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Institution

Advanced Technologies Center

About: Advanced Technologies Center is a based out in . It is known for research contribution in the topics: Scanning probe microscopy & Digital signature. The organization has 86 authors who have published 74 publications receiving 1978 citations.


Papers
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Journal ArticleDOI
TL;DR: This review provides a detailed analysis of the various factors affecting the morphology, size, and yield of metal nanoparticles.
Abstract: While metal nanoparticles are being increasingly used in many sectors of the economy, there is growing interest in the biological and environmental safety of their production. The main methods for nanoparticle production are chemical and physical approaches that are often costly and potentially harmful to the environment. The present review is devoted to the possibility of metal nanoparticle synthesis using plant extracts. This approach has been actively pursued in recent years as an alternative, efficient, inexpensive, and environmentally safe method for producing nanoparticles with specified properties. This review provides a detailed analysis of the various factors affecting the morphology, size, and yield of metal nanoparticles. The main focus is on the role of the natural plant biomolecules involved in the bioreduction of metal salts during the nanoparticle synthesis. Examples of effective use of exogenous biomatrices (peptides, proteins, and viral particles) to obtain nanoparticles in plant extracts are discussed.

1,152 citations

Journal ArticleDOI
TL;DR: It is found that PAX3-FOXO1 establishes a myoblastic super enhancer landscape and creates a profound subtype-unique dependence on BET bromodomains, providing a mechanistic rationale for exploring BET inhibitors for patients bearing PAX-fusion rhabdomyosarcoma.
Abstract: Alveolar rhabdomyosarcoma is a life-threatening myogenic cancer of children and adolescent young adults, driven primarily by the chimeric transcription factor PAX3-FOXO1. The mechanisms by which PAX3-FOXO1 dysregulates chromatin are unknown. We find PAX3-FOXO1 reprograms the cis-regulatory landscape by inducing de novo super enhancers. PAX3-FOXO1 uses super enhancers to set up autoregulatory loops in collaboration with the master transcription factors MYOG, MYOD, and MYCN. This myogenic super enhancer circuitry is consistent across cell lines and primary tumors. Cells harboring the fusion gene are selectively sensitive to small-molecule inhibition of protein targets induced by, or bound to, PAX3-FOXO1-occupied super enhancers. Furthermore, PAX3-FOXO1 recruits and requires the BET bromodomain protein BRD4 to function at super enhancers, resulting in a complete dependence on BRD4 and a significant susceptibility to BRD inhibition. These results yield insights into the epigenetic functions of PAX3-FOXO1 and reveal a specific vulnerability that can be exploited for precision therapy.Significance: PAX3-FOXO1 drives pediatric fusion-positive rhabdomyosarcoma, and its chromatin-level functions are critical to understanding its oncogenic activity. We find that PAX3-FOXO1 establishes a myoblastic super enhancer landscape and creates a profound subtype-unique dependence on BET bromodomains, the inhibition of which ablates PAX3-FOXO1 function, providing a mechanistic rationale for exploring BET inhibitors for patients bearing PAX-fusion rhabdomyosarcoma. Cancer Discov; 7(8); 884-99. ©2017 AACR.This article is highlighted in the In This Issue feature, p. 783.

200 citations

Journal ArticleDOI
TL;DR: The AFM results show that the two strains have considerable difference in the surface morphology and at the same time after rehydration both strains show the loss of the topographic features and increase in lateral and vertical dimensions.

151 citations

Journal ArticleDOI
TL;DR: Resuscitation extracorporeal membrane oxygenation is an appropriate application in pediatric patients with cardiac disease and single ventricle patients experiencing cardiopulmonary collapse and CMM patients have favorable outcomes.

104 citations

Journal ArticleDOI
TL;DR: In this article, the stabilities of olivine LiFePO 4 and spinel LiMn 2 O 4 in a LiPF 6 -based electrolyte were investigated by means of atomic absorption spectroscopy.

100 citations


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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20214
20207
20194
20189
20176
20168