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Institution

Agilent Technologies

CompanySanta Clara, California, United States
About: Agilent Technologies is a company organization based out in Santa Clara, California, United States. It is known for research contribution in the topics: Signal & Mass spectrometry. The organization has 7398 authors who have published 11518 publications receiving 262410 citations. The organization is also known as: Agilent Technologies, Inc..


Papers
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Journal ArticleDOI
TL;DR: Results demonstrate that a T2D-associated gene plays an important role in tumour development and that its expression is strictly controlled at the mRNA and protein levels.
Abstract: Cancer stem cells (CSCs) have been identified in various types of cancer; however, the mechanisms by which cells acquire CSC properties such as drug resistance and tumour seeding ability are not fully understood. Here, we identified microRNA-27b (miR-27b) as a key regulator for the generation of a side-population in breast cancer cells that showed CSC properties, and also found that the anti-type II diabetes (T2D) drug metformin reduced this side-population via miR-27b-mediated repression of ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1), which is involved in T2D development. ENPP1 induced the generation of the side-population via upregulation of the ABCG2 transporter. ENPP1 was also identified as a substrate of the 26S proteasome, the activity of which is downregulated in CSCs. Overall, these results demonstrate that a T2D-associated gene plays an important role in tumour development and that its expression is strictly controlled at the mRNA and protein levels.

126 citations

Patent
05 Mar 2001
TL;DR: In this paper, a method for fabricating a resonator, and in particular a thin film bulk acoustic resonator (FBAR), and a resonance embodying the method is disclosed.
Abstract: A method for fabricating a resonator, and in particular, a thin film bulk acoustic resonator (FBAR), and a resonator embodying the method are disclosed. An FBAR is fabricated on a substrate by mass loading piezoelectric (PZ) layer between two electrodes. For a substrate having multiple resonators, only selected resonator is mass loaded to provide resonators having different resonance frequencies on the same substrate.

125 citations

Patent
18 Jun 1998
TL;DR: In this paper, a plurality of electrodes supported by a semiconductor substrate is brought into proximity with a reaction medium, which comprises reagents for carrying out the chemical reactions, and an item of numerical data is sent to the storage means in each of the cells within the substrate by means of a data bus.
Abstract: Methods and devices are disclosed for carrying out multiple chemical reactions A plurality of electrodes supported by a semiconductor substrate is brought into proximity with a reaction medium, which comprises reagents for carrying out the chemical reactions An item of numerical data is sent to storage means in each of a plurality of cells within the semiconductor substrate by means of a data bus The item of numerical data is representative of an electric signal An address is sent to address decoders in communication with the storage means As a result, the item of numerical data is stored in the storage means Electric signals are selectively applied to each of the electrodes by means of a plurality of digital analog converters, each electrically coupled to a respective electrode Each of the digital analog converters is associated with a respective cell In this way, a chemical reaction takes place proximal to and in response to the field at the electrodes to which the electric signals are selectively applied A particular feature of the present invention is that the medium may be non-aqueous

125 citations

Journal ArticleDOI
TL;DR: The UPLC-based glycan analysis technique described here reveals highly significant differences between healthy women and breast cancer patients, and systemic features show more significant associations with the serum N-glycome than do features of the breast carcinomas.
Abstract: An improved separation of the human serum N-glycome using hydrophilic interaction chromatography technology with UPLC is described, where more than 140 N-glycans were assigned. Using this technique...

125 citations

Patent
06 Oct 1999
TL;DR: In this paper, a system and method for evaluating logical values from target systems is presented, which includes a configuration in a field programmable gate array for performing a doubly bounded comparison.
Abstract: A system and method are provided to evaluate logical values from target systems. The system includes a configuration in a field programmable gate array for performing a doubly bounded comparison. The configuration advantageously allows the user to determine when values are greater than or less than a predefined value while employing a reduced number of lookup tables in the field programmable gate array. The configuration includes an input to receive a parallel logical value. The system also includes a number of equality lookup tables configured to detect an equality between a portion of the logical value and a portion of a predefined value. The system also includes a number of inequality lookup tables configured to determine a type of an inequality between the portion of the logical value and the portion of the predefined value. The predefined value is preprogrammed and downloaded to the equality lookup tables at startup. The inequality lookup tables each include an output that is applied to an OR function, thereby producing an output.

125 citations


Authors

Showing all 7402 results

NameH-indexPapersCitations
Hongjie Dai197570182579
Zhuang Liu14953587662
Jie Liu131153168891
Thomas Quertermous10340552437
John E. Bowers102176749290
Roy G. Gordon8944931058
Masaru Tomita7667740415
Stuart Lindsay7434722224
Ron Shamir7431923670
W. Richard McCombie7114464155
Tomoyoshi Soga7139221209
Michael R. Krames6532118448
Shabaz Mohammed6418817254
Geert Leus6260919492
Giuseppe Gigli6154115159
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
20231
20228
2021142
2020157
2019168
2018164