Agilent Technologies

About: Agilent Technologies is a company organization based out in Santa Clara, California, United States. It is known for research contribution in the topics: Signal & Mass spectrometry. The organization has 7398 authors who have published 11518 publications receiving 262410 citations. The organization is also known as: Agilent Technologies, Inc..

Widely tunable single-mode quantum cascade laser source for mid-infrared spectroscopy

Abstract: We demonstrate a compact, single-mode quantum cascade laser source continuously tunable between 8.7 and 9.4μm. The source consists of an array of single-mode distributed feedback quantum cascade lasers with closely spaced emission wavelengths fabricated monolithically on a single chip and driven by a microelectronic controller. Our source is suitable for a variety of chemical sensing applications. Here, we use it to perform absorption spectroscopy of fluids.

Electropolymerized Polyaniline Stabilized Tungsten Oxide Nanocomposite Films: Electrochromic Behavior and Electrochemical Energy Storage

Abstract: Polyaniline (PANI)/tungsten oxide (WO3) nanocomposite films were fabricated by electropolymerization of aniline monomers onto WO3 coated indium tin oxide (ITO) glass slides, which were prepared by spin coating technique and followed by annealing at 500 °C for 2 h. The morphology and crystalline structure of the composite films were studied using Fourier transform infrared (FT-IR) spectroscopy, atomic force microscopy (AFM), X-ray diffraction (XRD), and transmission electron microscopy (TEM). The results confirm chemical interactions between the polymer matrix and the WO3 particles and reveal a well crystallized PANI/WO3 nanocomposite structure. The optical properties and electrochemical capacitive behaviors of the composite films for electrochromic (EC) and energy storage devices applications were investigated using spectroelectrochemistry (SEC), cyclic voltammetry (CV) and galvanostatic charge–discharge measurements. The composite films show dual electrochromism at both positive and negative potentials a...

Toward Structurally Defined Carbon Dots as Ultracompact Fluorescent Probes

Abstract: There has been much discussion on the need to develop fluorescent quantum dots (QDs) as ultracompact probes, with overall size profiles comparable to those of the genetically encoded fluorescent tags. In the use of conventional semiconductor QDs for such a purpose, the beautifully displayed dependence of fluorescence color on the particle diameter becomes a limitation. More recently, carbon dots have emerged as a new platform of QD-like fluorescent nanomaterials. The optical absorption and fluorescence emissions in carbon dots are not bandgap in origin, different from those in conventional semiconductor QDs. The absence of any theoretically defined fluorescence color - dot size relationships in carbon dots may actually be exploited as a unique advantage in the size reduction toward having carbon dots serve as ultracompact QD-like fluorescence probes. Here we report on carbon dots of less than 5 nm in the overall dot diameter with the use of 2,2′-(ethylenedioxy)bis(ethylamine) (EDA) molecules for the carbo...

Hybrid selection of discrete genomic intervals on custom-designed microarrays for massively parallel sequencing.

Abstract: Complementary techniques that deepen information content and minimize reagent costs are required to realize the full potential of massively parallel sequencing. Here, we describe a resequencing approach that directs focus to genomic regions of high interest by combining hybridization-based purification of multi-megabase regions with sequencing on the Illumina Genome Analyzer (GA). The capture matrix is created by a microarray on which probes can be programmed as desired to target any non-repeat portion of the genome, while the method requires only a basic familiarity with microarray hybridization. We present a detailed protocol suitable for 1-2 microg of input genomic DNA and highlight key design tips in which high specificity (>65% of reads stem from enriched exons) and high sensitivity (98% targeted base pair coverage) can be achieved. We have successfully applied this to the enrichment of coding regions, in both human and mouse, ranging from 0.5 to 4 Mb in length. From genomic DNA library production to base-called sequences, this procedure takes approximately 9-10 d inclusive of array captures and one Illumina flow cell run.

A controlled experiment for evaluating quality guidelines on the maintainability of object-oriented designs

Abstract: The paper presents a controlled experiment, focusing on the impact of applying quality design principles such as the ones provided by P. Coad and E. Yourdon (1991) on the maintainability of object oriented designs. Results, which repeat the findings of a previous study, strongly suggest that such design principles have a beneficial effect on the maintainability of object oriented designs. It is argued that object oriented designs are sensitive to poor design practices because the cognitive complexity introduced becomes increasingly unmanageable. However, as our ability to generalize these results is limited, they should be considered as preliminary, i.e., it is very likely that they can only be generalized to programmers with little object oriented training and programming experience. Such programmers can, however, be commonly found on maintenance projects. As well as additional research, external replications of this study are required to confirm the results and achieve confidence in these findings.