Institution
Agency for Science, Technology and Research
Government•Singapore, Singapore•
About: Agency for Science, Technology and Research is a government organization based out in Singapore, Singapore. It is known for research contribution in the topics: Population & Catalysis. The organization has 16013 authors who have published 24427 publications receiving 832302 citations. The organization is also known as: A*STAR & A-Star.
Topics: Population, Catalysis, Stem cell, Thin film, Immune system
Papers published on a yearly basis
Papers
More filters
••
TL;DR: Mononuclear phagocyte plasticity includes the expression of functions related to the resolution of inflammation, tissue repair and remodelling, particularly when these cells are set in an M1 or an M2‐like activation mode.
Abstract: Mononuclear phagocyte plasticity includes the expression of functions related to the resolution of inflammation, tissue repair and remodelling, particularly when these cells are set in an M2 or an M2-like activation mode. Macrophages are credited with an essential role in remodelling during ontogenesis. In extraembryonic life, under homeostatic conditions, the macrophage trophic and remodelling functions are recapitulated in tissues such as bone, mammary gland, decidua and placenta. In pathology, macrophages are key components of tissue repair and remodelling that occur during wound healing, allergy, parasite infection and cancer. Interaction with cells bearing stem or progenitor cell properties is likely an important component of the role of macrophages in repair and remodelling. These properties of cells of the monocyte-macrophage lineage may represent a tool and a target for therapeutic exploitation.
1,884 citations
••
TL;DR: A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function, and these findings suggest potential novel therapeutic pathways for cardiovascular disease prevention.
Abstract: Blood pressure is a heritable trait(1) influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (>= 140 mm Hg systolic blood pressure or >= 90 mm Hg diastolic blood pressure)(2). Even small increments in blood pressure are associated with an increased risk of cardiovascular events(3). This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.
1,829 citations
••
TL;DR: This review aims to summarize major developments in the field of lithium-sulfur batteries, starting from an overview of their electrochemistry, technical challenges and potential solutions, along with some theoretical calculation results to advance the understanding of the material interactions involved.
Abstract: Due to their high energy density and low material cost, lithium–sulfur batteries represent a promising energy storage system for a multitude of emerging applications, ranging from stationary grid storage to mobile electric vehicles. This review aims to summarize major developments in the field of lithium–sulfur batteries, starting from an overview of their electrochemistry, technical challenges and potential solutions, along with some theoretical calculation results to advance our understanding of the material interactions involved. Next, we examine the most extensively-used design strategy: encapsulation of sulfur cathodes in carbon host materials. Other emerging host materials, such as polymeric and inorganic materials, are discussed as well. This is followed by a survey of novel battery configurations, including the use of lithium sulfide cathodes and lithium polysulfide catholytes, as well as recent burgeoning efforts in the modification of separators and protection of lithium metal anodes. Finally, we conclude with an outlook section to offer some insight on the future directions and prospects of lithium–sulfur batteries.
1,816 citations
••
TL;DR: The novel role of exosomes highlights a new perspective into intercellular mediation of tissue injury and repair, and engenders novel approaches to the development of biologics for tissue repair.
1,816 citations
••
TL;DR: Results indicate that tissue-resident macrophages and circulating monocytes should be classified as mononuclear phagocyte lineages that are independently maintained in the steady state.
1,771 citations
Authors
Showing all 16109 results
Name | H-index | Papers | Citations |
---|---|---|---|
Patrick O. Brown | 183 | 755 | 200985 |
Alberto Mantovani | 183 | 1397 | 163826 |
Paul G. Richardson | 183 | 1533 | 155912 |
Barry Halliwell | 173 | 662 | 159518 |
Tien Yin Wong | 160 | 1880 | 131830 |
Leroy Hood | 158 | 853 | 128452 |
Johan G. Eriksson | 156 | 1257 | 123325 |
Nancy A. Jenkins | 155 | 741 | 101587 |
Neal G. Copeland | 154 | 726 | 100130 |
Rui Zhang | 151 | 2625 | 107917 |
Seeram Ramakrishna | 147 | 1552 | 99284 |
Mark M. Davis | 144 | 581 | 74358 |
Bin Liu | 138 | 2181 | 87085 |
Michael J. Meaney | 136 | 604 | 81128 |
Michael R. Hayden | 135 | 891 | 73619 |