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Institution

Ajman University of Science and Technology

EducationAjman, United Arab Emirates
About: Ajman University of Science and Technology is a education organization based out in Ajman, United Arab Emirates. It is known for research contribution in the topics: Population & Pharmacy. The organization has 722 authors who have published 1305 publications receiving 10335 citations.


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Journal ArticleDOI
TL;DR: Blocking the somatodendritic 5-HT(1A) or nerve terminal alpha(2) receptors proved to increase the response rate in the treatment of major and treatment-resistant depression, providing further support to the assumption that the antidepressant effect results from the long-term adaptive changes in the monoamine auto- and heteroregulatory receptors.
Abstract: The role of the monoamines serotonin and noradrenaline in mental illnesses including depression is well recognized. All antidepressant drugs in clinical use increase acutely the availability of these monoamines at the synapse either by inhibiting their neuronal reuptake, inhibiting their intraneuronal metabolism, or increasing their release by blocking the alpha(2) auto- and heteroreceptors on the monoaminergic neuron. This acute increase in the amount of the monoamines at the synapse has been found to induce long-term adaptive changes in the monoamine systems that end up in the desensitization of the inhibitory auto- and heteroreceptors including the presynaptic alpha(2) and 5-HT(1B) receptors and the somatodendritic 5-HT(1A) receptors located in certain brain regions. The desensitization of these inhibitory receptors would result in higher central monoaminergic activity that coincides with the appearance of the therapeutic response. These adaptive changes responsible for the therapeutic effect depend on the availability of the specific monoamine at the synapse, as depletion of the monoamines will either reverse the antidepressant effect or causes a relapse in the state of drug-free depressed patient previously treated with antidepressant drugs. Furthermore, blocking the somatodendritic 5-HT(1A) or nerve terminal alpha(2) receptors proved to increase the response rate in the treatment of major and treatment-resistant depression, providing further support to the assumption that the antidepressant effect results from the long-term adaptive changes in the monoamine auto- and heteroregulatory receptors. On the other hand, the chronic treatment with antidepressants resulted in D(2) receptors supersensitivity in the nucleus accumbens. This supersensitivity might play a role in the mechanisms underlying antidepressant induced mood switch and rapid cycling.

460 citations

Journal ArticleDOI
TL;DR: The view that the causes and incidence of maxillofacial injuries vary from one country to another and, as such, can provide a guide to the design of programs geared toward prevention and treatment is supported.
Abstract: Objective Maxillofacial injuries constitute a substantial proportion of cases of trauma. This descriptive analytical study assesses the cause, type, incidence, demographic, and treatment data of maxillofacial fractures managed at Al Qassimi Hospital in Sharjah, United Arab Emirates, during a 4-year period and compares them with the existing body of literature on the subject. Study design The medical records and radiographs of 230 patients treated for maxillofacial fractures at the Al Qassimi General Hospital over a 4-year period (from 1999 to 2002) were reviewed. A number of parameters, including the patient's age, gender, race, occupation, and mechanism of injury, type of facial injuries, treatment modality, and postoperative complications were recorded and assessed. Results Men 20 to 29 years of age sustained the most maxillofacial fractures. The ratio of males to females was 11:1. Most fractures were caused by motor vehicle crashes (75%), followed by falls (12%) and violent assaults (8%). There were 150 (51%) mandibular, 102 (34%) maxillary, and 22 (7.4%) zygomatic fractures. Regarding distribution of mandibular fractures, the majority (25%, 38/150) occurred in the condyle, 23% (35/150) in the angle, and 20% (30/150) in the body. The distribution of maxillary fractures were 49.0% (50/102) dentoalveolar, 29.4% (30/102) Le Fort I, and 10.7% (11/102) were Le Fort II fractures. More than half of all cases were treated by closed reduction (67%). Complications occurred in 5.6% of patients. Conclusion The findings of this study, compared with similar studies reported in the literature, support the view that the causes and incidence of maxillofacial injuries vary from one country to another and, as such, can provide a guide to the design of programs geared toward prevention and treatment.

319 citations

Journal ArticleDOI
Lydia M. Haile1, Kaloyan Kamenov2, Paul S Briant3, Aislyn U. Orji4  +227 moreInstitutions (26)
TL;DR: In this paper, the authors present updated estimates from the Global Burden of Disease (GBD) study on the prevalence of hearing loss in 2019, as well as the condition's associated disability.

253 citations

Journal ArticleDOI
TL;DR: The literature on Six Sigma from 417 referred journal articles from 1992 to 2008 were systematically analyzed based on a scheme that consists of four distinct dimensions: publication year and journal, major themes, research type, and application sector as mentioned in this paper.
Abstract: Purpose – This paper aims to clarify emerging aspects and trends of Six Sigma literature over 17 years, from 1992 to 2008Design/methodology/approach – The literature on Six Sigma from 417 referred journal articles in business and management disciplines, information systems and computer science, engineering, healthcare, etc were systematically analyzed based on a scheme that consists of four distinct dimensions: publication year and journal, major themes, research type, and application sector (ie manufacturing vs service)Findings – A number of key findings emerged: Six Sigma research is growing rapidly, covering various disciplines and domains with a great focus on Six Sigma tools and techniques; empirical research is dominant with more emphasis on case study approach; and the growing gap between manufacturing‐ and service‐focused articles implies the return of Six Sigma to manufacturing as its initial base Although a large volume of literature is available on Six Sigma, the topic is still under deve

241 citations

Journal ArticleDOI
TL;DR: The paper provides procurement system developers and managers with a useful adoption model that demonstrates the significance of perceived usefulness of e‐procurement system in influencing the adoption decision, as well as understanding the importance of both technology‐related aspects and social influence in e‐ procurement adoption.
Abstract: – The purpose of this paper is to predict e‐procurement adoption through integrating the constructs of the technology acceptance model and the theory of planned behaviour., – A structural equation modelling is conducted through the analysis of 316 usable questionnaires., – The results show that the proposed model has good explanatory power and confirms its robustness, with a reasonably strong empirical support, in predicting users' intentions to use e‐procurement technology. Behavioural intention toward e‐procurement technology is mainly determined by user's attitude and additionally influenced by perceived usefulness and subjective norm., – The paper provides procurement system developers and managers with a useful adoption model that demonstrates the significance of perceived usefulness of e‐procurement system in influencing the adoption decision. This highlights the importance of maximizing the benefits of e‐procurement system for potential users to facilitate the adoption process., – System developers and procurement managers should also consider the role of social influences, such as these from supply chain partners, in the adoption process and how such influences may facilitate or inhibit e‐procurement adoption process., – The paper is the first study that examines e‐procurement adoption in the United Arab Emirates. Also, the findings allow us to understand the importance of both technology‐related aspects and social influence in e‐procurement adoption.

222 citations


Authors

Showing all 756 results

NameH-indexPapersCitations
Muhammad Imran94305351728
Shaher Momani6430113680
Sunil Kumar441805294
Mohamed Abd Elaziz351893959
Amit K. Tiwari331464422
Mohammed Azmi Al-Betar311624095
Mohammed Al-Smadi31982902
Praveen Agarwal303073345
Amine Bahi28532011
Mohamed Deriche272553324
Hany A. Omar271051948
Sai H.S. Boddu24882367
Subish Palaian241501533
Adel Ouannas241281753
Mohammed A. Awadallah23711889
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202311
202237
2021401
2020270
2019158
201879