Adama University

About: Adama University is a education organization based out in Nazrēt, Ethiopia. It is known for research contribution in the topics: Population & Adsorption. The organization has 840 authors who have published 1010 publications receiving 5547 citations. The organization is also known as: Adama Science and Technology University & ቴክኖሎጂ ዩኒቨርሲቲ, አዳማ ሳይንስና ቴክኖሎጂ ዩኒቨርሲቲ.

Approximate l-States Solutions to the Schrodinger Equation with Manning-Rosen plus Hellmann Potential via WKB Approximation Scheme

Abstract: The approximate analytical solutions of the radial Schrodinger equation have been obtained by the interaction of Manning-Rosen and Hellmann potentials which is a newly proposed potential. Using the Wentzel-Kramers-Brillouin WKB approach, we obtained the eigenstates solutions for any arbitrary angular momentum. Special cases of potential consideration have been discussed. Eigenenergy solutions to equations obtained play an important role in quantum mechanics because they contain a wealth of vital information regarding the system under consideration.

Ultrasensitive nanohybrid electrochemical sensor to detect LipL32 gene of Leptospira interrogans

Abstract: We report an ultrasensitive nanohybrid electrochemical DNA sensor developed to detect the LipL32 gene of Leptospira interrogans that causes leptospirosis. A carboxylated multiwalled carbon nanotubes electrode with gold nanoparticles (c-MWCNTs/nano-Au) was modified with polyamidoamine (PAMAM) and graphene quantum dots using cysteine (Cys) as a linker. The c-MWCNTs/nano-Au electrode was covalently bonded to polyamidoamine (PAMAM) via Cys through Au-SH bonding. The amino group of PAMAM was linked to carboxyl moiety of graphene quantum dots (GQD) to form a c-MWCNTs/nano-Au/Cys/PAMAM/GQD nanohybrid electrode. A 5’-amino (NH2) labeled single-stranded DNA (ssDNA) probe based on the LipL32 gene was immobilized on the surface of a c-MWCNTs/nano-Au/Cys/PAMAM/GQD nanohybrid electrode. The different dilutions of single-stranded genomic DNA (ssG-DNA) of L. interrogans were treated on immobilized DNA probe to allow the hybridization. The hybridization events are measured using cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS) using redox indicators of 1 mM methylene blue and potassium ferricyanide. Field emission scanning electron microscopy (FE-SEM) was performed to analyze the modifications done on the surface of the electrode. The developed nanohybrid sensor has a sensitivity of 1952.3 µA cm−2 ng−1 and a lower limit of detection (LOD) of 0.112 pg/µl (R2 = 0.98). The nanohybrid sensor showed good reproducibility over a period of 6 months, exhibiting only a 10% loss in actual DPV current. The developed nanohybrid sensor is found to be specific to L. interrogans with high sensitivity and reproducibility, and it can be used for routine analysis for L. interrogans identification and leptospirosis diagnosis.

Design, Synthesis, Characterization and in vivo Antidiabetic Activity Evaluation of Some Chalcone Derivatives.

Abstract: Background Diabetes is one of the growing health problems worldwide, and scientists have been striving to find effective treatment methods. In this regard, chalcones have frequently been targeted by many researchers owing to their diverse biological activities. Methods Here, the Claisen-Schmidt condensation reaction was applied to synthesize five chalcone derivatives. The chalcone derivatives were evaluated for their relative antidiabetic activities in vivo using streptozotocin (STZ)-induced diabetic mice. Besides, the compounds were assessed for their reduction in postprandial hyperglycemia at 50 and 100 mg/kg dose levels against a standard drug, glibenclamide. In addition, the structure-activity relationship (SAR) was analyzed to determine the effect of structural modification in chalcones activity. Results A dose-dependent reduction in postprandial hyperglycemia was observed. The highest reduction in blood glucose level (BGL) was achieved by compound 3 at a dose of 100 mg/kg (39%). This was found to be even higher than glibenclamide (34.5%). In the STZ-induced diabetic animal model, all test compounds showed comparable efficacy with glibenclamide. The SAR analysis revealed that the incorporation of electron-donating groups at position 5 of the benzaldehyde ring and position 2 of the acetophenone ring is promising to increase the antihyperglycemic activities of chalcones. Conclusion The chalcone derivatives considered in this study could be used as potential lead compounds in the discovery of effective drugs to treat diabetes mellitus.