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Institution

Aix-Marseille University

EducationMarseille, France
About: Aix-Marseille University is a education organization based out in Marseille, France. It is known for research contribution in the topics: Population & Galaxy. The organization has 24326 authors who have published 54240 publications receiving 1455416 citations. The organization is also known as: University Aix-Marseille & université d'Aix-Marseille.


Papers
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Journal ArticleDOI
TL;DR: It is reported that gold nanoapertures surrounded by periodic corrugations transform standard fluorescent molecules into bright unidirectional sources and the increased light-matter coupling as well as the radiation pattern intensity is quantified.
Abstract: Controlling the fluorescence emission from nanoscale quantum emitters is a key element for a wide range of applications, from efficient analytical sensing to quantum information processing. Enhancing the fluorescence intensity and narrowing the emission directivity are both essential features to achieve a full control of fluorescence, yet this is rarely obtained simultaneously with optical nanoantennas. Here we report that gold nanoapertures surrounded by periodic corrugations transform standard fluorescent molecules into bright unidirectional sources. We obtain enhancement factors of the fluorescence count rate per molecule up to 120 fold simultaneously with a directional emission of the fluorescence into a narrow angular cone in the direction normal to the sample plane. The bright emission and narrow directionality enable the detection of single molecules with a low numerical aperture objective, and improve the effectiveness of fluorescence-based applications. We thoroughly quantify the increased light-matter coupling as well as the radiation pattern intensity. These results are highly relevant for the development of single molecule sensing, single-photon sources, and light emitting devices.

301 citations

Journal ArticleDOI
TL;DR: An innovative drug delivery system based on a self-assembling amphiphilic dendrimer, which can generate supramolecular nanomicelles with large void space in their core to encapsulate anticancer drugs with high loading capacity, was established.
Abstract: Drug resistance and toxicity constitute challenging hurdles for cancer therapy. The application of nanotechnology for anticancer drug delivery is expected to address these issues and bring new hope for cancer treatment. In this context, we established an original nanomicellar drug delivery system based on an amphiphilic dendrimer (AmDM), which could generate supramolecular micelles to effectively encapsulate the anticancer drug doxorubicin (DOX) with high drug-loading capacity (>40%), thanks to the unique dendritic structure creating large void space for drug accommodation. The resulting AmDM/DOX nanomicelles were able to enhance drug potency and combat doxorubicin resistance in breast cancer models by significantly enhancing cellular uptake while considerably decreasing efflux of the drug. In addition, the AmDM/DOX nanoparticles abolished significantly the toxicity related to the free drug. Collectively, our studies demonstrate that the drug delivery system based on nanomicelles formed with the self-assembling amphiphilic dendrimer constitutes a promising and effective drug carrier in cancer therapy.

300 citations

Journal ArticleDOI
TL;DR: The economics profession appears to have been unaware of the long build-up to the current worldwide financial crisis, and to have significantly underestimated its dimensions once it started to unfold as mentioned in this paper.
Abstract: The economics profession appears to have been unaware of the long build-up to the current worldwide financial crisis and to have significantly underestimated its dimensions once it started to unfold. In our view, this lack of understanding is due to a misallocation of research efforts in economics. We trace the deeper roots of this failure to the profession's focus on models that, by design, disregard key elements driving outcomes in real-world markets. The economics profession has failed in communicating the limitations, weaknesses, and even dangers of its preferred models to the public. This state of affairs makes clear the need for a major reorientation of focus in the research economists undertake, as well as for the establishment of an ethical code that would ask economists to understand and communicate the limitations and potential misuses of their models.

300 citations

Journal ArticleDOI
TL;DR: The use of P1-type ATPases represents a M. tuberculosis strategy to neutralize the toxic effects of zinc in macrophages, suggesting that heavy metal toxicity and its counteraction might represent yet another chapter in the host-microbe arms race.

300 citations

Journal ArticleDOI
14 Aug 2013-JAMA
TL;DR: Among registry patients with mitral valve regurgitation due to flail mitral leaflets, performance of early mitral surgery compared with initial medical management was associated with greater long-term survival and a lower risk of heart failure, with no difference in new-onset atrial fibrillation.
Abstract: Among registry patients with mitral valve regurgitation due to flail mitral leaflets, performance of early mitral surgery compared with initial medical management was associated with greater long-term survival and a lower risk of heart failure, with no difference in new-onset atrial fibrillation

299 citations


Authors

Showing all 24784 results

NameH-indexPapersCitations
Didier Raoult1733267153016
Andrea Bocci1722402176461
Marc Humbert1491184100577
Carlo Rovelli1461502103550
Marc Besancon1431799106869
Jian Yang1421818111166
Josh Moss139101989255
Maksym Titov1391573128335
Bernard Henrissat139593100002
R. D. Kass1381920107907
Stylianos E. Antonarakis13874693605
Jean-Paul Kneib13880589287
Brad Abbott137156698604
Shu Li136100178390
Georges Aad135112188811
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023170
2022748
20215,607
20205,697
20195,288
20185,125