Institution
ACADIA Pharmaceuticals Inc.
Company•San Diego, California, United States•
About: ACADIA Pharmaceuticals Inc. is a company organization based out in San Diego, California, United States. It is known for research contribution in the topics: Pimavanserin & Receptor. The organization has 260 authors who have published 276 publications receiving 8418 citations.
Papers published on a yearly basis
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TL;DR: In the chronic complete Freund's adjuvant model, ERb-131 resolved both inflammatory and hyperalgesic components and is sufficient to alleviate chronic but not acute inflammatory pain states.
26 citations
TL;DR: It was shown by a combination of X-ray crystallography and chemical correlation that the activity resides in the S-enantiomer of 5d, with N-[1-(4-chlorophenyl)-3-(dimethylamino)-propyl]-4-phenylbenzamide oxalate (5d) being the most potent.
Abstract: Six different series of nonpeptidic urotensin II receptor agonists have been synthesized and evaluated for their agonistic activity in a cell-based assay (R-SAT). The compounds are ring-opened analogues of the isochromanone-based agonist AC-7954 with different functionalities constituting the linker between the two aromatic ring moieties. Several of the compounds are highly potent and efficacious, with N-[1-(4-chlorophenyl)-3-(dimethylamino)-propyl]-4-phenylbenzamide oxalate (5d) being the most potent. The pure enantiomers of 5d were obtained from the corresponding diastereomeric amides. It was shown by a combination of X-ray crystallography and chemical correlation that the activity resides in the S-enantiomer of 5d (pEC50 7.49).
26 citations
TL;DR: The pyridine based PLG-mimetic was evaluated for its ability to enhance the maximum response of the dopamine agonist N-propylapomorphine at human D2 receptors using a cell based assay (the R-SAT assay).
Abstract: A 2,3,4-substituted pyridine derivative has been identified as a potential tripeptidomimetic scaffold. The design of the scaffold was based on conformational and electrostatic comparisons with a na ...
26 citations
TL;DR: In this article, a novel solid phase synthesis of tertiary amines involving iodide-induced cleavage of the N O bond of resin bound alkoxyammonium intermediates is described.
26 citations
TL;DR: Temporary tethering using aluminum or zinc in Diels-Alder reactions made possible the use of otherwise "noncompatible" combinations of dienes and dienophiles, resulting in the one-step formation of substituted cyclohexene 1,2-bis-methanols.
25 citations
Authors
Showing all 261 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Michael Bachmann | 63 | 360 | 14388 |
| Daniel P. van Kammen | 47 | 168 | 6957 |
| Kristina Luthman | 39 | 158 | 7344 |
| Fredrik Almqvist | 37 | 170 | 4219 |
| Mark R. Brann | 35 | 77 | 5579 |
| Roger Olsson | 30 | 138 | 2752 |
| Uli Hacksell | 29 | 99 | 2954 |
| Torbjörn Frejd | 29 | 165 | 2889 |
| Petrine Wellendorph | 27 | 83 | 2573 |
| Ethan S. Burstein | 27 | 70 | 2255 |
| David M. Weiner | 26 | 45 | 3230 |
| Kimberly E. Vanover | 25 | 70 | 1955 |
| Uli Hacksell | 25 | 129 | 2879 |
| Magnus Gustafsson | 25 | 94 | 1546 |
| Mark R. Brann | 24 | 39 | 2576 |