (BOSS) and a Hubble Space Telescope distance-ladder prior on the Hubble constant to get joint constraints. For a flat ΛCDM model, we find Ω_m = 0.283 ± 0.010 and σ_8 = 0.813 ± 0.014. In the case of a curved wCDM universe, we obtain Ω_m = 0.27 ± 0.03, σ_8 = 0.83 ± 0.04, w0 = −1.10 ± 0.15 and Ω_K = 0.006^(+0.006)_(− 0.004). We calculate the Bayesian evidence to compare flat and curved ΛCDM and dark-energy CDM models. From the combination of all four probes, we find models with curvature to be at moderately disfavoured with respect to the flat case. A simple dark-energy model is indistinguishable from ΛCDM. Our results therefore do not necessitate any deviations from the standard cosmological model.

405 citations

Journal ArticleDOI
TL;DR: In this paper, the authors used spin-resolved photoemission spectroscopy with p-polarized light in topological insulator Bi2Se3 thin films.
Abstract: Understanding the spin-texture behaviour of boundary modes in ultrathin topological insulator films is critically essential for the design and fabrication of functional nanodevices. Here, by using spin-resolved photoemission spectroscopy with p-polarized light in topological insulator Bi2Se3 thin films, we report tunnelling-dependent evolution of spin configuration in topological insulator thin films across the metal-to-insulator transition. We report a systematic binding energy- and wavevector-dependent spin polarization for the topological surface electrons in the ultrathin gapped-Dirac-cone limit. The polarization decreases significantly with enhanced tunnelling realized systematically in thin insulating films, whereas magnitude of the polarization saturates to the bulk limit faster at larger wavevectors in thicker metallic films. We present a theoretical model that captures this delicate relationship between quantum tunnelling and Fermi surface spin polarization. Our high-resolution spin-based spectroscopic results suggest that the polarization current can be tuned to zero in thin insulating films forming the basis for a future spin-switch nanodevice.

405 citations

Journal ArticleDOI
TL;DR: A SARS-CoV RNP model that conforms to existing data and bears resemblance to the existing RNP structures of RNA viruses is proposed, highlighting the critical role of modular organization and intrinsic disorder of the N protein in the formation and functions of the dynamic RNP capsid in RNA viruses.

404 citations


Authors

Showing all 52129 results

NameH-indexPapersCitations
Yi Chen2174342293080
Jing Wang1844046202769
Jie Zhang1784857221720
Hyun-Chul Kim1764076183227
Yang Yang1642704144071
Yuh Nung Jan16246074818
Jongmin Lee1502257134772
Hui-Ming Cheng147880111921
Teruki Kamon1422034115633
Jian Yang1421818111166
I. V. Gorelov1391916103133
S. R. Hou1391845106563
Kaori Maeshima1391850105218
Jiangyong Jia138117391163
Kenneth Bloom1381958110129
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202315
2022111
20212,414
20202,356
20192,330
20182,349