scispace - formally typeset
Search or ask a question
Institution

Academia Sinica

FacilityTaipei, Taiwan
About: Academia Sinica is a facility organization based out in Taipei, Taiwan. It is known for research contribution in the topics: Population & Galaxy. The organization has 52086 authors who have published 65998 publications receiving 1728114 citations. The organization is also known as: Central Research Academy.


Papers
More filters
PatentDOI
TL;DR: In this article, a method for labeling of cellular glycans bearing azide groups via a fluorescent labeling technique based on Cu(I)-catalyzed [3+2]cycloaddition (click activation) of a probe comprising an alkynyl group is presented.
Abstract: The disclosure provides a method of labeling of cellular glycans bearing azide groups via a fluorescent labeling technique based on Cu(I)-catalyzed [3+2]cycloaddition (click activation) of a probe comprising an alkynyl group. The method entails generating a fluorescent probe from a nonfluorescent precursor, 4-ethynyl-N-ethyl-1,8-naphthalimide, by Cu(I)-catalyzed [3+2]cycloaddition of the alkyne group of the probe with an azido-modified sugar. The disclosure further provides a method of incorporating an azido-containing fucose analog into glycoconjugates via the fucose salvage pathway. The disclosure provides a method of fluorescent visualization of fucosylated cells by flow cytometry when cells treated with 6-azidofucose are labeled with the click-activated fluorogenic probe or biotinylated alkyne. A method of visualizing the intracellular localization of fucosylated glycoconjugates by fluorescence microscopy is also disclosed.

404 citations

Journal ArticleDOI
Joseph Adams1, C. Adler2, Madan M. Aggarwal3, Zubayer Ahammed4  +366 moreInstitutions (41)
TL;DR: In this article, the authors reconstructed hadrons in 0.15 4 4 GeV/c collisions with pp and Au+Au at the radical (s{sub NN}) = 200 GeV and the associated multiplicity and p{sub perpendicular} magnitude sum were found to increase from pp to central Au+AU collisions.
Abstract: Charged hadrons in 0.15 4 GeV/c are reconstructed in pp and Au+Au collisions at {radical}(s{sub NN})=200 GeV. The associated multiplicity and p{sub perpendicular} magnitude sum are found to increase from pp to central Au+Au collisions. The associated p{sub perpendicular} distributions, while similar in shape on the nearside, are significantly softened on the awayside in central Au+Au relative to pp and not much harder than that of inclusive hadrons. The results, consistent with jet quenching, suggest that the awayside fragments approach equilibration with the medium traversed.

403 citations

Journal ArticleDOI
TL;DR: The use of recombinant DNA technology to produce large quantities of lipases, and the use of immobilized lipases and immobilized whole cells, may lower the overall cost, while presenting less downstream processing problems, to biodiesel production.
Abstract: The need for alternative energy sources that combine environmental friendliness with biodegradability, low toxicity, renewability, and less dependence on petroleum products has never been greater. One such energy source is referred to as biodiesel. This can be produced from vegetable oils, animal fats, microalgal oils, waste products of vegetable oil refinery or animal rendering, and used frying oils. Chemically, they are known as monoalkyl esters of fatty acids. The conventional method for producing biodiesel involves acid and base catalysts to form fatty acid alkyl esters. Downstream processing costs and environmental problems associated with biodiesel production and byproducts recovery have led to the search for alternative production methods and alternative substrates. Enzymatic reactions involving lipases can be an excellent alternative to produce biodiesel through a process commonly referred to alcoholysis, a form of transesterification reaction, or through an interesterification (ester interchange) reaction. Protein engineering can be useful in improving the catalytic efficiency of lipases as biocatalysts for biodiesel production. The use of recombinant DNA technology to produce large quantities of lipases, and the use of immobilized lipases and immobilized whole cells, may lower the overall cost, while presenting less downstream processing problems, to biodiesel production. In addition, the enzymatic approach is environmentally friendly, considered a "green reaction", and needs to be explored for industrial production of biodiesel.

403 citations

Journal ArticleDOI
TL;DR: In this paper, the authors focus on the problems which arise when available data are restricted to the distribution of factor incomes between groups of families defined by their total income level, and the results obtained required exploration of the alternative concepts and measurements which are possible when individual family data are available.
Abstract: This paper furthers the discussion of income inequality decomposition by focusing attention on the problems which arise in this context when available data are restricted to the distribution of factor incomes between groups of families defined by their total income level. First, it sets out the Rao (1969) decomposition of the Gini coefficient for total income in terms of factor shares and factor concentration ratios. Further decomposition of concentration ratios into rank correlation ratios and factor Ginis is recommended when individual data are available. Second, interpretation of concentration ratios as Gini coefficients is shown to be misleading. An analogue in economic theory is required. The results obtained required exploration of the alternative concepts and measurements which are possible when individual family data are available. In turn, these had to be related to the more limited set of concepts which can be calibrated when available data are taken from a secondary source. Caution is advised in interpreting results based on secondary sources of income inequality by factor components.

403 citations

Journal ArticleDOI
TL;DR: SNPs at four loci were associated with ER-negative but not ER-positive breast cancer (P > 0.05), providing further evidence for distinct etiological pathways associated with invasive ER- positive and ER- negative breast cancers.
Abstract: Estrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a meta-analysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P = 2.1 × 10(-12) and LGR6, P = 1.4 × 10(-8)), 2p24.1 (P = 4.6 × 10(-8)) and 16q12.2 (FTO, P = 4.0 × 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P > 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers.

402 citations


Authors

Showing all 52129 results

NameH-indexPapersCitations
Yi Chen2174342293080
Jing Wang1844046202769
Jie Zhang1784857221720
Hyun-Chul Kim1764076183227
Yang Yang1642704144071
Yuh Nung Jan16246074818
Jongmin Lee1502257134772
Hui-Ming Cheng147880111921
Teruki Kamon1422034115633
Jian Yang1421818111166
I. V. Gorelov1391916103133
S. R. Hou1391845106563
Kaori Maeshima1391850105218
Jiangyong Jia138117391163
Kenneth Bloom1381958110129
Network Information
Related Institutions (5)
Chinese Academy of Sciences
634.8K papers, 14.8M citations

95% related

Centre national de la recherche scientifique
382.4K papers, 13.6M citations

93% related

Max Planck Society
406.2K papers, 19.5M citations

91% related

Pennsylvania State University
196.8K papers, 8.3M citations

91% related

Spanish National Research Council
220.4K papers, 7.6M citations

91% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202315
2022111
20212,414
20202,356
20192,330
20182,349