Institution
Agrocampus Ouest
Education•Rennes, France•
About: Agrocampus Ouest is a education organization based out in Rennes, France. It is known for research contribution in the topics: Population & Casein. The organization has 2160 authors who have published 3219 publications receiving 75606 citations. The organization is also known as: Institut supérieur des sciences agronomiques, agroalimentaires, horticoles et du paysage & Higher Institute for agricultural sciences, food industry, horticulture and landscape management.
Topics: Population, Casein, Soil water, Lactation, Whey protein
Papers published on a yearly basis
Papers
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TL;DR: FactoMineR an R package dedicated to multivariate data analysis with the possibility to take into account different types of variables (quantitative or categorical), different kinds of structure on the data, and finally supplementary information (supplementary individuals and variables).
Abstract: In this article, we present FactoMineR an R package dedicated to multivariate data analysis. The main features of this package is the possibility to take into account different types of variables (quantitative or categorical), different types of structure on the data (a partition on the variables, a hierarchy on the variables, a partition on the individuals) and finally supplementary information (supplementary individuals and variables). Moreover, the dimensions issued from the different exploratory data analyses can be automatically described by quantitative and/or categorical variables. Numerous graphics are also available with various options. Finally, a graphical user interface is implemented within the Rcmdr environment in order to propose an user friendly package.
6,472 citations
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Chalmers University of Technology1, Institut national de la recherche agronomique2, Agrocampus Ouest3, Aix-Marseille University4, University of Guelph5, Massey University6, Ege University7, Agro ParisTech8, Norwich Research Park9, Norwich University10, University of Massachusetts Amherst11, Spanish National Research Council12, Universidade Nova de Lisboa13, University of California, Davis14, Norwegian University of Life Sciences15, University of Greifswald16, Teagasc17
TL;DR: In this article, the authors proposed a general standardised and practical static digestion method based on physiologically relevant conditions that can be applied for various endpoints, which may be amended to accommodate further specific requirements.
Abstract: Simulated gastro-intestinal digestion is widely employed in many fields of food and nutritional sciences, as conducting human trials are often costly, resource intensive, and ethically disputable. As a consequence, in vitro alternatives that determine endpoints such as the bioaccessibility of nutrients and non-nutrients or the digestibility of macronutrients (e.g. lipids, proteins and carbohydrates) are used for screening and building new hypotheses. Various digestion models have been proposed, often impeding the possibility to compare results across research teams. For example, a large variety of enzymes from different sources such as of porcine, rabbit or human origin have been used, differing in their activity and characterization. Differences in pH, mineral type, ionic strength and digestion time, which alter enzyme activity and other phenomena, may also considerably alter results. Other parameters such as the presence of phospholipids, individual enzymes such as gastric lipase and digestive emulsifiers vs. their mixtures (e.g. pancreatin and bile salts), and the ratio of food bolus to digestive fluids, have also been discussed at length. In the present consensus paper, within the COST Infogest network, we propose a general standardised and practical static digestion method based on physiologically relevant conditions that can be applied for various endpoints, which may be amended to accommodate further specific requirements. A frameset of parameters including the oral, gastric and small intestinal digestion are outlined and their relevance discussed in relation to available in vivo data and enzymes. This consensus paper will give a detailed protocol and a line-by-line, guidance, recommendations and justifications but also limitation of the proposed model. This harmonised static, in vitro digestion method for food should aid the production of more comparable data in the future.
3,380 citations
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Teagasc1, Chalmers University of Technology2, University of Aveiro3, SupAgro4, Agrocampus Ouest5, Centre national de la recherche scientifique6, Spanish National Research Council7, Aarhus University8, Institut national de la recherche agronomique9, Norwich University10, Massey University11, Ege University12, Technion – Israel Institute of Technology13, Gdańsk University of Technology14, University of Leeds15, University of Massachusetts Amherst16, Universidade Nova de Lisboa17, Université Paris-Saclay18, University of California, Davis19, Norwegian University of Life Sciences20, University of Greifswald21
TL;DR: This amended and improved digestion method (INFOGEST 2.0) avoids challenges associated with the original method, such as the inclusion of the oral phase and the use of gastric lipase.
Abstract: Developing a mechanistic understanding of the impact of food structure and composition on human health has increasingly involved simulating digestion in the upper gastrointestinal tract. These simulations have used a wide range of different conditions that often have very little physiological relevance, and this impedes the meaningful comparison of results. The standardized protocol presented here is based on an international consensus developed by the COST INFOGEST network. The method is designed to be used with standard laboratory equipment and requires limited experience to encourage a wide range of researchers to adopt it. It is a static digestion method that uses constant ratios of meal to digestive fluids and a constant pH for each step of digestion. This makes the method simple to use but not suitable for simulating digestion kinetics. Using this method, food samples are subjected to sequential oral, gastric and intestinal digestion while parameters such as electrolytes, enzymes, bile, dilution, pH and time of digestion are based on available physiological data. This amended and improved digestion method (INFOGEST 2.0) avoids challenges associated with the original method, such as the inclusion of the oral phase and the use of gastric lipase. The method can be used to assess the endpoints resulting from digestion of foods by analyzing the digestion products (e.g., peptides/amino acids, fatty acids, simple sugars) and evaluating the release of micronutrients from the food matrix. The whole protocol can be completed in ~7 d, including ~5 d required for the determination of enzyme activities.
1,394 citations
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Delft University of Technology1, UNESCO-IHE Institute for Water Education2, Vienna University of Technology3, University of Saskatchewan4, University of Illinois at Urbana–Champaign5, Swedish Meteorological and Hydrological Institute6, National Center for Atmospheric Research7, Karlsruhe Institute of Technology8, University of Bristol9, Russian Academy of Sciences10, University of Arizona11, Rhodes University12, University of Bologna13, University of Aberdeen14, Agrocampus Ouest15
TL;DR: The Prediction in Ungauged Basins (PUB) initiative of the International Association of Hydrological Sciences (IAHS) launched in 2003 and concluded by the PUB Symposium 2012 held in Delft (23-25 October 2012), set out to shift the scientific culture of hydrology towards improved scientific understanding of hydrological processes, as well as associated uncertainties and the development of models with increasing realism and predictive power as discussed by the authors.
Abstract: The Prediction in Ungauged Basins (PUB) initiative of the International Association of Hydrological Sciences (IAHS), launched in 2003 and concluded by the PUB Symposium 2012 held in Delft (23–25 October 2012), set out to shift the scientific culture of hydrology towards improved scientific understanding of hydrological processes, as well as associated uncertainties and the development of models with increasing realism and predictive power. This paper reviews the work that has been done under the six science themes of the PUB Decade and outlines the challenges ahead for the hydrological sciences community.Editor D. KoutsoyiannisCitation Hrachowitz, M., Savenije, H.H.G., Bloschl, G., McDonnell, J.J., Sivapalan, M., Pomeroy, J.W., Arheimer, B., Blume, T., Clark, M.P., Ehret, U., Fenicia, F., Freer, J.E., Gelfan, A., Gupta, H.V., Hughes, D.A., Hut, R.W., Montanari, A., Pande, S., Tetzlaff, D., Troch, P.A., Uhlenbrook, S., Wagener, T., Winsemius, H.C., Woods, R.A., Zehe, E., and Cudennec, C., 2013. A d...
848 citations
Chalmers University of Technology1, Agrocampus Ouest2, Institut national de la recherche agronomique3, Aix-Marseille University4, University of Guelph5, Massey University6, Ege University7, Agro ParisTech8, Norwich Research Park9, Norwich University10, University of Massachusetts Amherst11, Spanish National Research Council12, Universidade Nova de Lisboa13, University of California, Davis14, Norwegian University of Life Sciences15, University of Greifswald16, Teagasc17
TL;DR: A general standardised and practical static digestion method based on physiologically relevant conditions that can be applied for various endpoints, which may be amended to accommodate further specific requirements, is proposed.
Abstract: Simulated gastro-intestinal digestion is widely employed in many fields of food and nutritional sciences, as conducting human trials are often costly, resource intensive, and ethically disputable. As a consequence, in vitro alternatives that determine endpoints such as the bioaccessibility of nutrients and non-nutrients or the digestibility of macronutrients (e.g. lipids, proteins and carbohydrates) are used for screening and building new hypotheses. Various digestion models have been proposed, often impeding the possibility to compare results across research teams. For example, a large variety of enzymes from different sources such as of porcine, rabbit or human origin have been used, differing in their activity and characterization. Differences in pH, mineral type, ionic strength and digestion time, which alter enzyme activity and other phenomena, may also considerably alter results. Other parameters such as the presence of phospholipids, individual enzymes such as gastric lipase and digestive emulsifiers vs. their mixtures (e.g. pancreatin and bile salts), and the ratio of food bolus to digestive fluids, have also been discussed at length. In the present consensus paper, within the COST Infogest network, we propose a general standardised and practical static digestion method based on physiologically relevant conditions that can be applied for various endpoints, which may be amended to accommodate further specific requirements. A frameset of parameters including the oral, gastric and small intestinal digestion are outlined and their relevance discussed in relation to available in vivo data and enzymes. This consensus paper will give a detailed protocol and a line-by-line, guidance, recommendations and justifications but also limitation of the proposed model. This harmonised static, in vitro digestion method for food should aid the production of more comparable data in the future.
806 citations
Authors
Showing all 2169 results
Name | H-index | Papers | Citations |
---|---|---|---|
Jean Noblet | 62 | 213 | 11131 |
Jean-Pierre Renou | 58 | 206 | 11894 |
J. F. Le Borgne | 55 | 172 | 13954 |
Jean-Christophe Simon | 47 | 159 | 7226 |
Pierre Duhamel | 46 | 513 | 12627 |
Luc Delaby | 43 | 226 | 4880 |
Jacques Baudry | 43 | 150 | 7564 |
Jean-Yves Dourmad | 43 | 116 | 4770 |
Didier Dupont | 42 | 195 | 8137 |
Daniel Mollé | 41 | 111 | 5915 |
Gwénaël Jan | 41 | 104 | 4798 |
Sylvain Gaillard | 41 | 124 | 4917 |
Michel Bonneau | 40 | 162 | 4777 |
Jean-Paul Lallès | 39 | 149 | 6846 |
Chantal Gascuel-Odoux | 39 | 117 | 4520 |